Patents by Inventor Takushi Yamamoto
Takushi Yamamoto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11545350Abstract: One mode is a method for the structural analysis of an organic compound by MALDI mass spectrometry, including: a sample preparation process (S1) which includes preparing a sample by mixing a specimen containing an organic compound to be analyzed with a predetermined matrix at a mixture ratio within a range from 1:5 to 1:5000 in molar ratio; a mass spectrometry process (S3) which includes irradiating the prepared sample with a laser beam having a spot size equal to or smaller than 15 ?m to generate ions originating from a component of the specimen in the sample, and performing a mass spectrometric analysis of the generated ions; and an analyzing process (S4) which includes detecting, from a mass spectrum acquired in the mass spectrometry process, ions including product ions resulting from in-source decay, and estimating the structure of the organic compound to be analyzed based on information concerning the ions.Type: GrantFiled: June 28, 2021Date of Patent: January 3, 2023Assignees: SHIMADZU CORPORATION, HIROSHIMA UNIVERSITYInventors: Koichi Tanaka, Takushi Yamamoto, Manaho Yamaguchi, Shunsuke Izumi
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Patent number: 11469087Abstract: Imaging mass spectrometry section (100) performs a mass spectrometric analysis at each of the micro areas set within a measurement area on a target sample, and acquires a graphical image showing a signal-intensity distribution at a specific mass-to-charge ratio or mass-to-charge-ratio range. Quantitative analysis section (300) determines a quantitative value using an analysis result obtained by performing an analysis on the sample collected from each predetermined site within the measurement area of the target sample, using a predetermined analytical technique exhibiting a higher level of quantitative determination performance than the mass spectrometric analysis.Type: GrantFiled: December 7, 2020Date of Patent: October 11, 2022Assignee: SHIMADZU CORPORATIONInventors: Shinichi Yamaguchi, Takushi Yamamoto
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Publication number: 20210358733Abstract: One mode is a method for the structural analysis of an organic compound by MALDI mass spectrometry, including: a sample preparation process (S1) which includes preparing a sample by mixing a specimen containing an organic compound to be analyzed with a predetermined matrix at a mixture ratio within a range from 1:5 to 1:5000 in molar ratio; a mass spectrometry process (S3) which includes irradiating the prepared sample with a laser beam having a spot size equal to or smaller than 15 ?m to generate ions originating from a component of the specimen in the sample, and performing a mass spectrometric analysis of the generated ions; and an analyzing process (S4) which includes detecting, from a mass spectrum acquired in the mass spectrometry process, ions including product ions resulting from in-source decay, and estimating the structure of the organic compound to be analyzed based on information concerning the ions.Type: ApplicationFiled: June 28, 2021Publication date: November 18, 2021Applicants: SHIMADZU CORPORATION, HIROSHIMA UNIVERSITYInventors: Koichi TANAKA, Takushi YAMAMOTO, Manaho YAMAGUCHI, Shunsuke IZUMI
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Publication number: 20210296104Abstract: Imaging mass spectrometry section (100) performs a mass spectrometric analysis at each of the micro areas set within a measurement area on a target sample, and acquires a graphical image showing a signal-intensity distribution at a specific mass-to-charge ratio or mass-to-charge-ratio range. Quantitative analysis section (300) determines a quantitative value using an analysis result obtained by performing an analysis on the sample collected from each predetermined site within the measurement area of the target sample, using a predetermined analytical technique exhibiting a higher level of quantitative determination performance than the mass spectrometric analysis.Type: ApplicationFiled: December 7, 2020Publication date: September 23, 2021Applicant: SHIMADZU CORPORATIONInventors: Shinichi Yamaguchi, Takushi Yamamoto
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Patent number: 11024493Abstract: An analyzing device includes: a measurement data acquisition unit that acquires measurement data obtained by irradiating a plurality of irradiation positions on a sample with a laser beam and performing mass spectrometry on a sample component corresponding to each irradiation position; and an analysis unit that performs analysis of the measurement data by excluding a set of data corresponding to an excluded irradiation position among the plurality of irradiation positions each having a different irradiation portion from which a portion that has been already irradiated with the laser beam is excluded in an irradiation range irradiated when the laser beam is irradiated to each irradiation position.Type: GrantFiled: September 20, 2019Date of Patent: June 1, 2021Assignee: SHIMADZU CORPORATIONInventors: Takushi Yamamoto, Eiichi Matsuo
