Abstract: The present invention provides an efficient process for preparing a nucleic acid oligomer, in particular, a process for deprotecting efficiently a protecting group of hydroxy group of a ribose in a nucleic acid oligomer. Specifically, the present invention also provides a process for preparing a nucleic acid oligomer represented by formula (4), which comprises contacting a nucleic acid oligomer represented by formula (3) with a fluoride ion under an atmosphere of an inert gas or inert gases containing 15% or less of oxygen concentration (wherein the definitions of each groups described in formula (3) and formula (4) are the same as defined in the Description).

Abstract: The present invention provides an efficient process for preparing a nucleic acid oligomer, specifically a method for deprotecting a protecting group of hydroxy group in the nucleic acid oligomer effectively. The present invention provides also a process for preparing a nucleic acid oligomer represented by formula (4) which comprises contacting a nucleic acid oligomer represented by formula (3) with a fluoride ion under an atmosphere of an inert gas or inert gases containing 15% or less of oxygen concentration (wherein each definition of the groups described in the formula (3) and the formula (4) are the same as those described in the Description).

Abstract: The present invention provides an efficient process for preparing a nucleic acid oligomer, that is, a process for preparing a nucleic acid having a phosphate triester bond effectively by oxidizing a nucleic acid precursor having a phosphite triester bond. Also the present invention provides a process for preparing a nucleic acid compound having at its 5?-terminus a nucleotide represented by formula (I) by a phosphoramidite method, which comprises a step of reacting a precursor having a phosphite triester bond represented by a formula (II) (the definitions of substituents of formulae (I) and (II) are described in the Description) with an oxidation solution which contains iodine, pyridine and water, and a molar ratio of iodic acid to iodine (mole of iodic acid/mole of iodine) is 30×10?3 or less.

Abstract: The present invention provides an efficient process for preparing a nucleic acid oligomer, that is, a process for preparing a nucleic acid having a phosphate triester bond effectively by oxidizing a nucleic acid precursor having a phosphite triester bond. Specifically, the present invention provides a process for preparing a nucleic acid compound having at its 5?-terminus a nucleotide represented by formula (I) by a phosphoramidite method, which comprises a step of reacting a precursor having a phosphite triester bond represented by a formula (II) (the definitions of substituents of formulae (I) and (II) are described in the Description) with an oxidation solution subjected to a heat-treatment that contains iodine, pyridine and water.

Abstract: The present invention provides a method for preparing RNA by a phosphoramidite solid-phase synthesis using an porous inorganic carrier containing a primary amino group, the method being able to bring about an increased purity even in the synthesis of medium-stranded to long-stranded RNA. In the method for producing RNA, an amount of the primary amino group contained in the porous inorganic carrier satisfies the following formula (1): 0.7?(I×R)/S?1.8 [wherein, I is an amount of the amino group per unit mass of the porous inorganic carrier (?mol/g), as measured by a 2-nitrobenzenesulfonic acid adsorption method; R is a ratio of the primary amino group in the total amino groups contained in the porous inorganic carrier (amount of primary amino group/amount of total amino groups); and S is a specific surface area (m2/g) of the porous inorganic carrier as measured by a nitrogen adsorption method].

Abstract: According to one embodiment, a detection device is disclosed. The detection device includes a first region, a first electrode on the first region, a second region, a second electrode on the second region, a partition partitioning the first region and the second region and including a through hole, thereby communicating the first region with the second region. The device further includes a probe which binds specifically to the detection target, and is detachably connected to the first electrode, a detacher to detach the probe from the first electrode, a determination unit to determine whether the first liquid contains a detection target based on a change of electrical condition between the first electrode and the second electrode in a state where the first region and the second region are supplied with the first liquid and the second liquid, respectively.

Abstract: A containment vessel for containing a reactor pressure vessel, a reactor core, and a steam generator of a pressurized water reactor includes a main body equipped with a polar crane, a diaphragm set above the polar crane that partitions the main body, before and after a loss-of-coolant accident (LOCA), into an upper vessel including a dome part having an open space and a lower vessel isolated from the upper vessel, a pressure suppression chamber including a suppression pool that stores water and a gas phase in communication with the open space, a LOCA vent pipe connecting the suppression pool to the lower vessel, and a vacuum breaker that equalizes pressure by allowing gas flow from the upper to the lower vessel when a pressure difference between the upper and lower vessels exceeds a preset value. The lower vessel contains all equipment and piping constituting a reactor pressure boundary.

Abstract: A glove compartment device having a lock body being mounted directly on a lid and a latch urging spring provided between a pivoting latch and the lock body with a spring force urging the pivoting latch to the side where engagement with a striker is released. A plate spring that is mounted on the lock body so as to urge the striker to the side to disengage from the pivoting latch when the plate spring has one end thereof engaged with the lock body before mounting of the plate spring onto the lock body is completed. A latch urging spring is a torsion spring and has one end engaged with the lock body opposing the plate spring from the side that prevents disengagement of the one end of the plate spring from the lock body.

Abstract: In a cylinder lock, a half tumbler biased to engage an engagement portion with a locking recess of a cylinder body is inserted into a tumbler insertion hole of a rotor so that the engagement portion is retraced from the locking recess in response to insertion of a legitimate mechanical key into a key insertion hole. An inner side surface of the tumbler insertion hole is formed to include: a guide portion facing a half tumbler and extending in a moving direction of the half tumbler; and a passage forming portion having larger clearance with the half tumbler than that of the guide portion to form a release passage between the passage forming portion and the half tumbler such that the release passage faces the key insertion hole, extends in the moving direction of the half tumbler, and has opposite ends opened to an outer surface of the rotor.

