Abstract: A therapeutic agent or a preventive agent for alopecia areata has an ROR? antagonistic activity, and, there is a therapeutic agent or a preventive agent for alopecia areata, including a cyclic amine derivative typified by the following compound or a pharmacologically acceptable salt thereof as an active ingredient.

Abstract: A cyclic amine derivative represented by general Formula (I): wherein R1 represents an alkyl group having 1 to 3 carbon atoms; A represents a group represented by general Formula (II-1), (II-2), or (II-3): R2 represents a hydrogen atom or a halogen atom; R3 represents an aryl group or a cycloalkyl group having 4 to 6 carbon atoms, wherein any 1 or 2 hydrogen atoms of the aryl or cycloalkyl group represented by R3 may be each independently substituted with an alkyl group having 1 to 3 carbon atoms or an alkyloxy group having 1 to 3 carbon atoms, and wherein any 1 to 3 hydrogen atoms of the alkyl or alkyloxy group having 1 to 3 carbon atoms which can be a substituent of the aryl or cycloalkyl group may be each independently substituted with a halogen atom; n represents 1 or 2; or a pharmacologically acceptable salt thereof.

Abstract: A therapeutic agent or a preventive agent for alopecia areata has an ROR? antagonistic activity, and, there is a therapeutic agent or a preventive agent for alopecia areata, including a cyclic amine derivative typified by the following compound or a pharmacologically acceptable salt thereof as an active ingredient.

Abstract: A compound has retinoid-related orphan receptor ? antagonist activity and shows a therapeutic effect or a preventive effect on autoimmune diseases such as multiple sclerosis or psoriasis or allergic diseases, including allergic dermatitis or the like, such as contact dermatitis or atopic dermatitis. The cyclic amine derivative is represented by the formula or a pharmacologically acceptable salt thereof.

Abstract: A compound has retinoid-related orphan receptor ? antagonist activity and shows a therapeutic effect or a preventive effect on autoimmune diseases such as multiple sclerosis or psoriasis or allergic diseases, including allergic dermatitis or the like, such as contact dermatitis or atopic dermatitis. The cyclic amine derivative is represented by the formula or a pharmacologically acceptable salt thereof.

Abstract: A magnetic element including a magnetoresistive effect film (MEF). Magnetic element includes an MEF and nonmagnetic spacer layer, first and second ferromagnetic layers, wherein layers being disposed with nonmagnetic spacer layer interposed therebetween, pair of electrodes disposed with MEF interposed therebetween in stacking direction of MEF at least two first soft magnetic layers, coil, and second soft magnetic layer magnetically connected to coil, wherein second soft magnetic layer has ring-like shape, spacing distance between second soft magnetic layer and MEF is larger than first soft magnetic layer and MEF, film thickness of second soft magnetic layer is larger than first soft magnetic layer, part of the two first soft magnetic layers overlaps a part of second soft magnetic layer in stacking direction of MEF, first and second soft magnetic layers are magnetically coupled to each other, and MEF is disposed between respective fore ends of two first soft magnetic layers.

Abstract: A vehicle ceiling includes a roof panel, a ceiling member attached to the roof panel to face toward a vehicle interior and an opening/closing mechanism attached to the ceiling member. The ceiling member is formed with an opening that corresponds with an aperture in the roof panel. The opening/closing mechanism is configured to deploy and reciprocate a sheet member between in a closed state and an open state. The sheet member, in the closed state, covers the opening in the ceiling member to suppress light entrance into the vehicle interior. The sheet member, in the open state, is stowed away from the opening in the ceiling member to permit light entrance into the vehicle.

Abstract: A higher oscillation output is realized in a magnetic element utilizing high frequency characteristics of a magnetoresistive effect element. A magnetic element 1 includes a magnetoresistive effect film 10 including a magnetic pinned layer 14 and a magnetic free layer 12 with a non-magnetic spacer layer 13 interposed therebetween, and a pair of electrodes (lower electrode layer 11 and upper electrode layer 15) arranged with the magnetoresistive effect film 10 interposed therebetween in a stacking direction of the magnetoresistive effect film 10, wherein, given that a minimum value of an area of the magnetic free layer 12 in a section perpendicular to the stacking direction is denoted by Sf, and that a minimum value of an area of the magnetic pinned layer 14 in a section perpendicular to the stacking direction is denoted by Spm, relation of Sf>Spm is satisfied.

Abstract: A magnetic element including a magnetoresistive effect film (MEF). Magnetic element includes an MEF and nonmagnetic spacer layer, first and second ferromagnetic layers, wherein layers being disposed with nonmagnetic spacer layer interposed therebetween, pair of electrodes disposed with MEF interposed therebetween in stacking direction of MEF at least two first soft magnetic layers, coil, and second soft magnetic layer magnetically connected to coil, wherein second soft magnetic layer has ring-like shape, spacing distance between second soft magnetic layer and MEF is larger than first soft magnetic layer and MEF, film thickness of second soft magnetic layer is larger than first soft magnetic layer, part of the two first soft magnetic layers overlaps a part of second soft magnetic layer in stacking direction of MEF, first and second soft magnetic layers are magnetically coupled to each other, and MEF is disposed between respective fore ends of two first soft magnetic layers.

Abstract: This invention relates to: an indole derivative or a pharmaceutically acceptable salt thereof represented by formula (I): wherein R1 is, for example, hydrogen or C1-5 alkyl; R2 is, for example, hydrogen or hydroxy; R3 is, for example, hydrogen or hydroxy; —Z— is a crosslinkage having 2 to 5 carbon atoms; m is an integer from 0 to 3; n is an integer from 0 to 10; R4 and R5 are, for example, fluoro or hydroxy; R9 is, for example, hydrogen or C1-5 alkyl; and R10 and R11 are bound to each other to form, for example, —O—; and a pharmaceutical composition comprising the same, particularly a drug acting on &dgr; opioid receptor.

Abstract: This invention relates to: an indole derivative or a pharmaceutically acceptable salt thereof represented by formula (I): 1