Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: Compositions and methods for treating and/or ameliorating obesity are provided. In certain embodiments, the compositions comprise the topical vitamin D3 derivative MC903. In other embodiments, the compositions systemically increase TSLP levels in a subject. In yet other embodiments, the compositions include TSLP peptide isoforms and/or adeno-associated viral vectors containing TSLP-expressing sequences. Methods using these compositions increase TSLP levels in the subject and cause selective loss of white adipose tissue without loss in muscle mass.

Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: In a hybrid vehicle, a power control unit configured to control an engine and a motor, and a vaporized gas control valve are disposed in an engine compartment located in a front portion of the vehicle. The vaporized gas control valve is disposed on a purge pipe that introduces fuel-vaporized gas generated in a fuel tank into the engine, to adjust flow of the fuel-vaporized gas. The power control unit is stored within a casing, and the vaporized gas control valve is disposed on a top portion of a side wall of the casing.

Abstract: In a hybrid vehicle, a power control unit configured to control an engine and a motor, and a vaporized gas control valve are disposed in an engine compartment located in a front portion of the vehicle. The vaporized gas control valve is disposed on a purge pipe that introduces fuel-vaporized gas generated in a fuel tank into the engine, to adjust flow of the fuel-vaporized gas. The power control unit is stored within a casing, and the vaporized gas control valve is disposed on a top portion of a side wall of the casing.

Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: Compositions and methods are provided for the treatment and/or prevention of an inflammatory and/or autoimmune disease or disorder.

Abstract: Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.

Abstract: The present invention includes a method of suppressing systemic immune response in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof. The present invention further includes a method of treating an autoimmune disease in a subject, the method comprising topically administering a pharmaceutically effective amount of a vitamin D analog to a subject in need thereof.

Abstract: Compositions and methods for treating a cytokine release syndrome such as chimeric antigen receptor T-cell cytokine release syndrome or hemophagocytic lymphohistiocytosis are provided.

Abstract: Compositions and methods are provided for the treatment and/or prevention of an inflammatory and/or autoimmune disease or disorder.

Abstract: A vehicle front structure includes: a motor unit for driving front wheels that is accommodated in a motor room formed in a front portion of a vehicle, and that has a driving shaft arranged coaxially with drive shafts connected to the front wheels; an air compressor that is securely attached to a rear portion of the motor unit in a vehicle longitudinal direction; a front side member that is arranged outward of the motor unit in a vehicle lateral direction, and that extends in the vehicle longitudinal direction; a cross member that is arranged above the motor unit in a vehicle height direction, that extends in the vehicle lateral direction, and that is connected to the front side member; and an inverter that is arranged above the cross member in the vehicle height direction, and that supplies electric power to the motor unit.

Abstract: A vehicle front structure includes: a motor unit for driving front wheels that is accommodated in a motor room formed in a front portion of a vehicle, and that has a driving shaft arranged coaxially with drive shafts connected to the front wheels; an air compressor that is securely attached to a rear portion of the motor unit in a vehicle longitudinal direction; a front side member that is arranged outward of the motor unit in a vehicle lateral direction, and that extends in the vehicle longitudinal direction; a cross member that is arranged above the motor unit in a vehicle height direction, that extends in the vehicle lateral direction, and that is connected to the front side member; and an inverter that is arranged above the cross member in the vehicle height direction, and that supplies electric power to the motor unit.

Abstract: A vehicular torque rod includes: a torque rod main body that has one end portion and the other end portion in a longitudinal direction of the torque rod main body, the one end portion being joined to a power unit, the other end portion being joined to a body-side joint portion, the torque rod main body coupling and supporting the power unit with the body-side joint portion; and a weight member disposed on an intermediate portion of the torque rod main body in the longitudinal direction.