Patents by Inventor Takeuchi Toshihilo

Takeuchi Toshihilo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening
    Patent number: 8716195
    Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: May 6, 2014
    Assignee: Bioren, Inc.
    Inventors: Guido Cappuccilli, Roberto Crea, Takeuchi Toshihilo, Randy Shen, Ramesh R. Bhatt, Nurten Beyaz-Kavuncu
  • Antibody Ultrahumanization by Predicted Mature CDR Blasting and Cohort Library Generation and Screening
    Publication number: 20090318297
    Abstract: Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
    Type: Application
    Filed: November 10, 2006
    Publication date: December 24, 2009
    Applicant: Pfizer, Inc.
    Inventors: Guido Cappucilli, Roberto Crea, Takeuchi Toshihilo, Randy Shen, Rarnesh Bhatt, Nurten Beyaz-Kavuncu