Patents by Inventor Takeshi Tabira

Takeshi Tabira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant adeno-associated virus vector for treatment of Alzheimer disease
    Patent number: 8318687
    Abstract: Disclosed is an adeno-associated virus vector capable of expressing a peptide fragment containing a humoral immunity induction site of the ?-amyloid peptide, comprising DNA encoding the peptide fragment in an operative form.
    Type: Grant
    Filed: June 11, 2004
    Date of Patent: November 27, 2012
    Inventors: Takeshi Tabira, Hideo Hara
  • Highly safe intranasally administrable gene vaccines for treating alzheimer's disease
    Publication number: 20090170798
    Abstract: An objective of the present invention is to provide a safe and effective vaccine therapy for Alzheimer's disease. A minus strand RNA viral vector carrying amyloid gene was constructed, and administered intranasally to 24- to 25-months-old APP transgenic mice. The level of serum anti-A 42 antibody was determined and showed to be markedly higher than the control. The results of histological investigation showed that the administration of a vector of the present invention markedly reduced senile plaques in all of the frontal lobe, parietal lobe, and hippocampus. The brain A level was also markedly reduced. Furthermore, the administration of a vector of the present invention did not result in lymphocyte infiltration in the central nervous system.
    Type: Application
    Filed: April 20, 2006
    Publication date: July 2, 2009
    Applicants: JAPAN AS REPRESENTED BY PRESIDENT OF NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY, DNAVEC CORPORATION
    Inventors: Hideo Hara, Takeshi Tabira, Yoshikazu Yonemitsu, Makoto Inoue, Yumiko Tokusumi, Mamoru Hasegawa
  • Recombinant Adeno-Associated Virus Vector for Treatment of Alzheimer Disease
    Publication number: 20090004144
    Abstract: Disclosed is an adeno-associated virus vector capable of expressing a peptide fragment containing a humoral immunity induction site of the ?-amyloid peptide, comprising DNA encoding the peptide fragment in an operative form.
    Type: Application
    Filed: June 11, 2004
    Publication date: January 1, 2009
    Applicants: Japan as Represented by President of Natinal Center of Geriatrics and Gerontology, National Institute of Biomedical Innovation
    Inventors: Takeshi Tabira, Hideo Hara