Patents by Inventor Takuo KAWASE

Takuo KAWASE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for purifying antibody having low isoelectric point
    Patent number: 10654933
    Abstract: The present inventors discovered that additional aggregation of low-pI antibody can be suppressed by removing formed antibody aggregates after a certain period of time following Protein A column purification, acidic treatment, and neutralization. Furthermore, the present inventors found that efficient impurities removal for a low-pI antibody can be accomplished by using an anion exchange resin in the Bind/Elute mode and then a hydrophobic interaction chromatography or multimodal chromatography resin, compared with conventional methods.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: May 19, 2020
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yasufumi Ueda, Shohei Kobayashi, Satoko Yanagita, Takuo Kawase, Masahiro Fukunaga
  • METHOD FOR PURIFYING ANTIBODY HAVING LOW ISOELECTRIC POINT
    Publication number: 20160326253
    Abstract: The present inventors discovered that additional aggregation of low-pI antibody can be suppressed by removing formed antibody aggregates after a certain period of time following Protein A column purification, acidic treatment, and neutralization. Furthermore, the present inventors found that efficient impurities removal for a low-pI antibody can be accomplished by using an anion exchange resin in the Bind/Elute mode and then a hydrophobic interaction chromatography or multimodal chromatography resin, compared with conventional methods.
    Type: Application
    Filed: December 26, 2014
    Publication date: November 10, 2016
    Applicant: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yasufumi UEDA, Shohei KOBAYASHI, Satoko YANAGITA, Takuo KAWASE, Masahiro FUKUNAGA