Abstract: A particle analyzer includes: an upper liquid space for storing first liquid; a lower liquid space for storing second liquid; a connection hole connecting the liquid spaces; a first inlet hole supplying the first liquid to the upper liquid space; a first outlet hole for exhausting air from the upper liquid space; a second inlet hole supplying the second liquid to the lower liquid space; a second outlet hole for exhausting air from the lower liquid space; first and second electrodes respectively applying a potential to the first liquid in the upper liquid space the second liquid in the lower liquid space; first and second lids respectively arranged at the opening of the first outlet hole and at the opening of the second outlet hole, and both lids being formed of a film allowing air to pass but not allowing liquids to pass.

Abstract: A method is provided for producing a bioelectrode capable of reducing potential variation noise due to a polarization voltage. The method for producing the bioelectrode comprises forming an electrically conductive rubber body containing a silicone rubber and a silver powder, and immersing the electrically conductive rubber body in an inorganic salt-containing solution at 70° C. or more and 180° C. or less.

Abstract: A particle separating device includes at least three liquid chambers adapted to store a liquid therein; at least two liquid passages, each connecting adjacent two of the liquid chambers; an inlet adapted to introduce a liquid in which multiple particles of different sizes are dispersed into one of the liquid chambers; and at least two electrodes disposed inside at least two of the liquid chambers, respectively, the electrodes adapted to apply different electrical potentials to the liquid. The cross-sectional areas of the at least two liquid passages are different from each other.

Abstract: A particle analysis device includes a liquid space adapted to store a liquid; a chip disposed above the liquid space, the chip having a connection pore extending vertically and communicating with the liquid space; an upper hole disposed above the chip, the upper hole extending vertically and communicating with the connection pore; a first electrode adapted to apply an electric potential to a liquid in the upper hole; and a second electrode adapted to apply an electric potential to the liquid in the liquid space. The upper hole having a diameter that is equal to or greater than the maximum width of the connection pore, and the entirety of the connection pore falling within the range of the upper hole.

Abstract: A particle analysis device includes multiple stacked plates joined together; an upper liquid space adapted to store a first liquid; a lower liquid space adapted to store a second liquid; a connection pore connecting the upper liquid space to the lower liquid space; a first hole extending from the top surface to the upper liquid space, the first liquid flowing through the first hole; and a second hole extending from the top surface to the lower liquid space, the second liquid flowing through the second hole. A first electrode and a second electrode that are sheets are pinched between two of the plates. The first electrode applies an electric potential to the first liquid in the upper liquid space through the first hole, whereas the second electrode applies an electric potential to the second liquid in the lower liquid space through the second hole.

Abstract: A method is provided for manufacturing a particle analyzer in which the deterioration of the measurement function is suppressed during the measurement of the particles to be measured. The particle analyzer includes a first storage chamber in which a first liquid is stored, a second storage chamber in which a second liquid containing particles to be analyzed is stored, and a flow path connecting the first storage chamber in fluid communication with the second storage chamber. The method includes a surface modification step of irradiating a surface constituting the flow path with an ultraviolet ray to modify the surface of the flow path.

Abstract: A particle analysis device includes an upper liquid space in which a first liquid is stored, a lower liquid space in which a second liquid is stored, a connection pore connecting the upper liquid space to the lower liquid space, and first to fourth holes. Each of the first to fourth holes has an opening that opens at a top surface of the particle analysis device. The first and second holes extend to the upper liquid space. The third and fourth holes extend to the lower liquid space. A first electrode applies an electric potential to the first liquid in the upper liquid space through the first hole, and a second electrode applies an electric potential to the second liquid in the lower liquid space through the third hole. The opening of at least one of the first hole and the second hole has an area that is greater than the rest of the hole. The opening of at least one of the third hole and the fourth hole has an area that is greater than the rest of the hole.

Abstract: A method is provided for storing a particle analyzer capable of suppressing deterioration of a measurement performance with the lapse of time in a particle analyzer for analyzing particles such as exosomes, pollen, viruses, and bacteria. The particle analyzer has a first storage chamber in which a first liquid is stored, a second storage chamber in which a second liquid containing particles to be analyzed is stored, and a flow path connecting the first storage chamber in fluid communication with the second storage chamber. According to the method, at least a portion of the first storage chamber, the second storage chamber, and the flow path are surface-treated, which includes filling an internal space defined by the first storage chamber, the second storage chamber, and the flow path with a liquid to thereby store the particle analyzer in a state that the surface-treated portion is not in contact with air.

Abstract: A bioelectrode includes a support member, an electrode member of conductive rubber, including a supported part that is a member to be supported by the support member and at least one electrode part that is a member protruding from the supported part, and a snap-button-type connector that is provided on the support member, and that electrically connects the electrode member to outside. The snap-button-type connector and the supported part are integrally molded.

Abstract: A microfluidic chip is inserted into a slot that extends horizontally, and is used as a microfluidic device. The microfluidic chip includes an upper surface, a lower surface opposite the upper surface, a flow passage for fluid located between the upper surface and the lower surface, and two communication holes communicating with the flow passage and opening at the upper surface.

Abstract: A microfluidic chip includes an upper surface, a lower surface opposite the upper surface, a flow passage for fluid located between the upper surface and the lower surface, a communication hole that communicate with the flow passage and open at the upper surface or the lower surface, and an annular seal formed from an elastomer, the annular seal being placed in contact with or being formed on the upper surface or the lower surface at which the communication hole opens and surrounding the communication hole. The microfluidic chip further includes a support structure fixed at a position within the flow passage, the position overlapping the annular seal, the support structure securing a height of the flow passage so as to prevent blockage of the flow passage.

Abstract: A bioelectrode and a method for producing the bioelectrode are provided. The bioelectrode has a non-complicated structure, satisfactory elasticity, and is capable of preventing an increase of contact impedance due to an increase of the number of times of usage. The bioelectrode includes a support member, which is an electrically conductive member, and at least one electrode member, which is a member projecting from the support member. At least the electrode member is molded from an electrically conductive rubber containing a silicone rubber and treated metal particles containing a crosslinkable functional group on a surface thereof.

Abstract: A bioelectrode includes a support member and at least one electrode member. The support member is a conductive member, and the electrode member is a member projecting from the support member. The at least one electrode member is molded from a conductive rubber containing a silicone rubber and metal particles, and the electrode member has an exposed face, which is a face formed by removal of a molded surface layer at a tip end.

Abstract: A method is provided for producing a bioelectrode capable of reducing potential variation noise due to a polarization voltage. The method for producing the bioelectrode comprises forming an electrically conductive rubber body containing a silicone rubber and a silver powder, and immersing the electrically conductive rubber body in an inorganic salt-containing solution at 70° C. or more and 180° C. or less.