Patents by Inventor Takuo Aoyagi

Takuo Aoyagi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8548546
    Abstract: A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: October 1, 2013
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Michio Kanemoto, Masayoshi Fuse, Teiji Ukawa
  • Patent number: 8423107
    Abstract: A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.
    Type: Grant
    Filed: June 18, 2009
    Date of Patent: April 16, 2013
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Michio Kanemoto, Masayoshi Fuse, Teiji Ukawa
  • Patent number: 8024021
    Abstract: To measure oxygen saturation in blood, living tissue is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the tissue. The first electrical signal is divided into a plurality of first segments, each including a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments, each including a part of the second electrical signal for the predetermined time period. A gradient of a regression line is calculated between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.
    Type: Grant
    Filed: August 29, 2006
    Date of Patent: September 20, 2011
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Naoki Kobayashi
  • Publication number: 20090318787
    Abstract: A pulse oximetry includes: irradiating living tissue with a plurality of light beams of different wavelengths; receiving the light beams transmitted through or reflected from the living tissue and converting the received light beams to electric signals which correspond to the different wavelengths; time-segmenting time series data of the electric signals; calculating, with respect to each of the segmented time series data of the electric signals, a slope value of a regression line between each two of the electric signals; calculating SaO2 based on the slope value of each of the segmented time series data of the electric signals; constructing a histogram of SaO2 for each predetermined number of time segments; and obtaining a mode value from the histogram as SpO2 to be output of the pulse oximetry.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 24, 2009
    Applicant: NIHON KOHDEN CORPORATION
    Inventors: Takuo AOYAGI, Michio KANEMOTO, Masayoshi FUSE, Teiji UKAWA
  • Patent number: 7206621
    Abstract: In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: April 17, 2007
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Naoki Kobayashi, Teiji Ukawa
  • Publication number: 20070049812
    Abstract: In order to measure an oxygen saturation in blood of a subject, a living tissue of the subject is irradiated with a first light beam having a first wavelength and a second light beam having a second wavelength different from the first wavelength. A first electrical signal is generated from the first light beam reflected from or transmitted through the living tissue. A second electrical signal is generated from the second light beam reflected from or transmitted through the living tissue. The first electrical signal is divided into a plurality of first segments each of which includes a part of the first electrical signal for a predetermined time period. The second electrical signal is divided into a plurality of second segments each of which includes a part of the second electrical signal for the predetermined time period. It is calculated a gradient of a regression line between every one of the first segments and an associated one of the second segments, thereby obtaining a plurality of gradients.
    Type: Application
    Filed: August 29, 2006
    Publication date: March 1, 2007
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Naoki Kobayashi
  • Publication number: 20050049469
    Abstract: In a pulse oximeter for obtaining an oxygen saturation in a blood, a light emitter irradiates a living tissue with light beams having five different wavelengths. A light receiver receives respective light beams reflected from or transmitted through the living tissue, and converts the received light beams to electric signals. A first calculator calculates five attenuation changes of the living tissue based on fluctuations of the respective electric signals. A second calculator calculates at least four attenuation change ratios from the five attenuation changes. Each of the attenuation change ratios is defined by a ratio between any two of the five attenuation changes. A third calculator calculates the oxygen saturation based on the attenuation change ratios, while taking an oxygen saturation of arterial blood, an oxygen saturation of venous blood, a ratio between changes in arterial blood and venous blood, and a tissue term as four unknown values.
