Abstract: The purpose of the present invention is to provide a method for evaluating the clogging of a filtration membrane with a protein-containing solution, including the steps of: a) passing a protein-containing solution through a filtration membrane, b) after the step a), obtaining a filtration membrane cross-section from the filtration membrane, c) treating the protein-containing solution before the step a), the filtration membrane before the step b), or the filtration membrane cross-section after the step b) with at least one stain specific to a protein aggregate, and d) confirming the presence of the protein aggregate in the filtration membrane cross-section.

Abstract: A method for filtering a protein-containing liquid containing protein at a concentration of 20 mg/mL or more and 100 mg/mL or less, the method including a prefiltration step of filtering the protein-containing liquid by a prefilter having a pore size of 0.08 ?m to 0.25 ?m and including a hydrophobic resin, and a virus removal step of filtering the protein-containing liquid by a virus removal membrane including a synthetic polymer, after the prefiltration step, wherein the protein-containing liquid before conducting the prefiltration step includes 0.25 g or more of a trimer or higher multimer of the proteins having an average diameter of less than 100 nm, per 1 m2 of the virus removal membrane.

Abstract: An electron gun includes a cathode that is heated to emit thermions; a cathode heating power supply that supplies a cathode heating current for heating the cathode; a grid that has a first aperture formed therein and that has a grid voltage applied thereto, the grid voltage having a potential lower than that of the cathode, wherein the grid converges the thermions passing through the first aperture by the grid voltage; an anode that has a second aperture formed therein and that has an anode voltage applied thereto, wherein the anode causes the thermions extracted from the cathode to pass through the second aperture as an electron beam by the anode voltage; an anode-voltage power supply that applies the anode voltage to the anode; and a controller that causes the anode voltage having a positive potential to be applied from the anode-voltage power supply to the anode.

Abstract: An electron gun includes a cathode that is heated to emit thermions; a cathode heating power supply that supplies a cathode heating current for heating the cathode; a grid that has a first aperture formed therein and that has a grid voltage applied thereto, the grid voltage having a potential lower than that of the cathode, wherein the grid converges the thermions passing through the first aperture by the grid voltage; an anode that has a second aperture formed therein and that has an anode voltage applied thereto, wherein the anode causes the thermions extracted from the cathode to pass through the second aperture as an electron beam by the anode voltage; an anode-voltage power supply that applies the anode voltage to the anode; and a controller that causes the anode voltage having a positive potential to be applied from the anode-voltage power supply to the anode.

Abstract: A method for filtering a protein-containing liquid containing protein at a concentration of 20 mg/mL or more and 100 mg/mL or less, the method including a prefiltration step of filtering the protein-containing liquid by a prefilter having a pore size of 0.08 ?m to 0.25 ?m and including a hydrophobic resin, and a virus removal step of filtering the protein-containing liquid by a virus removal membrane including a synthetic polymer, after the prefiltration step, wherein the protein-containing liquid before conducting the prefiltration step includes 0.25 g or more of a trimer or higher multimer of the proteins having an average diameter of less than 100 nm, per 1 m2 of the virus removal membrane.

Abstract: A porous membrane comprising a thermoplastic resin, and having a densely structured layer, wherein the ratio of ? crystal strength to ? crystal strength of the thermoplastic resin in the densely structured layer is 5.0 or more.

Abstract: An image forming apparatus includes a rotatable image bearer, an exposure device, a development unit, an adjuster, and a magnetic member. The exposure device forms a latent image on a surface of the image bearer. The developing unit renders the latent image visible with developer including toner and carrier. The adjuster contacts each of the image bearer and the exposure device to regulate a distance between the image bearer and the exposure device. The magnetic member is arranged side by side with the adjuster in a direction of rotation of the image bearer.

