Patents by Inventor Takuo Tsukuda

Takuo Tsukuda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Remedy for viral disease
    Publication number: 20060217434
    Abstract: The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also only demonstrate mild cytotoxicity in vivo, a pharmaceutical composition containing the compound of the present invention is extremely useful as an anti-HCV preventive/therapeutic agent.
    Type: Application
    Filed: February 12, 2004
    Publication date: September 28, 2006
    Inventors: Masahiro Aoki, Hideyuki Kato, Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki
  • Compound having anti-hcv activity and process for producing the same
    Publication number: 20060194870
    Abstract: The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its having a high degree of replication inhibitory activity against HCV, its production method, an intermediate compound useful for its production and a pharmaceutical composition containing these compounds, and the present invention relates to a compound represented by the formula (I): (wherein A represents —(CH2)n—, etc.; B represents —(C?O)—, etc.; D represents —(CH2)m—R?, etc.; E represents a hydrogen atom, etc.; G represents —(CH2)p-J, etc.; bond Q represents a single bond or double bond; and R1, R2 and R3 may be the same or different and each represent a hydrogen atom, etc.), a prodrug thereof or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: July 9, 2004
    Publication date: August 31, 2006
    Inventors: Masayuki Sudoh, Takuo Tsukuda, Miyako Masubuchi, Kenichi Kawasaki, Takeshi Murata, Fumio Watanabe, Hiroshi Fukuda, Susumu Komiyama, Tadakatsu Hayase
  • 4'-Substituted nucleoside derivatives as inhibitors of HCV RNA replication
    Publication number: 20040266722
    Abstract: The present invention relates to the use of nucleoside derivatives of formula I 1
    Type: Application
    Filed: July 15, 2004
    Publication date: December 30, 2004
    Inventors: Rene Robert Devos, Christopher John Hobbs, Wen Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera, Nobuo Shimma, Takuo Tsukuda
  • 4?-substituted nucleoside derivatives as inhibitors of HCV RNA replication.
    Patent number: 6784166
    Abstract: The present invention relates to the use of nucleoside derivatives of formula I wherein B signifies a 9-purinyl residue B1 of formula or a 1-pyrimidyl residue B2 of formula wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof; for the treatment of diseases mediated by the Hepatitis C Virus (HCV), for the preparation of a medicament for such treatment and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 31, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Rene Robert Devos, Christopher John Hobbs, Wen Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera, Nobuo Shimma, Takuo Tsukuda
  • Anti-HCV nucleoside derivatives
    Publication number: 20040110718
    Abstract: The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.
    Type: Application
    Filed: October 3, 2003
    Publication date: June 10, 2004
    Inventors: Rene Devos, Brian William Dymock, Christopher John Hobbs, Wen-Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera, Nobuo Shimma, Takuo Tsukuda
  • 4'-substituted nucleoside derivatives as inhibitors of HCV RNA replication
    Publication number: 20030236216
    Abstract: The present invention relates to the use of nucleoside derivatives of formula I 1
    Type: Application
    Filed: June 11, 2002
    Publication date: December 25, 2003
    Inventors: Rene Robert Devos, Christopher John Hobbs, Wen Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera, Nobuo Shimma, Takuo Tsukuda
  • Method for identifying an enzyme to design anti-cancer compounds
    Publication number: 20030138864
    Abstract: The present invention relates to a method for identification of enzymes that are preferentially expressed in certain tumor tissue as compared with rapidly growing normal cells or tissue, use of said enzymes for the compound design to generate an active anti-cancer substance selectively in tumor tissue, compounds designed based on said enzymes, their pharmaceutically acceptable salts as well as pharmaceutical composition thereof.
    Type: Application
    Filed: November 21, 2002
    Publication date: July 24, 2003
    Inventors: Hideo Ishitsuka, Hisafumi Okabe, Nobuo Shimma, Takuo Tsukuda, Isao Umeda
  • Anti-HCV nucleoside derivatives
    Publication number: 20030008841
    Abstract: The present invention comprises novel and known purine and pyrimidine nucleoside derivatives which have been discovered to be active against hepatitis C virus (HCV). The use of these derivatives for the treatment of HCV infection is claimed as are the novel nucleoside derivatives disclosed herein.
    Type: Application
    Filed: August 7, 2001
    Publication date: January 9, 2003
    Inventors: Rene Devos, Brian William Dymock, Christopher John Hobbs, Wen-Rong Jiang, Joseph Armstrong Martin, John Herbert Merrett, Isabel Najera, Nobuo Shimma, Takuo Tsukuda
  • Azole derivatives
    Publication number: 20010047017
    Abstract: The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), 1
    Type: Application
    Filed: March 22, 2001
    Publication date: November 29, 2001
    Inventors: Susumu Komiyama, Nobuo Shimma, Takuo Tsukuda
  • Azole derivatives
    Patent number: 6319933
    Abstract: The present invention is directed to new 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the formula (I), and pharmaceutically acceptable salts thereof wherein Q, R, X, Y and Z are the same as defined in the claims and the description. 1-(1H-1,2,4-triazol-1-yl)butan-2-ol derivatives of the present invention have antifungal activity and are useful for the treatment of fungal diseases.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: November 20, 2001
    Assignee: Basilea Pharmaceutica AG
    Inventors: Susumu Komiyama, Nobuo Shimma, Takuo Tsukuda
  • Cyclohexane derivatives
    Patent number: 5719291
    Abstract: Compounds of the formula ##STR1## which have antifungal activity.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: February 17, 1998
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yuhko Aoki, Hiromichi Kotaki, Kazunao Masubuchi, Toru Okuda, Nobuo Shimma, Takuo Tsukuda, Isao Umeda
  • Cyclohexane derivatives
    Patent number: 5449785
    Abstract: Compounds of the formula ##STR1## which have antifungal activity.
    Type: Grant
    Filed: July 10, 1992
    Date of Patent: September 12, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Yuhko Aoki, Hiromichi Kotaki, Kazunao Masubuchi, Toru Okuda, Nobuo Shimma, Takuo Tsukuda, Isao Umeda