Abstract: A method of making a bottle with a handle, wherein a synthetic-resin parison is disposed in half-cylindrical molds with a handle body, which is blow-molded and at the same time integrated with the handle body, characterized in that the parison is disposed between the opened molds; the handle body is tacked to a face of matching faces of the half-cylindrical molds; the molds are closed; and the blow-molding is performed.

Abstract: Disclosed is a novel physiologically active substance, MH435, represented by the formula: ##STR1## wherein R represents either of the following groups A and B A: --CH.dbd.CH--NHCHOB: --CH.sub.2 --CH.sub.2 --NHCHO.The substance MH435 has an inhibitory activity against tyrosine specific protein kinase, and the 50% inhibitory concentrations of the substances MH435-A and MH435-B are respectively 0.55 .mu.g/ml and 6.0 .mu.g/ml.

Abstract: An anthracycline, serirubicin, of the formula: ##STR1## wherein R represents the substituent: ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, serirubicin, and then recovering the anthracycline compound, serirubicin, from the cultured medium. This serirubicin, or an acid addition salt of the serirubicin, can be contained as the active ingredient in anti-tumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

Abstract: An anthracycline compound, ditrisarubicin, of the formula: ##STR1## wherein R represents one of the following substituents (A), (B), and (C): ##STR2## is produced by a process which comprises cultivating a strain of Streptomyces in a suitable culture medium under aerobic conditions, said strain having the ability to produce the anthracycline compound, ditrisarubicin, and then recovering the anthracycline compound, ditrisarubicin, from the cultured medium. This ditrisarubicin, or an acid addition salt of the ditrisarubicin, can be contained as the active ingredient in antitumor agents and in pharmaceutical compositions for treatment of infections induced by gram-positive microorganisms, whereby good results are attainable.

Abstract: A metal-reinforced synthetic wood material which is composted of a metal assembly used for reinforcement, and synthetic resin for covering the metal assembly. The metal assembly is, for example, formed of a high-carbon special steel, and the synthetic resin is, for example, foamed polyurethane. This synthetic wood material is manufactured by a method, which method includes the steps of placing the metal assembly in a mold of a molding machine, and injecting the resin material into the mold in a reaction injection molding. Thus, the synthetic wood material having high moisture resistance and sufficient strength can be obtained.