Abstract: An image forming apparatus includes a rotatable image bearer, an exposure device, a development unit, an adjuster, and a magnetic member. The exposure device forms a latent image on a surface of the image bearer. The developing unit renders the latent image visible with developer including toner and carrier. The adjuster contacts each of the image bearer and the exposure device to regulate a distance between the image bearer and the exposure device. The magnetic member is arranged side by side with the adjuster in a direction of rotation of the image bearer.

Abstract: Disclosed is a reflective encoder which is capable of measuring movement amount and detecting movement direction by using one emergent light beam, and achieving high reliability and miniaturization through a simple structure. In the reflective encoder, a light beam emitted by a laser oscillator is caused to be incident on a reflective diffraction grating disposed on a side of a scale, and diffracted light beams reflected by the reflective diffraction grating are received by light receiving elements. An interference optical system is provided between the light receiving elements and the reflective diffraction grating. An optical system is thus constructed to measure movement amount and detect movement direction by using only one emergent light beam.

Abstract: A force sensor according to embodiments includes a light-emitting unit, a pair of first light detectors, a reflector, and a first frame. The light-emitting unit emits diffuse light. The first light detectors are arranged in a first direction with the light-emitting unit interposed therebetween. The reflector is arranged to face the light-emitting unit on an optical axis of the light-emitting unit and reflects the diffuse light emitted from the light-emitting unit toward the first light detectors. The first frame is deformed in the first direction so that a reflection range of the diffuse light reflected by the reflector is displaced in the first direction.

Abstract: An image forming apparatus includes an image bearer; a developing device; a transfer device; a waste-developer container; a developer collecting device including a collected-developer conveyor, a waste channel, a reuse channel, and a channel switching member to switch a route between the waste channel and the reuse channel; a switching determiner to determine whether to dispose or reuse collected developer; an operating condition data collector to collect and store operating condition data used as a degradation speed index of developer in the developing device; a determination type selector to select, according to the degradation speed index, one of a first determination type based on an operating amount and a second determination type based on developer replacement data indicating an amount of developer replaced with supplied developer in the developing device; and a switching controller to control the channel switching member according to determination made by the switching determiner.

Abstract: A cleaning device comprises: a to-be-cleaned member; a cleaning member that cleans the surface of the to-be-cleaned member; a conveying member that conveys a substance removed from the surface of the to-be-cleaned member to outside of the device; a rotatable collecting member that conveys with its surface the substance toward the conveying member; and a partitioning member that guides the substance from the collecting member to the conveying member. The collecting member comprises a conveying portion that carries and conveys the substance; and a protrusion that protrudes toward an upstream side of the conveying portion in a rotating direction of the collecting member. One end of the partitioning member faces the rotating collecting member, and the other end faces the conveying member. The conveying portion and the protrusion are brought into contact with the partitioning member by the rotation of the collecting member.

Abstract: The waste toner container includes: a waste toner detection unit configured to detect a state in which a toner surface of waste toner at that position is displaced up to a ceiling portion or near the ceiling portion. The waste toner detection unit includes: a flexibility member installed so as to cover an opening portion formed in the ceiling portion or a side wall and is configured to be deformed by a direct or indirect push by the waste toner; and a movable member formed so as to contact the flexibility member from outside of the container and so as to be displaced by the direct or indirect push by the waste toner interposing the flexibility member such that displacement thereof is detected by a detection unit. The displacement of the movable member is limited by a regulating member.

Abstract: An image forming apparatus that includes an image bearer, a developing device to develop a latent image, a transfer device to transfer a developed image from the image bearer, a developer collecting device to collect developer remaining on the image bearer, and a waste-developer container to contain developer to be disposed. The apparatus also includes a switching determiner to perform a determination of a preferred transfer amount of developer in a target period, an estimation of an accumulative consumption of developer in the target period, a determination of whether to dispose or reuse collected developer, and a determination of whether to perform switching between disposal and reuse of the collected developer based on comparison between the preferred transfer amount and the estimated accumulative consumption of developer. The apparatus also includes a switching controller to cause the developer collecting device to perform the switching between disposal and reuse.

