Patents by Inventor Takumi HIRASE

Takumi HIRASE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11898194
    Abstract: A method for detecting a target molecule, including supplying a liquid dispersion of a structural substance including a target molecule into a well array such that the structural substance is introduced into wells of the well array, supplying a sealing solution into the well array such that a layer of the sealing solution is formed on the liquid dispersion in the wells, and that the liquid dispersion is sealed in the wells, extracting the target molecule from the structural substance, and detecting the target molecule.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: February 13, 2024
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi Hirase, Yoichi Makino, Yosuke Horiuchi
  • Publication number: 20220106648
    Abstract: A method for detecting a target molecule of a structure body, including contacting a dispersion liquid including a structure body with a well array including wells such that the structure body is introduced into the wells, bringing a sealing solution into contact with the well array such that the structure body is sealed in at least one of the wells, extracting a content of the structure body in the well, detecting a surface target molecule present on a surface of the structure body in the well, and detecting an internal target molecule present inside the structure body in the well.
    Type: Application
    Filed: November 22, 2021
    Publication date: April 7, 2022
    Applicant: TOPPAN Inc.
    Inventors: Takumi HIRASE, Yoichi MAKINO
  • Publication number: 20200406219
    Abstract: A method of separating a vesicle from a sample may include forming a fusant by fusing a first lipid membrane structure and the vesicle, where the vesicle may include a lipid bilayer membrane, and where the first lipid membrane structure may include a vesicular membrane-fusogenic lipid, and fusing the fusant and a second lipid membrane structure positioned at a predetermined field on a substrate.
    Type: Application
    Filed: September 16, 2020
    Publication date: December 31, 2020
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi HIRASE, Rii MORIMURA, Masato NAKAYAMA
  • Patent number: 10807061
    Abstract: In methods of separating, moving, and detecting a vesicle of the present invention, either a vesicular-shaped lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane, or a lipid-membrane-structure-immobilization carrier, in which a lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane is immobilized on a carrier, is brought into contact with a sample containing the vesicle such that membrane fusion occurs between the lipid membrane structure and the vesicle.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: October 20, 2020
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi Hirase, Rii Morimura, Masato Nakayama
  • Publication number: 20200270674
    Abstract: A method for detecting a target molecule, including supplying a liquid dispersion of a structural substance including a target molecule into a well array such that the structural substance is introduced into wells of the well array, supplying a sealing solution into the well array such that a layer of the sealing solution is formed on the liquid dispersion in the wells, and that the liquid dispersion is sealed in the wells, extracting the target molecule from the structural substance, and detecting the target molecule.
    Type: Application
    Filed: May 12, 2020
    Publication date: August 27, 2020
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi HIRASE, Yoichi MAKINO, Yosuke HORIUCHI
  • Publication number: 20200003691
    Abstract: A device including a well array including wells in which a target substance is detected based on a biochemical reaction thereof. Each of the wells has an aspect ratio of 1 or more as calculated by Formula (1) such that the biochemical reaction of the target substance is detected, Aspect ratio=Depth of each well/Diameter of largest circle among circles included in a region enclosed by a rim of each well??Formula (1).
    Type: Application
    Filed: September 13, 2019
    Publication date: January 2, 2020
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Misaki NAGAHARA, Yoichi MAKINO, Akihiro HOSHINO, Takumi HIRASE, Tomoko KUNITOMI, Keisuke GOTO, Yusuke HORIUCHI
  • Publication number: 20190085385
    Abstract: A method of detecting a target molecule including binding, to first target molecules, specific binding substances which are capable of recognizing different epitopes and labeled with nucleic acid fragments, respectively, detecting the specific binding substances based on fluorescence signals of different fluorescence wavelengths from the nucleic acid fragments, and detecting the first target molecules based on the fluorescence signals that correspond to the specific binding substances, respectively.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 21, 2019
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Yoichi Makino, Takumi Hirase, Noriaki Arai, Hiroyuki Noji
  • Publication number: 20170128904
    Abstract: In methods of separating, moving, and detecting a vesicle of the present invention, either a vesicular-shaped lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane, or a lipid-membrane-structure-immobilization carrier, in which a lipid membrane structure containing a membrane-fusogenic lipid capable of being fused with a vesicle having a lipid bilayer membrane is immobilized on a carrier, is brought into contact with a sample containing the vesicle such that membrane fusion occurs between the lipid membrane structure and the vesicle.
    Type: Application
    Filed: January 23, 2017
    Publication date: May 11, 2017
    Applicant: TOPPAN PRINTING CO., LTD.
    Inventors: Takumi HIRASE, Rii Morimura, Masato Nakayama
  • Patent number: 9632077
    Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: April 25, 2017
    Assignees: TOPPAN PRINTING CO., LTD., TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Takumi Hirase, Masato Nakayama, Hiroshi Handa, Satoshi Sakamoto, Yasuyuki Naito
  • Publication number: 20150125941
    Abstract: A detection system of a test substance, includes: a magnetic body that is modified by a first substance capable of being bound to the test substance at a first binding site of the test substance; a marker that is modified by a second substance capable of being bound to the test substance at a second binding site of the test substance, the second coupling site being a different site from the first binding site; a development medium that has a flow passage into which liquid, in which the magnetic body and the marker is dispersed, flows due to a capillary phenomenon, the development medium having a detection position for detecting the marker in a portion of the flow passage, the development medium having light transparency at least in the detection position; and a magnetic force generating portion that is equipped in the development medium.
    Type: Application
    Filed: January 5, 2015
    Publication date: May 7, 2015
    Applicants: TOPPAN PRINTING CO., LTD., TOKYO INSTITUTE OF TECHNOLOGY
    Inventors: Takumi HIRASE, Masato Nakayama, Hiroshi Handa, Satoshi Sakamoto, Yasuyuki Naito