Abstract: A metallic image forming method is a method for forming a metallic image with a metallic ink containing an organic coloring agent capable of exhibiting a metallic color on a recording medium provided with an undercoat layer thereon having a black color or an opposite color to the color of diffused light from the metallic ink. The method includes applying the metallic ink onto the recording medium so as to cover at least part of the undercoat layer.

Abstract: Provided is a metallic image forming method by which a metallic image that assumes sufficient metallic feeling can be acquired. The metallic image forming method is a method of forming a metallic image on a recording medium through use of an ink containing metal particles and includes an ink application step of applying an ink onto a recording medium having an underlayer formed thereon such that the ink overlaps at least a part of the underlayer, the underlayer having a black color or an opposite color with respect to diffusion light of the ink.

Abstract: Provided is a metallic image forming method by which a metallic image that assumes sufficient metallic feeling can be acquired. The metallic image forming method is a method of forming a metallic image on a recording medium through use of an ink containing metal particles and includes an ink application step of applying an ink onto a recording medium having an underlayer formed thereon such that the ink overlaps at least a part of the underlayer, the underlayer having a black color or an opposite color with respect to diffusion light of the ink.

Abstract: Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).

Abstract: An aqueous ink for inkjet use contains particles of a compound represented by general formula (I) below and a dispersant that disperses the particles: wherein R1 represents an aromatic ring; R2 represents a hydrogen atom, an alkyl group, or a benzene ring; when R2 is a hydrogen atom or an alkyl group, n is 1; and when R2 is a benzene ring, n is an integer of any one of 1 to 3.

Abstract: A metallic image forming method is a method for forming a metallic image with a metallic ink containing an organic coloring agent capable of exhibiting a metallic color on a recording medium provided with an undercoat layer thereon having a black color or an opposite color to the color of diffused light from the metallic ink. The method includes applying the metallic ink onto the recording medium so as to cover at least part of the undercoat layer.

Abstract: An aqueous ink for inkjetting, capable of recording an image exhibiting a natural metallic color with reduced diffused light having a color hue different from the desired metallic color by an inkjetting method, is provided. The aqueous ink for inkjetting includes organic colorant particles made of an organic colorant giving a metallic color, and a black color dye. Alternatively the aqueous ink for inkjetting includes metal particles giving a metallic color on a recording medium, and a black color dye.

Abstract: An ink jet aqueous ink including particles of a compound represented by the following general formula (I); a dispersant for dispersing the particles; and water, where, in the general formula (I), R1 and R2 each independently represent an alkyl group, R3 represents an alkyl group or an aryl group, R4 represents an alkyl group, and X represents an alkyl group or a group represented by NR5R6, where R5 and R6 each independently represent a hydrogen atom, an alkyl group, or an acyl group.

Abstract: Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).

Abstract: Aspects of the present invention provide an ink-jet recording method including the step of applying an ink to a recording medium by discharging the ink from a recording head by action of thermal energy and the step of fixing the ink to the recording medium by heating the ink applied to the recording medium. The ink contains water, a self-dispersing pigment, and resin particles. The resin particles have a glass transition temperature of not less than 25° C., an average particle diameter of 70 nm or more and 220 nm or less, and an acid value of 25 mg KOH/g or more and 150 mg KOH/g or less.

Abstract: An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. This problem can be solved with a pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by formula [I] below which has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

Abstract: The invention provides an ink jet recording ink containing a self-dispersion pigment to a surface of which an anionic functional group represented by the following general formula (1) is bonded directly or through another atomic group, an ammonium salt of an organic carboxylic acid, water, and a water-soluble compound having a hydrophilicity-hydrophobicity coefficient of 0.26 or more as defined by the following equation (A), the ink having a surface tension of 34 mN/m or less, wherein M1 and M2 are, independently of each other, a hydrogen atom, alkali metal, ammonium or organic ammonium; Hydrophilicity-hydrophobicity coefficient=[(Water activity of a 20% aqueous solution)?(Molar fraction of water in the 20% aqueous solution)]/[1?(Molar fraction of water in the 20% aqueous solution)]??(A).

Abstract: An inkjet recording ink having a surface tension of 34 mN/m or more is provided. The inkjet recording ink contains an anionic self-dispersion pigment having an anionic functional group, a salt, and a water-soluble compound having a hydrophilicity/hydrophobicity coefficient of 0.26 or more. The ink contains a larger amount of cesium ion than the amount of the anionic functional group. The hydrophilicity/hydrophobicity coefficient is defined by equation (A).

Abstract: Aspects of the present invention provide an ink-jet recording method including the step of applying an ink to a recording medium by discharging the ink from a recording head by action of thermal energy and the step of fixing the ink to the recording medium by heating the ink applied to the recording medium. The ink contains water, a self-dispersing pigment, and resin particles. The resin particles have a glass transition temperature of not less than 25° C., an average particle diameter of 70 nm or more and 220 nm or less, and an acid value of 25 mg KOH/g or more and 150 mg KOH/g or less.

Abstract: The present invention relates to an aqueous ink having a surface tension of 34 mN/m or less including a self-dispersion pigment and water. In the aqueous ink, the self-dispersion pigment has a plurality of pKa values that are 8.0 or less. Assuming that the lowest pKa value among the plurality of pKa values is pKa1 and the highest pKa value among the plurality of pKa values is pKa2, pKa1 and pKa2 satisfy Mathematical formula (1), and the pH value of the aqueous ink satisfies Mathematical formula (2).

Abstract: An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastral diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alpecia, irritable bowel syndrome, sleep disorders, dermatitides, schizophrenia, pain, etc. A pyrrolopyrimidine or pyrrolotriazine derivative substituted with a carbamoyl group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

Abstract: Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for mode disorder such as depression, anxiety disorder, anorexia, cachexia, pain and drug dependence, whose action relies on the MC4 receptor antagonistic effect.

Abstract: Provided is a novel probe for a biological specimen for labelling by itself and clearly visualizing one of a specific cell and a specific cell organ in a living body, the probe having excellent spectral characteristics and exhibiting excellent storage stability. The probe for a biological specimen contains, as an active agent, at least one kind of compound represented by a general formula (I).

Abstract: It is intended to provide a drug which is efficacious against pathological conditions relating to arginine-vasopressin V1b receptor. More particularly speaking, it is intended to provide a drug which has a therapeutic or preventive effect on depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, hypertension, digestive diseases, drug addiction, epilepsy, brain infarction, brain ischemia, brain edema, head injury, inflammation, immune diseases, alopecia and so on. As the results of intensive studies, a novel 1,3-dihydro-2H-indol-2-one compound and a pyrrolidin-2-one compound fused with a heteroaromatic ring, which are highly selective antagonists of arginine-vasopressin V1b receptor, have high metabolic stabilities and show favorable brain penetration and high plasma concentrations, are found, thereby achieving the above objective.

Abstract: An ink jet image forming method, wherein an ink is applied to plain paper in a fixed amount of 0.5 to 6.0 pl, contains a self-dispersion pigment, an organic carboxylic acid salt, water and a water-soluble compound having a hydrophilicity-hydrophobicity coefficient of 0.26 or more, and has a surface tension of 34 mN/m or less, and when the total amount of inks applied to a fundamental matrix for forming an image is 5.0 pl/cm2 or less, and the duty of an ink of a color applied to the fundamental matrix is 80% duty or more, the application of the ink of a color to the fundamental matrix is conducted within a range of 1 to 200 msec and at plural timings within the above range, and the amount of the ink of a color applied at each timing is controlled to 0.7 pl/cm2 or less.