Abstract: An agent for inhibiting the action of a target RNA based on RNA interference and ASO with a passenger strand and a guide strand for a target RNA, wherein both ends of double-stranded RNA formed pairing of the passenger strand and the guide strand are blunt ends, and one or two or more selected from the group consisting of the units represented by formula (1) and formula (2) below at the following positions (a) and (b): (a) 5? end side and 3? end side of the passenger strand, (b) 3? end side of the guide strand (in which X represents an oxygen atom or sulfur atom), (in which X represents an oxygen atom or sulfur atom).

Abstract: A control device, when performing a reallocation control, makes the decrease gradient of regeneration braking force in a first period in which the amount of decrease in a basal fluid pressure from a reference basal fluid pressure is less than a specified amount of decrease greater than the decrease gradient of the regeneration braking force in a second period in which the amount of decrease in the basal fluid pressure is not less than the specified amount of decrease.

Abstract: A control signal output unit (a drive control unit) executes control to retain a gear position corresponding to a motor generator during deceleration of a vehicle and regeneration executed by the motor generator.

Abstract: The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.

Abstract: A control device, when performing a reallocation control, makes the decrease gradient of regeneration braking force in a first period in which the amount of decrease in a basal fluid pressure from a reference basal fluid pressure is less than a specified amount of decrease greater than the decrease gradient of the regeneration braking force in a second period in which the amount of decrease in the basal fluid pressure is not less than the specified amount of decrease.

Abstract: A control signal output unit (a drive control unit) executes control to retain a gear position corresponding to a motor generator during deceleration of a vehicle and regeneration executed by the motor generator.

Abstract: The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.

Abstract: An aluminum roof outer panel (2) is spot welded to a roof side rail (3) consisting of galvanized steel sheet. The outer panel (4) of the roof side rail is made of galvannealed steel sheet that has a favorable property but cannot be favorably welded to the aluminum roof outer panel, but the inner panel (5, 6) of the roof side rail is made of non-galvannealed steel sheet that can be favorably welded to the aluminum roof outer panel. Flanges of the outer panel (4) and inner panel (5, 6) overlap each other, and the flange of the outer panel is provided with a plurality of notches (11) along an edge of the outer panel. A corresponding flange of the roof outer panel is welded to the parts of the inner panel exposed by the notches of the outer panel.

Abstract: An aluminum roof outer panel (2) is spot welded to a roof side rail (3) consisting of galvanized steel sheet. The outer panel (4) of the roof side rail is made of galvannealed steel sheet that has a favorable property but cannot be favorably welded to the aluminum roof outer panel, but the inner panel (5, 6) of the roof side rail is made of non-galvannealed steel sheet that can be favorably welded to the aluminum roof outer panel. Flanges of the outer panel (4) and inner panel (5, 6) overlap each other, and the flange of the outer panel is provided with a plurality of notches (11) along an edge of the outer panel. A corresponding flange of the roof outer panel is welded to the parts of the inner panel exposed by the notches of the outer panel.

Abstract: The present invention provides a thermally crosslinking type curable composition having the following excellent performance and properties: it needs no poly vinyl chloride resin, and exhibits excellent adhesiveness even to aluminum alloy materials and the like. The curable composition is characterized in that a diluent and an adhesion promoter are compounded with a composition containing uncrosslinked type and/or partially crosslinked type synthetic rubber, a plasticizer, a filler and a core-shell type acrylic resin. As the diluent, there are preferably used paraffinic or naphthenic hydrocarbons obtained by distillation of crude oil, or chemically synthesized hydrocarbons which are the second or third class petroleum having a molecular weight of 200 or less.