Abstract: A game apparatus includes a first LCD and a second LCD. The first LCD and the second LCD are arranged in either side of a predetermined axis. A computer of the game apparatus respectively displays a first character image and a second character image on the first LCD and the second LCD, and further respectively displays a first message image and a second message image on the first LCD and the second LCD. Then, in response to a predetermined operation performed via a touch panel, etc., at least one of the first message image and the second message image respectively displayed on the first LCD and the second LCD is updated.

Abstract: In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.

Abstract: A glove compartment device having a lock body being mounted directly on a lid and of a latch urging spring provided between a pivoting latch and the lock body with a spring force urging the pivoting latch to the side where engagement with a striker is released. A plate spring that is mounted on the lock body urging so as to urge the striker to the side to disengage from the pivoting latch when the plate spring has one end thereof engaged with the lock body before mounting of the plate spring onto the lock body is completed.

Abstract: The present invention provides a positive pressure chamber for treating extremities, which is used for treating extremity swelling or edema, rehabilitation, prophylaxis for deep venous thrombosis, relieving extremity pain, improvement of extremity skin, and the like.

Abstract: A modularized prosthesis leg cover quickly covers a prosthesis leg and does not affect bending or stretching motion of a knee joint part of the prosthesis leg, thus preventing damage to the knee joint part of the prosthesis leg. Thus, the modularized prosthesis leg cover includes a thigh module, which can be mounted to a thigh socket of the prosthesis leg, a lower leg module, which can be fastened to a calf pipe of the prosthesis leg, and a patella module, which can be rotatably assembled with the lower leg module. The prosthesis leg cover, which is formed by assembling the modules, is covered with a skin module, which is made of a stretchable fiber. The respective modules are provided as prefabricated modules. A method of manufacturing the prosthesis leg cover is also provided.

Abstract: In a nuclear reactor building of a steel plate concrete structure that houses a pressure containment vessel formed with a plurality of penetration ports penetrating the pressure containment vessel on the periphery thereof and includes a biological shielding wall disposed outside the pressure containment vessel. The pressure containment vessel is vertically divided into a plurality of blocks so that each of the blocks has one or more pressure containment vessel penetration ports arranged on a same horizontal plane, and the reactor building including the biological shielding wall is divided into a plurality of modules by the horizontal plane.

Abstract: The present invention provides a positive pressure chamber for treating extremities, which is used for treating extremity swelling or edema, rehabilitation, prophylaxis for deep venous thrombosis, relieving extremity pain, improvement of extremity skin, and the like.

Abstract: A containment vessel for containing a reactor pressure vessel and steam generators has a main containment vessel, a diaphragm, a pressure suppression chamber, LOCA vent pipes. The reactor pressure vessel contains a reactor core of a pressurized water reactor. The diaphragm partitions the main containment vessel into an upper vessel and a lower vessel. The pressure suppression chamber has a suppression pool to store water and gas phase of the pressure suppression chamber communicates with the upper vessel. The LOCA vent pipes connect the pressure suppression chamber to the lower vessel. All of the equipments and piping that constitute the reactor pressure boundary, including the reactor pressure vessel, the steam generators, a cold leg pipe and a hot leg pipe, are contained in the lower vessel.

Abstract: In a glove box device, a cylinder is fixed to an operating handle, a slide member switches between a locking state and an unlocking state in correspondence to sliding motion, and a connecting member is interposed between one end of the slide member and a rotor. The connecting member transmits a turning force of the rotor turning along with the operating handle to the slide member, to move the slide member from a locking position to an unlocking position when the rotor is in the unlocking position. The connecting member cuts off the transmission of turning force between the slide member in the locking position and the rotor, when the rotor is in the locking position. Thus, it is possible to reduce the number of components needed, and also to reduce a gap between a design face of the operating handle and the cylinder lock, thereby improving the appearance.

Abstract: A reactor feedwater system of a boiling water reactor includes: a reactor feedwater pump and a high pressure feedwater heater, that are arranged at an outside of a reactor containment vessel containing a reactor pressure vessel of a boiling water reactor, for pressurizing and heating a coolant; a main feedwater pipe for supplying the coolant, that are pressurized and heated by the reactor feedwater pump and the high pressure feedwater heater, to a side of the reactor containment vessel; and a plurality of branch pipes, that are connected to the main feedwater pipe, for pouring the coolant into the reactor pressure vessel. The main feedwater pipe is provided to the outside of the reactor containment vessel, and branching positions at which the branch pipes are branched from the main feedwater pipe are set to the outside of the reactor containment vessel, so that only the branch pipes penetrate through the reactor containment vessel and are connected to the reactor pressure vessel.

Abstract: A game apparatus includes a first LCD and a second LCD. The first LCD and the second LCD are arranged in either side of a predetermined axis. A computer of the game apparatus respectively displays a first character image and a second character image on the first LCD and the second LCD, and further respectively displays a first message image and a second message image on the first LCD and the second LCD. Then, in response to a predetermined operation performed via a touch panel, etc., at least one of the first message image and the second message image respectively displayed on the first LCD and the second LCD is updated.