Patents by Inventor Takuo Nakano
Takuo Nakano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5304555Abstract: This invention provides novel pyrimidines or their pharmaceutically acceptable salts thereof and process for preparation thereof. The novel compounds are useful for neurological diseases of the peripheral and central nervous systems of animals.Type: GrantFiled: October 19, 1990Date of Patent: April 19, 1994Assignees: Mitsui Petrochemical Industries, Ltd., Mitsui Pharmaceuticals, Inc.Inventors: Akira Awaya, Kazutoshi Horikomi, Tadayuki Sasaki, Hisashi Kobayashi, Akira Mizuchi, Takuo Nakano, Ikuo Tomino, Shintaro Araki, Mitsuyuki Takesue, Koji Kato, Keiichi Yokoyama
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Patent number: 5192799Abstract: Amine represented by the following formula (1), or their acid addition salts or their quaternary ammonium salts. ##STR1## The amines of formula (1) or their pharmaceutically acceptable acid addition salts or quaternary ammonium salts are useful for the treatment and prevention of heart diseases of animals, particularly arrhythima, myocardial infarction, angina pectoris and heart failure and psychoneurological diseases.Type: GrantFiled: June 5, 1992Date of Patent: March 9, 1993Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Ikuo Tomino, Masaharu Ishiguro, Takumi Kitahara, Keiichi Yokoyama, Noriaki Kihara, Joji Kamiya, Kanji Yoshihara, Masaaki Ishii, Akira Mizuchi, Kazutoshi Horikomi, Akira Awaya, Takuo Nakano
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Patent number: 4965263Abstract: This invention relates to pyridazinone derivatives of the general formula: ##STR1## [wherein R.sup.1 stands for a hydrogen atom or a lower alkyl group; R.sup.2 for a hydrogen atom or a lower alkyl group; and A for (i) a ring selected from a benzene ring, a furan ring, a thiophene ring and a pyridine ring (on which ring 1-3 substituents or atoms selected from amino groups, nitro groups, lower alkanoylamino groups, hydroxyl groups, lower alkanoyloxy groups, sulfamoyl groups and halogen atoms may be present), or (ii) a grouping of the formula: ##STR2## (wherein R.sup.3 stands for a hydrogen atom, a lower alkyl group, a phenyl(lower)alkyl, a hydroxyphenyl(lower)alkyl group, a lower alkylmercapto(lower)alkyl group, a benzylmercapto(lower)alkyl group, a guanidino(lower)alkyl group, a nitroguanidino(lower)alkyl group, an indolyl(lower)alkyl group, a carbamoyl(lower)alkyl group or a carboxy(lower)alkyl group, R.sup.4 for a hydrogen atom or a lower alkyl group, R.sup.Type: GrantFiled: February 14, 1989Date of Patent: October 23, 1990Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takuo Nakano
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Patent number: 4959368Abstract: A pharmaceutical composition comprising a pyrimidine represented by the following formula ##STR1## wherein R.sup.1 represents a hydrogen atom, an acyl group having 2 to 4 carbon atoms, an alkoxycarbonyl group having 2 to 5 carbon atoms, an alkoxycarbonylmethyl group having 3 to 5 carbon atoms, a 3,4-dimethoxybenzoyl group or a 3,4-methylenedioxybenzyl group,R.sup.2 represents a hydrogen atom, an amino group, a monoalkylamino group having 1 to 4 carbon atoms, an alkoxy group having 1 to 5 carbon atoms or an alkoxycarbonyl group having 2 to 4 carbon atoms,R.sup.3 represents a hydrogen atom, an alkoxycarbonyl group having 2 to 4 carbon atoms, a dialkylaminocarbonyl group having 1 to 9 carbon atoms in each alkyl moiety, an alkoxy group having 1 to 5 carbon atoms, or a hydroxyethyl group, R.sup.2 and R.sup.3, together with the carbon atoms to which they are bonded, may form a 5- to 7-membered carbocyclic ring or a heterocyclic ring having N, O or S as the hetero atom, and R.sup.Type: GrantFiled: October 22, 1987Date of Patent: September 25, 1990Assignees: Mitsui Petrochemical Industries Ltd., Mitsui Pharmaceuticals, Inc.Inventors: Akira Awaya, Takuo Nakano, Hisashi Kobayashi, Ken E. Tan, Kazutoshi Horikomi, Tadayuki Sasaki, Keiichi Yokoyama, Hiroyasu Ohno, Kozi Kato, Takumi Kitahara, Ikuo Tomino, Shigeru Isayama