    Type: Application
    Filed: August 27, 2004
    Publication date: March 3, 2005
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Naoki Kobayashi, Teiji Ukawa
  • Patent number: 6671526
    Abstract: A probe 1 includes a light irradiating device 2 and a light receiving device 3, which are oppositely disposed sandwiching living tissue 10. The light irradiating device 2 includes a light source 5 and a scattering plate 6 located in front of the light source 5. The light receiving device 3 includes a photo diode 8 and a light scattering portion. With such an arrangement, of the attenuation of the living tissue 10, non-absorbing attenuation is free from the wavelength. A ratio of absorbing attenuation and a thickness of a blood layer is not affected by a thickness of living tissue. Further, the absorbing attenuation is not dependent on a depth of the blood layer.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: December 30, 2003
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Sunao Takeda, Cheng-tai Xie, Michio Kanemoto
  • Patent number: 6230035
    Abstract: Irradiating device 3 of a pulse oximeter includes a scattering plate 6. Scattering light is projected into a living tissue. The diameter of the incident area is sufficiently large compared with that of a light receiving area or vice versa. Therefore, tissue terms in a theoretical formula of &PHgr; which represents a ratio of changes of optical densities of tissue measured with two wavelengths are not dependent on the wavelength. The digital processor 10 calculates an oxygen saturation by substituting &PHgr; measured into simultaneous equations.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: May 8, 2001
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Chen-tai Xie, Michio Kanemoto
  • Patent number: 5999841
    Abstract: Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
    Type: Grant
    Filed: August 22, 1997
    Date of Patent: December 7, 1999
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Michio Kanemoto, Naoki Kobayashi
  • Patent number: 5766125
    Abstract: Light beams of different wavelengths, emitted from a light generating device, are transmitted through a living tissue. The transmitted light beams are converted into electrical signals by a photoelectric transducing device. A pulsation calculating device calculates a pulsation of an absorbance of tissue of a living tissue for each wavelength on the basis of the output signal of the photoelectric transducing device. By using this, a pulsation ratio calculating device calculates the ratio of the pulsations of the absorbance values. A concentration calculating device puts the output signal of the pulsation ratio calculating device into a formula having a single unknown on the tissue term, which is constructed on the basis of the fact that a predetermined relation is present between the tissue terms of the respective wavelengths, thereby calculating a value of the tissue term and the concentration of light absorbing material in blood.
    Type: Grant
    Filed: April 27, 1995
    Date of Patent: June 16, 1998
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Michio Kanemoto, Cheng-tai Xie, Naoki Kobayashi, Hideaki Hirahara
  • Patent number: 5720284
    Abstract: Light of various wavelengths emitted from light sources and transmitted through vital tissues is converted by light sensors and current/voltage transducers, into electric signals. The signals are converted into digital values by an A/D converter. The light source emits light of a wavelength which can be optically absorbed by water. A computer obtains a ratio of variations of the digital values for each wavelength, and calculates the values of tissue terms and the hemoglobin concentration on the basis of the ratios. In the calculation, since tissue terms of the wavelengths have mutual constant relationships, an equation which is prepared so that there exists only one unknown in the tissue terms is used.
    Type: Grant
    Filed: March 29, 1996
    Date of Patent: February 24, 1998
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Michio Kanemoto, Cheng Tai Xie
  • Patent number: 5697371
    Abstract: Using the principle of pulse oximetry, the relationship between the logarithm of dye density and the passage of time is obtained to determine a regression line for the linear portion of the relationship; an intial dye density in the blood is determined for the point of time that defines the mean transit time for the initial circulation of the injected dye on the regression line; and the circulating blood volume is calculated from the thus determined initial dye density.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: December 16, 1997
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Michio Kanemoto, Naoki Kobayashi
  • Patent number: 5690104
    Abstract: Intensities of light of two different wavelengths transmitted through a tissue of a living body are measured during a first time period. A data processor determines a first regression line using logarithmically processed data corresponding to the light intensities measured during the first time period. An operator injects a dye into the living body and measurements of intensities of light at the two different wavelengths are made during a later time period. The data processor determines a second regression line using logarithmically processed data corresponding to the light intensities measured during the later time period. The data processor finds an intersection of the two regression lines and uses the intersection to determine a bloodless level point. The processor then forms a dye dilution curve incorporating the bloodless level point data.