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Publication number: 20200270467Abstract: A filler for a concrete structure is provided. The filler includes an organic-inorganic composite hydrogel (A). The organic-inorganic composite hydrogel (A) has a three-dimensional network structure that includes a polymer of a water-soluble organic monomer and includes a water-swellable clay mineral. The filler has a water pressure resistance of 0.2 MPa or greater. The filler for a concrete structure has excellent workability and various excellent physical properties in terms of, for example, adhesion to wet surfaces and resistance to water pressure. Accordingly, the filler is suitable for use as a filler for joints and cracks of concrete structural objects.Type: ApplicationFiled: September 18, 2018Publication date: August 27, 2020Inventors: Toru TAKEHISA, Takushi YAMAMOTO, Takashi MATSUMOTO
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Publication number: 20200211829Abstract: An imaging mass spectrometry device includes: an ionization unit that ionizes a sample at a plurality of positions on the sample; a mass spectrometry unit that performs mass spectrometry on the ionized sample and detects fragment ions generated by dissociation of a precursor ion derived from the sample; a data acquisition unit that acquires intensity data in which intensities of a fragment ion are correlated with the plurality of positions on the sample; an image creation unit that creates image data in which a value obtained by integrating the intensity data corresponding to a plurality of different fragment ions generated from the same precursor ion is expressed by a pixel value or a pixel color at positions on an image respectively corresponding to the plurality of positions; and a display unit that displays an image corresponding to the image data.Type: ApplicationFiled: October 23, 2019Publication date: July 2, 2020Applicant: SHIMADZU CORPORATIONInventors: Eiichi MATSUO, Takushi Yamamoto
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Publication number: 20200098553Abstract: An analyzing device includes: a measurement data acquisition unit that acquires measurement data obtained by irradiating a plurality of irradiation positions on a sample with a laser beam and performing mass spectrometry on a sample component corresponding to each irradiation position; and an analysis unit that performs analysis of the measurement data by excluding a set of data corresponding to an excluded irradiation position among the plurality of irradiation positions each having a different irradiation portion from which a portion that has been already irradiated with the laser beam is excluded in an irradiation range irradiated when the laser beam is irradiated to each irradiation position.Type: ApplicationFiled: September 20, 2019Publication date: March 26, 2020Applicant: Shimadzu CorporationInventors: Takushi Yamamoto, Eiichi Matsuo
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Publication number: 20170294297Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.Type: ApplicationFiled: June 23, 2017Publication date: October 12, 2017Applicants: SHIMADZU CORPORATIONInventors: Koretsugu OGATA, Kazuteru TAKAHASHI, Akiko KUBO, Makoto SUEMATSU, Takushi YAMAMOTO
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Patent number: 9721776Abstract: After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.Type: GrantFiled: April 4, 2014Date of Patent: August 1, 2017Assignees: SHIMADZU CORPORATION, KEIO UNIVERSITYInventors: Koretsugu Ogata, Kazuteru Takahashi, Akiko Kubo, Makoto Suematsu, Takushi Yamamoto
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Patent number: 5567744Abstract: The present invention is concerned with a high water-absorbent resin composition, produced by forming a composite by fusing or fixing a thermoplastic resin onto a surface of a high water-absorbent resin via an adhesive binder or directly, wherein the composition comprises from 1 to 100 parts by weight of the thermoplastic resin, based on 100 parts by weight of the high water-absorbent resin.When the high water-absorbent resin composition of the present invention is used, it is possible to securely adhere a high water-absorbent resin to a fibrous base material, so that a water-absorbent material which stably retains the high water-absorbent resin even after absorbing water can be obtained. Accordingly, the base materials, such as fibrous base materials, can retain more amount of high water-absorbent resin than those of conventional water-absorbent materials.Type: GrantFiled: November 17, 1994Date of Patent: October 22, 1996Assignees: Sumitomo Seika Chemicals Co., Ltd., Uni-Charm CorporationInventors: Manabu Nagata, Takushi Yamamoto, Shinichi Takemori, Naoyuki Hashimoto, Hiroki Ishikawa, Yozo Yamada
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Patent number: 5334679Abstract: The present invention is directed to a method for production of a water-soluble cationic polymer comprising polymerizing a cationic vinyl monomer; either a cationic acrylate monomer alone or a mixture of said monomer and another monomer copolymerizable therewith, in dispersion medium in the presence of a surfactant by suspension polymerization method. The present invention offers an industrially advantageous method to obtain the water-soluble cationic polymer with a high degree of cationization and a high viscosity in water solution which can be used for flocculants, antistatic agents, retention aids for paper manufacturing and other purposes.Type: GrantFiled: July 22, 1993Date of Patent: August 2, 1994Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Takushi Yamamoto, Hiroari Hara, Nobuhiro Maeda, Morio Nakamura