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Patent number: 4734418Abstract: Disclosed herein is an antihypertensive preparation containing, as an active component, a novel quinazoline derivative represented by the following general formula or a salt thereof: ##STR1## wherein R.sup.100 means a hydrogen atom or methoxy group, R.sup.200 and R.sup.300 denote individually a hydrogen atom or lower alkoxy group, R.sup.400 is a hydrogen atom or amino group, l stands for 2 or 3, and Het is a specific hetero ring group.Type: GrantFiled: December 6, 1985Date of Patent: March 29, 1988Assignee: Mitsui Petrochemical Industries, Ltd.Inventors: Keiichi Yokoyama, Koji Kato, Takumi Kitahara, Hiroyasu Ohno, Takashi Nishina, Mikio Kumakura, Akira Awaya, Takuo Nakano, Kazuyuki Watanabe, Sakae Saruta
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Patent number: 4639451Abstract: This invention relates to pyridazinone derivatives of the general formula: ##STR1## [wherein R.sup.1 stands for a hydrogen atom or a lower alkyl group; R.sup.2 for a hydrogen atom or a lower alkyl group; and A for (i) a ring selected from a benzene ring, a furan ring, a thiophene ring and a pyridine ring (on which ring 1-3 substituents or atoms selected from amino groups, nitro groups, lower alkanoylamino groups, hydroxyl groups, lower alkanoyloxy groups, sulfamoyl groups and halogen atoms may be present), or (ii) a grouping of the formula: ##STR2## (wherein R.sup.3 stands for a hydrogen atom, a lower alkyl group, a phenyl(lower)alkyl, a hydroxyphenyl(lower)alkyl group, a lower alkylmercapto(lower)alkyl group, a benzylmercapto(lower)alkyl group, a guanidino(lower)alkyl group, a nitroguanidino(lower)alkyl group, an indolyl(lower)alkyl group, a carbamoyl(lower)alkyl group or a carboxy(lower)alkyl group, R.sup.4 for a hydrogen atom or a lower alkyl group, R.sup.Type: GrantFiled: June 3, 1983Date of Patent: January 27, 1987Assignee: Mitsui Toatsu Kagaku-Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano
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Patent number: 4532137Abstract: Disclosed are 2-thiazol derivatives having the general formula ##STR1## where R.sub.1 and R.sub.2 independently represent lower alkyl radicals having 1 to 4 carbon atoms and X represents a lower alkyl radical, a lower alkoxy radical, a lower alkoxycarbonyl radical, a halogenoalkoxy radical, a radical of the formula ##STR2## or a radical of the formula ##STR3## Also disclosed are a process for preparing the derivatives and pharmaceutical compositions having immunomodulatory activity which comprise the derivatives as the active ingredient.Type: GrantFiled: January 6, 1984Date of Patent: July 30, 1985Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Isao Sakano, Tatsuro Yokoyama, Seitaro Kajiya, Yutaka Okazaki, Hiroshi Tokuda, Hiroshi Kawazura, Mikio Kumakura, Takuo Nakano, Akira Awaya
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Patent number: 4523011Abstract: 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## between them to form the structure: ##STR4## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.Type: GrantFiled: March 28, 1984Date of Patent: June 11, 1985Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano
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Patent number: 4521415Abstract: 6-(Substituted phenyl)-4,5-dihydro-3(2H)-pyridazinone compounds possessing strong platelet aggregation inhibiting activity and blood pressure depressing activity, having the general formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl; R.sup.2 is hydrogen, lower alkyl, lower alkylthio or the grouping R.sup.5 --NH-- where R.sup.5 is lower alkyl; R.sup.3 is phenyl, pyridyl, benzyl, lower alkyl or a substituted phenyl group carrying at any desired position on the benzene ring thereof the grouping: ##STR2## where R.sup.1 has the same meaning as given above; R.sup.4 is hydrogen or halogen; n is 0 or 1; and when both R.sup.2 and R.sup.3 are lower alkyl groups, R.sup.2 and R.sup.3 may be combined together with the bridging member ##STR3## where m is 2 or 3, as well as physiologically acceptable acid-addition salts thereof, and processes for preparing them.Type: GrantFiled: December 28, 1982Date of Patent: June 4, 1985Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Tsutomu Katakami, Nobuyuki Fukazawa, Hajime Iizuka, Takashi Nishina, Joji Kamiya, Yasuhito Tanaka, Takuo Nakano
