Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: [Problem] Provided is a multispecific antibody for preventing or treating amyotrophic diseases such as inclusion body myositis by binding to ActRIIA, ActRIIB, and Fn14, and inhibiting an amyotrophic action which occurs via ActRIIA, ActRIIB, and Fn14. [Means for Solution] The present inventors have conducted studies on a multispecific antibody, and provided a multispecific antibody including a polypeptide consisting of the amino acid sequence of SEQ ID NO: 2 and a polypeptide consisting of the amino acid sequence of SEQ ID NO: 4.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: An objective of the present invention is to provide an anti-TSPAN8/anti-CD3 bispecific antibody and an anti-TSPAN8 antibody usable in treatment or prevention in human. A human monoclonal antibody producing mouse was immunized with a peritoneal disseminated cancer cell isolated from a patient, to obtain an antibody 16B11 and an antibody 16B12 that selectively bind to a peritoneal disseminated cancer cell. These antibodies were anti-TSPAN8 antibodies that bind to the region from amino acid positions 126 to 155 of TSPAN8 and exhibited strong binding activity to TSPAN8 expressed in the peritoneal disseminated cancer cell. Further, an anti-TSPAN8(16B11)-anti-CD3 bispecific antibody produced based on the sequence of 16B11 exhibited a cytotoxic activity against the TSPAN8-expressing cancer cell in vitro, exerted an anti-tumor action on TSPAN8-expressing cancer cell-bearing mice in vivo, and extended the lifetime of peritoneal dissemination model mice.

Abstract: An image generation device and an appearance inspection device which can increase the number of types of training image are provided. An image generation device includes an image acquisition unit configured to acquire a first image; and an image generator configured to generate a training image based on the first image, wherein the first image depicts a first defect included in a first product of a different type the product to be inspected, and the training image is a image to be read by an identifier that identifies whether an inspection image obtained by imaging the product to be inspected depicts a same type of defect as the first defect and to be used by the identifier to perform learning.

Abstract: An image generation device and an appearance inspection device which can increase the number of types of training image are provided. An image generation device includes an image acquisition unit configured to acquire a first image; and an image generator configured to generate a training image based on the first image, wherein the first image depicts a first defect included in a first product of a different type the product to be inspected, and the training image is a image to be read by an identifier that identifies whether an inspection image obtained by imaging the product to be inspected depicts a same type of defect as the first defect and to be used by the identifier to perform learning.

Abstract: A method of managing reuse of a returnable bottle is disclosed. The method individually manages returnable bottles so as to manage reuse linked with their individual states of use and thereby enable reusable bottles to be separated from other bottles in a scientific manner. The method comprises, at the time of new production of a returnable bottle body, forming on a bottle body surface a product identification mark part engraved with an identification code as product identification data of the bottle body, reading the product identification mark part and writing and storing the product identification data of the bottle body in the storage medium linked with individual transport state data relating to transport of the bottle body, and judging permission for continued reuse of the bottle body based on the individual transport state data stored in the storage medium.

Abstract: A method of managing reuse of a returnable bottle is disclosed. The method individually manages returnable bottles so as to manage reuse linked with their individual states of use and thereby enable reusable bottles to be separated from other bottles in a scientific manner. The method comprises, at the time of new production of a returnable bottle body, forming on a bottle body surface a product identification mark part engraved with an identification code as product identification data of the bottle body, reading the product identification mark part and writing and storing the product, identification data of the bottle body in the storage medium linked with individual transport state data relating to transport of the bottle body, and judging permission for continued reuse of the bottle body based on the individual transport state data stored in the storage medium.

Abstract: A novel method of managing reuse of a returnable bottle which individually manages returnable bottles so as to manage reuse linked with their individual states of use and thereby enable reusable bottles to be accurately, easily, and efficiently separated from other bottles in a scientific manner and enable efficient inspection of aging and other factors which cannot be determined from outside appearance, also, a method of managing reuse of a returnable bottle efficiently promoting reuse of returnable bottles and thereby lowering the costs relating to reuse and reducing energy and otherwise benefitting the environment, comprising, at the time of new production of a returnable bottle body, forming on a bottle body surface a product identification mark part engraved with an identification code as product identification data of the bottle body, reading the product identification mark part and writing and storing the product identification data of the bottle body in the storage medium linked with individual usage

Abstract: The present invention relates to a plasmon generator, in which a surface plasmon is excited by application of light. The plasmon generator extends along one direction. The plasmon generator includes a first end surface that is positioned on one end in the one direction and at which near-field light is generated along with the excitation of the plasmon; and a second cross section that is substantially parallel to the first end surface and is away from the first end surface. The first end surface has a polygonal shape that does not have a substantially acute inner angle. The second cross section has an upper part that has a shape substantially the same as or similar to that of the first end surface and a flare shaped lower part that is connected to the upper part and has a width that increases as it is far from the upper part.