    Type: Grant
    Filed: June 10, 1996
    Date of Patent: November 25, 1997
    Assignee: Nihon Kohden Corporation
    Inventors: Michio Kanemoto, Naoki Kobayashi, Takuo Aoyagi
  • Patent number: 5666952
    Abstract: A supporting shaft stands on an external auditory canal arm holding an LED. An attaching portion holding a PD is rotatably connected to one end of a holding arm. A column having a through hole 11b into which the supporting shaft is slidably inserted is fixed to the other end of the holding arm. The external auditory canal arm and the holding arm are connected to each other by a coil spring.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: September 16, 1997
    Assignee: Nihon Kohden Corporation
    Inventors: Masayoshi Fuse, Takuo Aoyagi
  • Patent number: 5385143
    Abstract: Disclosed is an apparatus for measuring a predetermined data of a living tissue, such as an oxygen saturation, a dye dilution curve and level of hemoglobin. The apparatus has an illumination intensity computing and storing circuit that stores the intensities of light components emitted from a three-wavelength light source assembly, and a computing circuit that calculates the intensity ratios of illuminating light from the intensity data stored in the circuit. The circuit determines the predetermined data of blood on the basis of the calculated intensity ratios and the intensities of light transmitted through a living tissue under assay, and it displays the predetermined data on display unit. The apparatus is capable of measuring the predetermined data without relying upon pulsations that occur in the subject.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: January 31, 1995
    Assignee: Nihon Kohden Corporation
    Inventor: Takuo Aoyagi
  • Patent number: 5313940
    Abstract: A photo-electric pulse measuring probe includes a pair of supporting members which have a light emitting element and a light receiving element adjacent first end portions thereof, respectively, in such a manner that the light emitting element and the light receiving elements are confronted with each other, and which are swingably coupled to each other at the other end portions thereof. The light emitting element and the light receiving element are covered with elastic members, respectively, and wavy surfaces are formed in the mating surfaces of the elastic members, respectively, so that a user's finger is supported by a number of points during measurement.
    Type: Grant
    Filed: May 14, 1992
    Date of Patent: May 24, 1994
    Assignee: Nihon Kohden Corporation
    Inventors: Masayoshi Fuse, Cheng T. Xie, Takuo Aoyagi
  • Patent number: 5278627
    Abstract: An apparatus for calibrating a pulse oximeter which can improve the repetitivity of measured values for calibration tests and which can calibrate the pulse oximeter with a high reliability. A tissue model having a light-absorbing characteristic approximated to that of the tissue of a living body is inserted into a space between a light-emitting section and a light-receiving section of a measuring probe that is connected to the pulse oximeter, and a blood model having a light-absorbing characteristic that is approximated to that of the blood is moved within the tissue model so as to enter into or exit from the space between the light-emitting section and the light-receiving section.
    Type: Grant
    Filed: February 14, 1992
    Date of Patent: January 11, 1994
    Assignee: Nihon Kohden Corporation
    Inventors: Takuo Aoyagi, Masayoshi Fuse, Yoshiaki Shindo, Masayuki Kato
  • Patent number: 5190040
    Abstract: An apparatus for measuring the change in the concentration of a pigment in blood is disclosed which comprises: light quantity detecting units for continuously detecting the quantities of radiations of light having different wavelengths that have been transmitted or reflected by living tissue containing pulsating blood; first computing unit which, when the concentration or absorptivity coefficient of a light-absorbing component in the blood changes with respect to light having either one of said wavelengths, computes the quantities of radiations of transmitted or reflected light having the wavelengths when the living tissue is in a state of ischemia on the basis of the constant and pulsating components of the quantity of each radiation of light that has been detected by the light quantity detectors both before and after the change occurred; and second computing unit which continuously determines the concentration of a pigment of interest in the blood by performing calculations based on the results of computati
    Type: Grant
    Filed: August 12, 1991
    Date of Patent: March 2, 1993
    Assignee: Nihon Kohden Corporation
    Inventor: Takuo Aoyagi
  • Patent number: 4964010
    Abstract: An electronic device including a circuit element to which a pulse current is applied, and a device for limiting the time integration value of current flowing in the circuit element, the device being connected in series to the circuit element, to prevent the circuit element from being overheated.
    Type: Grant
    Filed: November 16, 1989
    Date of Patent: October 16, 1990
    Assignees: Katsuyuki Miyasaka, Nihon Kohden Corporation
    Inventors: Katsuyuki Miyasaka, Takuo Aoyagi