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Patent number: 4511574Abstract: The present invention provides new chemical compounds, N-(4-phenyl-2-thiazolyl)carbamate derivatives, a process for preparing the same and pharmaceutical compositions containing the carbamate derivatives. More particularly, the present invention provides N-(4-phenyl-2-thiazolyl)carbamate derivatives which have immuno-modulating activity and are thus effective against immunodiseases such as chronic rheumatoid arthritis and also useful against viral diseases or for the immunotherapy of cancers with low toxicity.Type: GrantFiled: September 8, 1982Date of Patent: April 16, 1985Assignee: Mitsui Toatsu Kagaku Kabushiki KaishaInventors: Isao Sakano, Tatsuro Yokoyama, Seitaro Kajiya, Yutaka Okazaki, Hiroshi Tokuda, Hiroshi Kawazura, Mikio Kumakura, Takuo Nakano, Akira Awaya
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Patent number: 4501750Abstract: The present invention provides new thiazole compounds possessing immuno-modulating activity, i.e. thiazole compounds of the general formula (1): ##STR1## wherein R.sub.1 stands for a hydrogen or halogen atom or a lower alkyl, lower alkoxy, substituted or unsubstituted phenoxy, nitro or cyano group, R.sub.2 for a hydrogen atom or a lower alkyl or lower alkylthio group, and R for an .alpha.-halogenoalkyl group or the grouping: ##STR2## a process for preparing same and pharmaceutical compositions containing the thiazole compounds.Type: GrantFiled: September 13, 1982Date of Patent: February 26, 1985Assignee: Mitsui Toatsu Kaguku Kabushiki KaishaInventors: Isao Sakano, Tatsuro Yokoyama, Seitaro Kajiya, Yutaka Okazaki, Hiroshi Tokuda, Hiroshi Kawazura, Mikio Kumakura, Takuo Nakano, Akira Awaya
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Patent number: 4490393Abstract: The present invention provides thiazolyl derivatives as new chemical substance represented by the general formula: ##STR1## wherein R.sup.1 stands for a lower alkyl group or a substituted or unsubstituted phenyl group, R.sup.2 for a hydrogen atom, a lower alkyl, lower alkoxy or lower alkylthio group, and R.sup.3 for a pyridyl or iso-oxazolyl group or a grouping of the general formula: ##STR2## processes for preparing same and pharmaceutical compositions containing the thiazolyl derivatives. More particularly, the present invention provides new thiazolyl derivatives which possess immuno-modulating activity and are thus therapeutically effective against immunodiseases such as chronic rheumatoid arthritis and also useful against viral diseases or for the immunotherapy of cancers and possess properties desirous as medicines with a slight toxicity, processes for preparing same and pharmaceutical compositions containing the new substance.Type: GrantFiled: September 17, 1982Date of Patent: December 25, 1984Assignee: Mitsui Toatsu Kagaki Kabushiki KaishaInventors: Isao Sakano, Tatsuro Yokoyama, Seitaro Kajiya, Tamotsu Minami, Yutaka Okazaki, Hiroshi Tokuda, Hiroshi Kawazura, Mikio Kumakura, Takuo Nakano, Akira Awaya
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Patent number: 4476128Abstract: The present invention relates to a piperazine compound represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom or a phenyl group, R.sup.1 stands for a hydrogen atom or an alkyl group, and R.sup.2 stands for a hydrogen atom or an alkyl group.These compounds are valuable as immunopotentiators, such as for the treatment of chronic rheumatoid arthritis and other diseases accompanied by reduction or abnormal change of the immune function.Type: GrantFiled: January 13, 1983Date of Patent: October 9, 1984Assignee: Mitsuitoatsu Chemicals, Inc.Inventors: Isao Sakano, Shiyoichiro Miyahara, Yoshitsugu Yamada, Yutaka Okazaki, Hiroshi Tokuda, Akira Awaya, Takuo Nakano