Abstract: An image forming apparatus includes: an image bearer on which a latent image is formed and developed into a toner image; a transfer member that is arranged so as to come in contact with or face the image bearer to form a transfer position; a cleaning unit that removes and collects untransferred toner; a guide member that guides conveyance of the recording medium; a neutralizing light source that irradiates a position downstream of the transfer position and upstream of the cleaning unit in a running direction of the image bearer with neutralizing light which is incident on and reflected by the recording medium sent out from the transfer position and/or the guide member; and a shielding member that blocks light such that the image bearer is not irradiated directly with a part or whole of neutralizing light emitted from the neutralizing light source.

Abstract: An image forming apparatus includes an image bearer; a developing device; a transfer device; a waste-developer container; a developer collecting device including a collected-developer conveyor, a waste channel, a reuse channel, and a channel switching member to switch a route between the waste channel and the reuse channel; a switching determiner to determine whether to dispose or reuse collected developer; an operating condition data collector to collect and store operating condition data used as a degradation speed index of developer in the developing device; a determination type selector to select, according to the degradation speed index, one of a first determination type based on an operating amount and a second determination type based on developer replacement data indicating an amount of developer replaced with supplied developer in the developing device; and a switching controller to control the channel switching member according to determination made by the switching determiner.

Abstract: An image forming apparatus includes: an image bearer on which a latent image is formed and developed into a toner image; a transfer member that is arranged so as to come in contact with or face the image bearer to form a transfer position; a cleaning unit that removes and collects untransferred toner; a guide member that guides conveyance of the recording medium; a neutralizing light source that irradiates a position downstream of the transfer position and upstream of the cleaning unit in a running direction of the image bearer with neutralizing light which is incident on and reflected by the recording medium sent out from the transfer position and/or the guide member; and a shielding member that blocks light such that the image bearer is not irradiated directly with a part or whole of neutralizing light emitted from the neutralizing light source.

Abstract: The waste toner container includes: a waste toner detection unit configured to detect a state in which a toner surface of waste toner at that position is displaced up to a ceiling portion or near the ceiling portion. The waste toner detection unit includes: a flexibility member installed so as to cover an opening portion formed in the ceiling portion or a side wall and is configured to be deformed by a direct or indirect push by the waste toner; and a movable member formed so as to contact the flexibility member from outside of the container and so as to be displaced by the direct or indirect push by the waste toner interposing the flexibility member such that displacement thereof is detected by a detection unit. The displacement of the movable member is limited by a regulating member.

Abstract: A cleaning device comprises: a to-be-cleaned member; a cleaning member that cleans the surface of the to-be-cleaned member; a conveying member that conveys a substance removed from the surface of the to-be-cleaned member to outside of the device; a rotatable collecting member that conveys with its surface the substance toward the conveying member; and a partitioning member that guides the substance from the collecting member to the conveying member. The collecting member comprises a conveying portion that carries and conveys the substance; and a protrusion that protrudes toward an upstream side of the conveying portion in a rotating direction of the collecting member. One end of the partitioning member faces the rotating collecting member, and the other end faces the conveying member. The conveying portion and the protrusion are brought into contact with the partitioning member by the rotation of the collecting member.

Abstract: An image forming apparatus includes an image bearer; a developing device to develop a latent image; a transfer device to transfer a developed image from the image bearer; a developer collecting device to collect developer remaining on the image bearer; a waste-developer container to contain developer to be disposed, a switching determiner to perform determination of a preferred transfer amount of developer in a target period, estimation of an accumulative consumption of developer in the target period, determination of whether to dispose or reuse collected developer collected by the developer collecting device, and determination of whether to perform switching between disposal and reuse of the collected developer based on comparison between the preferred transfer amount and the estimated accumulative consumption of developer; and a switching controller to cause the developer collecting device to perform the switching between disposal and reuse.