Abstract: The invention relates to particles of a calcium salt of a fatty acid having 12 to 22 carbon atoms, wherein the median size is 4.0 ?m to 15.0 ?m, the particle size digest A expressed by the following equation (1) satisfies the relation A?2.0, and the average thickness is 350 to 800 nm. Particle size digest A=(D90?D10)/D50??equation (1) (Here, 4.0?D50?15.0.

Abstract: Provided is an elastomer that improves the skin feel of an inorganic powder. The elastomer according to the present invention is an elastomeric mixture comprising an amino group-containing silicone polymer and a carboxyl group-containing silicone polymer or a carboxyl group-containing acrylamide polymer. The molar ratio of amino groups to carboxyl groups in the mixture is within the range of 0.1 to 1.2.

Abstract: Provided is an elastomer that improves the skin feel of an inorganic powder. The elastomer according to the present invention is an elastomer comprising: (A) an amino group-containing silicone polymer; and (B) a carboxyl group-containing silicone polymer or a carboxyl group-containing acrylamide polymer, wherein a molar ratio Y/X between amino groups and carboxyl groups is within a range of 0.1 to 1.2, wherein Y denotes the molar amount of carboxyl groups contained in the component (B), and X denotes the molar amount of amino groups contained in the component (A).

Abstract: Provided is an elastomer that improves the skin feel of an inorganic powder. The elastomer according to the present invention is an elastomer comprising: (A) an amino group-containing silicone polymer; and (B) a carboxyl group-containing silicone polymer or a carboxyl group-containing acrylamide polymer, wherein a molar ratio Y/X between amino groups and carboxyl groups is within a range of 0.1 to 1.2, wherein Y denotes the molar amount of carboxyl groups contained in the component (B), and X denotes the molar amount of amino groups contained in the component (A).

Abstract: A sunscreen cosmetic eliminates instability of a dibenzoylmethane derivative that is a UVA absorbing-agent, which exhibits excellent ultraviolet radiation protection performance across a wide wavelength region from UVA to UVB, and which exhibits excellent light resistance, is stable over time, and does not suffer from discoloration or crystal precipitation, and with which unnatural whiteness does not occur. A sunscreen cosmetic contains (a) a dibenzoylmethane derivative and (b) a powder that is surface-hydrophobized by means of treatment with a metal soap comprising a higher fatty acid and an alkaline earth metal or a combined treatment involving the use of a higher fatty acid and an alkaline earth metal hydroxide. The alkaline earth metal is preferably calcium or magnesium, and the higher fatty acid is preferably isostearic acid.

Abstract: An oil-enclosed powdery composition includes an oil-enclosable powder; further comprising; a platy powder, aluminum hydroxide coating the platy powder, having a surface of a specific surface area of at least 10 m2/g, and a fluorine compound coating the aluminum hydroxide; and an oil droplet having at least 50% by mass of hydrocarbon oil based on a total oil component and at least 2.0×10?2 N/m of a surface tension value as a total oil component; wherein the oil-enclosable powder encompassing the oil droplet is like powder having an average particle size of 10 to 150 ?m and the oil-enclosed powdery composition is liquefiable by inunction.

Abstract: Wrinkles are improved by applying an oral preparation, injection preparation or external skin preparation having a substance that controls heparanase as an active ingredient thereof.

Abstract: The present invention aims to provide a UV protective cosmetic composition having a high SPF and having a protective effect in a broad wavelength region over UVA and UVB, without undesirable white appearance upon application to the skin. The UV protective cosmetic composition of the present invention comprises (a) 3-15% by mass of one or more UV absorbing agents; (b) 10-22% by mass of zinc oxide with an average particle diameter of 35-80 nm; and optionally (c) 0-0.5% by mass of a white pigment, wherein the SPF of the cosmetic is 30 or greater, and the critical wavelength of the cosmetic is 370 nm or greater.

Abstract: The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a ?-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

Abstract: The present invention provides an oil-in-water external skin preparation that has an excellent stability, excellent rough-surface correction effect, and excellent texture. The oil-in-water external skin preparation of the present invention is characterized by comprising (a) an aqueous phase containing resin particles obtained from 100 parts by weight of a vinyl-type monomer and 0.1 to 20 parts by weight of a monomer represented by the below general formula (I), (b) an oil phase, and (c) a surfactant comprising one or more selected from polyoxyethylene hydrogenated castor oil, silicone-type surfactants, and sulfonic acid-type surfactants, in the amount of 0.01 to 5% by mass of the total amount of the external skin preparation and 30% by mass or more of the total amount of surfactants. (In the above formula, R represents a hydrogen atom or a methyl group, 1 represents 1 to 50, and m represents 1 to 50.

Abstract: The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a ?-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

Abstract: A SCCA-1 production inhibitor, comprising as an active ingredient, at least one carboxamide derivative selected from the group consisting of compounds represented by the following formula (I): wherein X is CR5 or N, R1, R4 and R5 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, R2 and R3 each independently represent hydrogen, C1-C4 alkyl or a C1-C6 hydroxyalkyl group having 1-5 hydroxy groups, or each represents a group —(CH2)n—, wherein n represents an integer of 1 or 2, and may form a 5- to 6-membered ring together with the atoms to which they are bonded and with the carbonyl group, allantoin, and salts thereof.

Abstract: The present invention is benzilidene malonamide represented by the following formula (1) and salts thereof, an ultraviolet absorbent consisting of said new compound, and an external preparation containing this ultraviolet absorbent. The object of the present invention is to provide a new ultraviolet absorbent that is highly soluble in water, has superior absorption capacity over a wide ultraviolet wavelength range, has no absorption in the visible region, and is also highly stable and safe.

Abstract: The present invention is benzilidene malonamide represented by the following formula (1) and salts thereof, an ultraviolet absorbent consisting of said new compound, and an external preparation containing this ultraviolet absorbent. The object of the present invention is to provide a new ultraviolet absorbent that is highly soluble in water, has superior absorption capacity over a wide ultraviolet wavelength range, has no absorption in the visible region, and is also highly stable and safe.

Abstract: Disclosed is an ADAM inhibitor which enables to prevent or improve conditions caused by increase in ADAM activity. Specifically disclosed is an ascorbic acid derivative represented by the general formula (1) below or a salt thereof. [chemical formula 1] (1), wherein R represents a linear or branched alkyl group having 1 to 22 carbon atoms.

Abstract: Disclosed is an anti-wrinkle agent for ameliorating a wrinkle (particularly a fine wrinkle) developed when the barrier function is decreased by dryness and the like. Also disclosed is an ADAM inhibitor. The anti-wrinkle agent or the ADAM inhibitor comprises an alkyl glucoside represented by the general formula: (1) [wherein R represents a linear or branched alkyl group having 1 to 18 carbon atoms] or a salt thereof.

Abstract: A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions.

Abstract: An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions. wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl or SO2R2 (wherein R1 and R2 each are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; and is a single bond or a double bond.

Abstract: An azabicyclo compound (I) or a salt thereof in accordance with the present invention has an excellent inhibiting action on matrix metalloproteases (MMPs) activity, and is useful for pharmaceutical, cosmetic and skin external compositions. wherein R is H, alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, acyl, COOR1, carbamoyl or SO2R2 (wherein R1 and R2 each are alkyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl); X is methylene, ethylene or propylene; and is a single bond or a double bond.

Abstract: A dithiazole compound or a salt thereof expressed by formula (I): 1