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Patent number: 4473577Abstract: Disclosed are 2-thiazol derivatives having the general formula ##STR1## where R.sub.1 and R.sub.2 independently represent lower alkyl radicals having 1 to 4 carbon atoms and X represents a lower alkyl radical, a lower alkoxy radical, a lower alkoxycarbonyl radical, a halogenoalkoxy radical, a radical of the formula ##STR2## or a radical of the formula ##STR3## Also disclosed are a process for preparing the derivatives and pharmaceutical compositions having immunomodulatory activity which comprise the derivatives as the active ingredient.Type: GrantFiled: October 22, 1982Date of Patent: September 25, 1984Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Isao Sakano, Tatsuro Yokoyama, Kajiya Seitaro, Yutaka Okazaki, Hiroshi Tokuda, Hiroshi Kawazura, Mikio Kumakura, Takuo Nakano, Akira Awaya
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Patent number: 4376119Abstract: N-(6-fluoro-2-pyridyl)-3,4-dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-ca rboxamide 1,1-dioxide that is a novel benzothiazine derivative. The compound is characterized by a low degree of toxicity and a low incidence of gastric disorders and useful as an anti-inflammatory agent.Type: GrantFiled: June 16, 1981Date of Patent: March 8, 1983Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Shoichiro Ozaki, Hideya Kobayashi, Haruki Mori, Hiroshi Kawazura, Yutaka Okazaki, Takafumi Kitano, Mikio Kumakura, Takuo Nakano
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Patent number: 4296112Abstract: A cephalosporanic acid of the general formula ##STR1## wherein A represents ##STR2## and the pharmaceutically acceptable salt and ester thereof.Type: GrantFiled: December 17, 1979Date of Patent: October 20, 1981Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Akira Matsubara, Hideaki Sakai, Makoto Odate, Toshio Suganuma, Takuo Nakano
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Patent number: 4283398Abstract: A cephalosporanic acid of the general formula ##STR1## wherein Y represents a hydrogen atom or a hydroxyl group, and the biologically acceptable salt and ester thereof.Type: GrantFiled: November 26, 1979Date of Patent: August 11, 1981Assignee: Mitsui Toatsu Chemicals, Inc.Inventors: Akira Matsubara, Hideaki Sakai, Toshio Suganuma, Nobuyuki Fukazawa, Takuo Nakano
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Patent number: 4273932Abstract: Disclosed is a quinoline derivative having the general formula ##STR1## where A represents a six-membered hydrocarbon ring; X represents an oxygen atom, an .dbd.NOR.sup.1 group in which R.sup.1 is a hydrogen atom or a lower alkyl radical of from 1 to 5 carbon atoms, a hydroxyl group, or an --NHR.sup.2 group in which R.sup.2 is a hydrogen atom or an acyl group; and Y represents a hydrogen atom, a salt-forming radical, or an ester-forming radical. This quinoline derivative is a novel compound which has antiallergic effects in itself and is useful as an intermediate in the production of penicillin or cephalosporin derivatives.Type: GrantFiled: January 29, 1980Date of Patent: June 16, 1981Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Akira Matsubara, Hideaki Sakai, Makoto Odate, Takuo Nakano
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Quinolinecarboxylic acid substituted penicillins and pharmaceutical compositions containing the same
Patent number: 4263302Abstract: A penicillanic acid of the general formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 each represent a hydrogen atom or a lower alkyl group, provided that R.sup.1, R.sup.2 and R.sup.3 do not simultaneously represent a hydrogen atom, or a biologically acceptable salt thereof.Type: GrantFiled: November 20, 1979Date of Patent: April 21, 1981Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Akira Matsubara, Hideaki Sakai, Takuo Nakano, Toshio Suganuma