Abstract: A thermally assisted magnetic write head includes a waveguide having a first end surface included in an air bearing surface; a magnetic pole having a second end surface included in the air bearing surface; a plasmon generator having a third end surface included in the air bearing surface; a first protective film directly covering a part of the second end surface of the magnetic pole at least; and a second protective film directly covering the first end surface of the waveguide and the third end surface of the plasmon generator. The configuration can reduce recording density and improve thermal stability, furthermore increase the producing yield.

Abstract: The present invention relates to a plasmon generator, in which a surface plasmon is excited by application of light. The plasmon generator extends along one direction. The plasmon generator includes a first end surface that is positioned on one end in the one direction and at which near-field light is generated along with the excitation of the plasmon; and a second cross section that is substantially parallel to the first end surface and is away from the first end surface. The first end surface has a polygonal shape that does not have a substantially acute inner angle. The second cross section has an upper part that has a shape substantially the same as or similar to that of the first end surface and a flare shaped lower part that is connected to the upper part and has a width that increases as it is far from the upper part.

Abstract: A plasmon generator of a thermally-assisted magnetic recording head has a first configuration member having a near-field light generation end surface at an ABS, and a second configuration member being in contact with main magnetic pole, and terminating at a front end portion of a slope positioned at the position recessed from the ABS. An end part of a separator layer, which is interposed between the main magnetic pole and the first configuration member, on a side opposite to the ABS is at a position more recessed from the air bearing surface than the front end portion of the slope of the second configuration member.

Abstract: A plasmon generator of a thermally-assisted magnetic recording head has a first configuration member having a near-field light generation end surface at an ABS, and a second configuration member being in contact with main magnetic pole, and terminating at a front end portion of a slope positioned at the position recessed from the ABS. An end part of a separator layer, which is interposed between the main magnetic pole and the first configuration member, on a side opposite to the ABS is at a position more recessed from the air bearing surface than the front end portion of the slope of the second configuration member.

Abstract: An improved pour spout member having a base attached to a packaging bag, a tubular neck having a tip opening sealed by a sealing member, and a lid member having an upper end connected to the sealing member and covering an outer periphery of the tubular neck. The lid member includes expandable lid segments having upper ends connected to a portion integral with the sealing member and, between the expandable lid segments in a collapsed state and a portion integral with the tubular neck, there is provided a rotation locking mechanism enabling temporary restriction of the lid member.

Abstract: A thermally-assisted magnetic recording head includes a medium facing surface, a magnetic pole, a waveguide including a core and a cladding, and a plasmon generator. The magnetic pole is located forward of the core in the direction of travel of a magnetic recording medium. The plasmon generator is disposed between the core and the magnetic pole. The core has an evanescent light generating surface facing toward the plasmon generator. The plasmon generator has a front end face located in the medium facing surface, a flat surface facing toward the'evanescent light generating surface, and first and second side surfaces that are at a distance from each other and are located farther from the evanescent light generating surface than is the flat surface.

Abstract: A heat-assisted magnetic write head includes a magnetic pole having an end surface exposed at an air bearing surface, a waveguide extending toward the air bearing surface to propagate light, and a plasmon generator provided between the magnetic pole and the waveguide, and generating near-field light from the air bearing surface, based on the light propagated through the waveguide. The plasmon generator has an end portion exposed at the air bearing surface or located in close proximity to the air bearing surface, the end portion having a minimum thickness in a region close to the waveguide.

Abstract: A thermally-assisted magnetic recording head includes: a medium facing surface; a magnetic pole; a waveguide including a core and a cladding; a plasmon generator; and a protruding member. The protruding member is disposed between the medium facing surface and a front end face of the core facing toward the medium facing surface. The protruding member has a first end face located in the medium facing surface, and a second end face facing toward the front end face of the core and receiving light having propagated through the core and passed through the front end face. The protruding member is formed of a metal different from both a material forming the magnetic pole and a material forming the plasmon generator. The protruding member is heated and expanded by the light received at the second end face, so that the first end face gets protruded toward a magnetic recording medium.

Abstract: A heat-assisted magnetic write head includes a magnetic pole having an end surface exposed at an air bearing surface, a waveguide extending toward the air bearing surface to propagate light, and a plasmon generator provided between the magnetic pole and the waveguide, and generating near-field light from the air bearing surface, based on the light propagated through the waveguide. The plasmon generator has an end portion exposed at the air bearing surface or located in close proximity to the air bearing surface, the end portion having a minimum thickness in a region close to the waveguide.

Abstract: The present invention provides novel target proteins and target genes for drug discovery, and the means that enable the development of novel drugs using the same. More particularly, the present invention provides NCS proteins and genes thereof; screening methods for drug (for example, anti-central nervous disease drug); agents for regulating disease (for example, central nervous disease); production methods of a drug derivative; a complex comprising a drug and NCS protein, and a method of producing the complex; a kits comprising a drug or a salt thereof; determination methods for the onset or risk of onset of a specified disease, determination methods for susceptibility to a drug, and determination kits used for the determination methods; and the like.