Patents by Inventor Taku Nagao
Taku Nagao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5134139Abstract: Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein X is hydrogen atom, a halogen atom or a lower alkyl group; R.sup.1 is a lower alkyl group or a lower alkoxy group; R.sup.2 is hydrogen atom, a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenyl-lower alkyl grup or a diphenyl-lower alkyl group; R.sup.3 is a lower alkyl group or a substituted or unsubstituted phenyl-lower alkyl group, Q is single bond, or an alkylene or lower alkenylene group which may optionally be substituted by a lower alkoxy group or oxo group; R.sup.Type: GrantFiled: August 21, 1990Date of Patent: July 28, 1992Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Akiyoshi Kawai, Hirozumi Inoue, Hiroshi Narita, Taku Nagao
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Patent number: 4822789Abstract: Disclosed is a method for producing a renal function-improving and diuretic effects on a warm-blooded animal which comprises administering to the warm-blooded animal a therapeutically effective amount of 2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-8-chloro-2,3-dihy dro-1,5-benzothiazepin-4(5H)-one or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: February 1, 1988Date of Patent: April 18, 1989Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Isao Yamaguchi, Yoshiaki Akimoto, Taku Nagao
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Patent number: 4778791Abstract: Disclosed are a pharmaceutical composition for improving the constitution of lipids in blood, which comprises as an active ingredient 2-(4-methoxyphenyl)-3-acetoxy-5-[2-(dimethylamino)ethyl]-8-chloro-2,3-dihy dro-1,5-benzothiazepin-4(5H)-one or a pharmaceutically acceptable acid addition salt thereof, use of the compound for preparing the pharmaceutical composition and a method of improving the constitution of lipids in blood.Type: GrantFiled: May 5, 1987Date of Patent: October 18, 1988Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Kohki Takashima, Tetsuji Mori, Taku Nagao
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Patent number: 4777178Abstract: A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen or a lower alkyl group, R.sup.3 is hydrogen, a lower alkyl group or a lower alkanoyl group, Q is a single bond or a lower alkylene group, Alk is a lower alkylene group, Y and Z are the same or different and are oxygen atom or sulfur atom and the group of the formula: ##STR2## is either ##STR3## or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.Type: GrantFiled: June 5, 1986Date of Patent: October 11, 1988Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Hideo Nakai, Hiroshi Wada, Taku Nagao, Hideo Yabana
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Patent number: 4689327Abstract: A novel thiazolidine derivative of the formula: ##STR1## wherein R.sup.1 is a substituted or unsubstituted phenyl group, Q is a single bond, a lower alkylene group or a lower alkenylene group, R.sup.2 and R.sup.3 are the same or different and each is hydrogen atom, a lower alkyl group, a cycloalkyl group, a lower alkanoyl group, a lower alkoxycarbonyl group, a lower alkylsulfonyl group, a benzoyl group, a phenyl group or a di(lower alkyl)phosphoryl group, Alk is a lower alkylene group, and Y and Z are the same or different and each is oxygen atom or sulfur atom, or a pharmaceutically acceptable salt thereof, which is useful as a cardiotonic agent is disclosed together with processes for the preparation of the compound and a pharmaceutical composition containing said compound.Type: GrantFiled: June 24, 1985Date of Patent: August 25, 1987Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Hideo Nakai, Hiroshi Wada, Taku Nagao, Hideo Yabana
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Patent number: 4665068Abstract: Novel 1,5-benzothiazepine derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkanoyl and each of R.sup.2 and R.sup.3 is lower alkyl, and a pharmaceutically acceptable acid addition salt thereof are disclosed.Said derivative (I) and a salt thereof are useful as a hypotensive agent and/or a cerebral or coronary vasodilator.Type: GrantFiled: October 31, 1985Date of Patent: May 12, 1987Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mikio Takeda, Tokuro Oh-ishi, Hiromichi Nakajima, Taku Nagao
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Patent number: 4594342Abstract: Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.4 are:(a) R.sup.1 is lower alkyl or lower alkoxy, and R.sup.4 is lower alkyl, lower alkoxy, fluorine, benzyloxy, hydroxy or lower alkylthio, or(b) R.sup.1 is lower alkyl, and R.sup.4 is hydrogen, or(c) R.sup.1 is hydroxy, and R.sup.4 is lower alkyl, fluorine, hydroxy or lower alkylthio;R.sup.2 is hydrogen, lower alkanoyl or benzoyl; and R.sup.3 is lower alkyl; and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.Type: GrantFiled: March 22, 1985Date of Patent: June 10, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mikio Takeda, Tokuro Oh-ishi, Hiromichi Nakajima, Taku Nagao
