Abstract: A probe card including an insulating layer, a first conductor at least partially extending along a surface of the insulating layer, and a second conductor at least partially penetrating at least a portion of the insulating layer.

Abstract: An exchangeable contact unit which can be attached to or detached from a main body of an inspection jig, includes: a flexible board which is provided with a contact part with respect to an object to be inspected; and a coaxial connector which is directly and electrically connected to the flexible board.

Abstract: A block has a planar portion abutting a back side of a contact region of a flexible substrate, and a recess that is concave with respect to the planar portion. An electronic component mounted on the flexible substrate is located within the recess. When viewed from a direction perpendicular to the planar portion, the recess is located at a position near a power supply bump, except at a position overlapping the power supply bump, or the recess is filled with a filler. The planar portion of the block abuts only the back side of the power supply bump.

Abstract: A block has a planar portion abutting a back side of a contact region of a flexible substrate, and a recess that is concave with respect to the planar portion. An electronic component mounted on the flexible substrate is located within the recess. When viewed from a direction perpendicular to the planar portion, the recess is located at a position near a power supply bump, except at a position overlapping the power supply bump, or the recess is filled with a filler. The planar portion of the block abuts only the back side of the power supply bump.

Abstract: An exchangeable contact unit which can be attached to or detached from a main body of an inspection jig, includes: a flexible board which is provided with a contact part with respect to an object to be inspected; and a coaxial connector which is directly and electrically connected to the flexible board.

Abstract: A contact probe includes: a first and second plungers, one of the first and second plungers being connected to an object to be inspected, the other being connected to an inspecting board; and a spring urging the first and second plungers so as to be separated from each other. The first plunger includes a distal end side columnar part and a flange part. The flange part includes a first portion that has a first length from a center point, which is, greater than a radius of the distal end side columnar part, in a first direction perpendicular to an axial direction, and includes a second portion that has a second length from the center point, which is smaller than the radius of the distal end side columnar part, in a second direction perpendicular to the axial direction and different from the first direction.

Abstract: A contact probe includes: a first and second plungers, one of the first and second plungers being connected to an object to be inspected, the other being connected to an inspecting board; and a spring urging the first and second plungers so as to be separated from each other. The first plunger includes a distal end side columnar part and a flange part. The flange part includes a first portion that has a first length from a center point, which is, greater than a radius of the distal end side columnar part, in a first direction perpendicular to an axial direction, and includes a second portion that has a second length from the center point, which is smaller than the radius of the distal end side columnar part, in a second direction perpendicular to the axial direction and different from the first direction.

Abstract: An inspection unit includes: a metal block having a through hole; a contact probe for grounding which is coaxially arranged in through hole; and a coil spring having electrical conductivity at least on a surface thereof and provided between an inner peripheral face of the through hole and an outer peripheral face of the contact probe. The coil spring includes: a first coil part a part of which is in contact with the inner peripheral face of the through hole; and a second coil part a part of which is in contact with the outer peripheral face of the contact probe.

Abstract: An inspection unit includes: a metal block having a through hole; a contact probe for grounding which is coaxially arranged in through hole; and a coil spring having electrical conductivity at least on a surface thereof and provided between an inner peripheral face of the through hole and an outer peripheral face of the contact probe. The coil spring includes: a first coil part a part of which is in contact with the inner peripheral face of the through hole; and a second coil part a part of which is in contact with the outer peripheral face of the contact probe.

Abstract: A process for an induction culture of a cytotoxic T lymphocyte having cell killing activities against a tumor cell which comprises the step of coculturing a tumor tissue containing said tumor cell and a lymphocyte of autologous peripheral blood obtained from a subject from which the tumor tissue is derived. The process is convenient since no separation and pure culture of tumor cells is required. The resulting cytotoxic T lymphocyte cells are useful for clinical treatments of tumors, e.g. adoptive immunotherapies.

Abstract: Methotrexate, which is a known anticancer agent, can be converted into a polymeric conjugate with a pyran copolymer, which in itself has a certain anticancer effect, by a method in which an alkylene diamine is reacted with the carboxyl group of the methotrexate molecule to give an amidation product having a free amino group in a molecule, which is then reacted with the carboxyl group of the pyran copolymer, of which at least 10% of the repeating units have been modified with the methotrexate residue. The polymeric conjugate has sustained releasability of the methotrexate compound in blood serum so that an excellent therapeutic effect can be obtained by the administration thereof against cancers with little problems due to the side effects caused by an unduly high concentration of the drug in blood unavoidable when methotrexate as such is administrated.

Abstract: A macromolecular mitomycin derivative excellent in antitumor ability is produced by causing a specific divinyl ether-maleic anhydride copolymer to react with a specific aminocarboxylic acid and causing mitomycin C to react on the resultant reaction product. The derivative is optionally converted into a pharmacologically acceptable salt.