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Patent number: 5180798Abstract: An improved process for the production of a water-absorbent resin by reversed phase suspension polymerization of a water-soluble ethylenic unsaturated monomer is disclosed. The process is conducted by subjecting an aqueous solution of a water-soluble ethylenic unsaturated monomer to reversed phase suspension polymerization reaction of a first stage in a petroleum hydrocarbon solvent in the presence of a surfactant and/or polymeric protective colloid by using a radical polymerization initiator optionally in the presence of a crosslinking agent, cooling the resulting slurry to precipitate the surfactant and/or polymeric protective colloid, and adding an aqueous solution of a water-soluble ethylenic unsaturated monomer containing a radical polymerization initiator and optionally a crosslinking agent to the first polymerization reaction system to further carry out the reversed phase suspension polymerization reaction, at least, once.Type: GrantFiled: January 3, 1991Date of Patent: January 19, 1993Assignee: Sumitomo Seika Chemicals Co., Ltd.Inventors: Morio Nakamura, Takushi Yamamoto, Hitoshi Tanaka, Hitoshi Ozawa, Yasuhiro Shimada
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Patent number: 4972019Abstract: A water-absorbent resin composition having superior gel stability which comprises a water-absorbent resin, at least one oxygen-containing reducing inorganic salt and, optionally, at least one organic antioxidant.Type: GrantFiled: June 20, 1989Date of Patent: November 20, 1990Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Hitoshi Tanaka, Yuji Sakamoto
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Patent number: 4880888Abstract: A water-absorbent resin having excellent physical properties can be produced by a process wherein an aqueous solution containing an .alpha.,.beta.-unsaturated carboxylic acid and an alkali metal salt thereof in a total amount of 25% by weight or more is subjected to polymerization with a radical polymerization initiator in a petroleum-based hydrocarbon solvent in the presence or absence of a crosslinking agent, characterized by using, as a surfactant, a polyglycerine--fatty acid ester having an HLB of 2 to 16 and represented by the general formula ##STR1## (wherein R is an acyl group or hydrogen atom and n is an integer of 0 to 8).Type: GrantFiled: January 5, 1987Date of Patent: November 14, 1989Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Hitoshi Tanaka, Yuji Sakamoto
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Patent number: 4863989Abstract: A water-absorbent resin composition having superior gel stability which comprises a water-absorbent resin, at least one oxygen-containing reducing inorganic salt and, optionally, at least one organic antioxidant.Type: GrantFiled: May 26, 1987Date of Patent: September 5, 1989Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Hitoshi Tanaka, Yuji Sakamoto
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Patent number: 4732968Abstract: A water-absorbent resin having an appropriate particle size and a narrow particle size distribution can be obtained by adding a powdered inorganic material in a proportion of 0.000005-0.2 part by weight to 1 part by weight of a water-absorbent resin containing therein a carboxylate as a component of the polymer with agitation in an inert solvent in the presence of 0.1-5.0 parts by weight of water and 0.005-0.2 part by weight of a surfactant and then removing water and the inert solvent by distillation.Type: GrantFiled: December 3, 1986Date of Patent: March 22, 1988Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Hitoshi Tanaka, Yuji Sakamoto, Yasuhiro Shimada
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Patent number: 4683274Abstract: A water-absorbent resin usable as a suitable water absorbent in sanitary materials and other fields can be produced by subjecting an aqueous solution of an .alpha.,.beta.-unsaturated carboxylic acid and of an alkali metal salt thereof to polymerization with a radical polymerization initiator in a petroleum-based hydrocarbon solvent in the presence or absence of a crosslinking agent and, in this polymerization, using a saccharose-fatty acid ester as a protective colloid agent.Type: GrantFiled: May 28, 1985Date of Patent: July 28, 1987Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Morio Nakamura, Shigeji Obayashi, Takushi Yamamoto, Toshikazu Nakanishi, Hitoshi Tanaka, Yuji Sakamoto
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Patent number: 4541871Abstract: Water-absorbent resins having improved water-absorbency, water-absorption rate and water-dispersibility can be produced by crosslinking a water-absorbent resin comprising a carboxylate as a constituent of the resin with a crosslinking agent having at least two functional groups in the presence of water in a proportion of 0.01 to 1.3 parts by weight per part by weight of the resin in an inert solvent.Type: GrantFiled: August 7, 1984Date of Patent: September 17, 1985Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Masato Fujikake
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Patent number: 4507438Abstract: Water-absorbent resins having improved water-absorbency, water-absorption rate and water-dispersibility can be produced by crosslinking a water-absorbent resin comprising a carboxylate as a constituent of the resin with a crosslinking agent having at least two functional groups in the presence of water in a proportion of 0.01 to 1.3 parts by weight per part by weight of the resin in an inert solvent.Type: GrantFiled: December 9, 1982Date of Patent: March 26, 1985Assignee: Seitetsu Kagaku Co., Ltd.Inventors: Shigeji Obayashi, Morio Nakamura, Takushi Yamamoto, Masato Fujikake