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Patent number: 4590188Abstract: Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl or lower alkoxy, R.sup.2 is hydrogen atom or lower alkanoyl, each one of R.sup.3 and R.sup.4 is lower alkyl, Ring A is a substituted benzene ring of the formula: ##STR2## R.sup.a is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy, each one of R.sup.b and R.sup.c is lower alkyl, lower alkoxy or halogen atom, and either one of R.sup.d and R.sup.e is fluorine atom and the other one is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt are useful as a hypotensive agent and/or a cerebral or coronary vasodilator.Type: GrantFiled: February 4, 1985Date of Patent: May 20, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mikio Takeda, Tokuro Oh-ishi, Hiromichi Nakajima, Taku Nagao
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Patent number: 4585768Abstract: Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen, lower alkanoyl or benzyl, R.sup.3 is hydrogen or lower alkyl and either one of R.sup.4 and R.sup.5 is hydrogen and the other is chlorine, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.Type: GrantFiled: March 22, 1985Date of Patent: April 29, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mikio Takeda, Tokuro Oh-ishi, Hiromichi Nakajima, Taku Nagao
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Patent number: 4567175Abstract: Novel 8-chloro-1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen, lower alkyl or a group of the formula: R.sup.4 CO--, each of R.sup.2 and R.sup.3 is lower alkyl and R.sup.4 is hydrogen or lower alkyl, and a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and a pharmaceutically acceptable acid addition salt thereof are useful as hypotensive agents and/or coronary or cerebral vasodilators.Type: GrantFiled: May 16, 1984Date of Patent: January 28, 1986Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Mikio Takeda, Tokuro Oh-ishi, Hiromichi Nakajima, Taku Nagao
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Patent number: 4521430Abstract: A compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each lower alkyl, R.sup.3 is hydrogen, lower alkyl or hydroxy-lower alkyl, R.sup.4 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio or nitro, and A is lower alkylene, is disclosed. Said compound (I) and a pharmaceutically acceptable acid addition salt thereof are useful as cerebral or coronary vasodilators.Type: GrantFiled: May 25, 1984Date of Patent: June 4, 1985Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Tokuro Oh-ishi, Mikio Takeda, Hiromichi Nakajima, Taku Nagao
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Patent number: 4324800Abstract: A compound of the formula: ##STR1## wherein R is alkanoyl of one to 20 carbon atoms, benzoyl or lower alkyl-benzoyl, and processes for preparation thereof are disclosed. Said compound (I) and a pharmaceutically acceptable acid addition salt thereof are useful as a cardiotonic agent.Type: GrantFiled: March 12, 1981Date of Patent: April 13, 1982Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Norihide Umino, Tokuro Ohishi, Muneyoshi Ikezaki, Masanori Sato, Taku Nagao
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Patent number: 4131686Abstract: A compound of the formula: ##STR1## wherein R is lower alkyl, may be prepared, for example, by reducing a compound of the formula: ##STR2## wherein R is same as above. Other methods for preparing the compound [I] are also disclosed. The compound [I] and a pharmaceutically acceptable acid addition salt thereof are useful as anti-diabetic agents.Type: GrantFiled: December 6, 1976Date of Patent: December 26, 1978Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Yashushi Okazaki, Nobuo Ito, Masao Hoshiyama, Taku Nagao, Hiromichi Nakajima
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Patent number: 4072759Abstract: A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.Type: GrantFiled: November 10, 1976Date of Patent: February 7, 1978Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Nobuo Ito, Yasushi Okazaki, Masao Hoshiyama, Taku Nagao, Hiromichi Nakajima
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Patent number: 4032575Abstract: A compound having the formula: ##STR1## wherein Ring A is monohydroxyphenyl, or a pharmaceutically acceptable acid addition salt thereof is prepared by catalytic hydrogenation of a compound having the formula: ##STR2## wherein A' is monobenzyloxyphenyl, and Y is carbonyl or hydroxymethylene. The compound (I) in which Ring A is 4-hydroxyphenyl or 3-hydroxyphenyl is useful as a cardiotonic agent. On the other hand, the compound (I) in which Ring A is 2-hydroxyphenyl is useful as an anti-diabetic agent.Type: GrantFiled: October 1, 1975Date of Patent: June 28, 1977Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Nobuo Ito, Yasushi Okazaki, Masao Hoshiyama, Taku Nagao, Hiromichi Nakajima
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Patent number: 3952021Abstract: A compound of the formula: ##SPC1##Wherein Ring A' is dibenzyloxyphenyl and Y is carbonyl or hydroxymethylene, is subjected to catalytic hydrogenation. A compound of the formula: ##SPC2##Wherein Ring A is dihydroxyphenyl, is produced. The product is useful as a cardiotonic agent. It is also characterized by the high potency ratio of adrenergic .beta..sub.1 -receptor stimulating activity to adrenergic .beta..sub.2 -receptor stimulating activity.Type: GrantFiled: April 22, 1974Date of Patent: April 20, 1976Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Muneyoshi Ikezaki, Yasushi Okazaki, Nobuo Ito, Taku Nagao, Masao Hoshiyama, Hiromichi Nakajima