Abstract: A coupling member is provided that includes a filtration member provided in a fluid passage in a coupling body to divide the fluid passage into an upstream pre-filtration passage section and a downstream post-filtration passage section. The filtration member includes a cylindrical part extending in the direction of a longitudinal axis and having a filtration portion. The cylindrical part divides a downstream portion of the pre-filtration passage section and an upstream portion of the post-filtration passage section from each other in the radial direction of the cylindrical part. Further, the fluid passage has a dust collecting part extending in the direction of the longitudinal axis from the downstream portion to a position closer to a downstream opening than the filtration portion of the filtration member. The dust collecting part is closed at a downstream end thereof.

Abstract: A check valve is provided which comprises a casing having a fluid passage, a valve seat member disposed in the fluid passage, and a valve element housing with a valve element disposed therein. The valve seat member has a valve seat surface on an end surface facing downstream. The valve element housing is a discrete member separate from the valve seat member and detachably secured to a downstream end portion of the same. The valve element is displaceable between a closed position and an open position.

Abstract: In order to reduce a pressure loss in a check valve and simplify a manufacturing process, a check valve (10) configured to be disposed in piping of fluid is provided, which includes a valve housing (31) including a valve element (52) and a valve seat (54) therein, a casing (20) that is configured to place the valve housing therein, in which a casing flow path (60) is provided between the casing and the valve housing to make a flow of the fluid in an axial direction of the valve housing. In the valve housing, a communicating hole (38) and sealing portion (34) are formed. The communicating hole that is formed through the valve housing in a thickness direction thereof introduces the fluid, which flows through between the valve element and the valve seat at the open position of the check valve, into the casing flow path.

Abstract: Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): wherein all symbols represent the same meanings as those described in the description, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.

Abstract: Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): wherein all symbols represent the same meanings as those described in the description, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.

Abstract: A steel sheet suitable as a starting material for a vehicle impact absorbing member with high absorption of impact energy and resistance to cracking contains, by mass %, C: 0.08-0.30%, Mn: 1.5-3.5%; Si+Al: 0.50-3.0%, P: 0.10% or less, S: at most 0.010%, and N: at most 0.010%, and optionally, one or more types selected from Cr: at most 0.5%, Mo: at most 0.5% , B: at most 0.010%, Ti: less than 0.04%, Nb: less than 0.030%, V: less than 0.5%, Ca: at most 0.010%, Mg: at most 0.010%, REM: at most 0.050%, and Bi: at most 0.050%. The microstructure contains, by area %, bainite: more than 50%, martensite: 3-30%, and retained austenite: 3-15%, the remainder comprising ferrite having an average grain diameter of less than 5 mm. The product of uniform elongation and hole expansion ratio is at least 300%2 and 5% effective flow stress is at least 900 MPa.

Abstract: Provided is a check valve element enabling efficient supply of fluid while suppressing the occurrence of chattering. The check valve element is provided to be displaceable upstream and downstream in a downstream flow path extending downstream from a valve seat having an opening for introducing a fluid and is pressed against the valve seat by a pre-closing urging force applied thereto toward an upstream side.

Abstract: Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): wherein all symbols represent the same meanings as those described in the description, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.

Abstract: The present invention provides a somatostatin receptor subtype 2 agonist. A disclosed compound represented by the general formula (I): wherein all symbols have the same definitions as described in the specification; a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug of the foregoing is a low-molecular compound having strong somatostatin receptor subtype 2 agonistic activity, and thus can be administered in a simple manner, has high stability and has low toxicity. Therefore, the present compound is useful for prophylaxis and/or therapy of somatostatin-related diseases such as acromegaly and gastrointestinal obstruction.

Abstract: A hot-rolled steel sheet having a composition comprising, in mass %, C: 0.06 to 0.3%, Si: 0.4 to 2.5%, Mn: 0.6 to 3.5%, P: at most 0.1%, S: at most 0.05%, Ti: 0 to 0.08%, Nb: 0 to 0.04%, a total content of Ti and Nb: 0 to 0.10%, sol.Al: 0 to 2.0%, Cr: 0 to 1%, Mo: 0 to 0.3%, V: 0 to 0.3%, B: 0 to 0.005%, Ca: 0 to 0.003%, REM: 0 to 0.003%, the remainder Fe and impurities, is cold rolled, then heated at an average heating rate of at least 15° C./sec so that a proportion of an unrecrystallization of a region not transformed to austenite at a time of reaching (Ac1 point+10° C.) is at least 30 area %, and then held for 30 seconds at temperature of at least (0.9×Ac1 point+0.1×Ac3 point) and at most (Ac3 point+100° C.).

Abstract: Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): [wherein all symbols represent the same meanings as those described in the description] a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.

Abstract: A high-strength cold-rolled steel sheet includes a composition having controlled amounts of carbon, silicon, manganese, phosphorous, sulfur, titanium, niobium, sol. Aluminum, chromium, molybdenum, vanadium, boron, calcium, REM, and iron. A microstructure thereof has a main phase of ferrite of at least 40 area %, and a second phase of a low-temperature transformation phase consisting either or both of martensite and bainite, which comprises at least 10 area % in total and retained austenite (?) at least comprising 3 area % . An average grain diameter of ferrite has a tilt angle of at least 15° is at most 5.0 mm, an average grain diameter of the low-temperature transformation-produced phase is at most 2.0 mm, an average grain diameter of lump-like retained ? having an aspect ratio of less than 5 is at most 1.5 mm, and an area fraction of the lump-like retained ? relative to the retained ? is at least 50%.

Abstract: A high-strength cold-rolled steel sheet excellent in ductility, work hardenability, and stretch flangeability, and having tensile strength of 780 MPa or more includes: a chemical composition containing, in mass percent, C: more than 0.020% to less than 0.30%, Si: more than 0.10% to 3.00% or less, Mn: more than 1.00% to 3.50% or less; and metallurgical structure whose main phase is a low-temperature transformation product, and whose secondary phase contains retained austenite. The retained austenite has a volume fraction relative to overall structure of more than 4.0% to less than 25.0% and an average grain size of less than 0.80 ?m, and of the retained austenite, the number density of retained austenite grains whose grain size is 1.2 ?m or more is 3.0×10?2 grains/?m2 or less.

Abstract: The present invention provides a somatostatin receptor subtype 2 agonist. A disclosed compound represented by the general formula (I): wherein all symbols have the same definitions as described in the specification; a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug of the foregoing is a low-molecular compound having strong somatostatin receptor subtype 2 agonistic activity, and thus can be administered in a simple manner, has high stability and has low toxicity. Therefore, the present compound is useful for prophylaxis and/or therapy of somatostatin-related diseases such as acromegaly and gastrointestinal obstruction.

Abstract: In order to reduce a pressure loss in a check valve and simplify a manufacturing process, a check valve (10) configured to be disposed in piping of fluid is provided, which includes a valve housing (31) including a valve element (52) and a valve seat (54) therein, a casing (20) that is configured to place the valve housing therein, in which a casing flow path (60) is provided between the casing and the valve housing to make a flow of the fluid in an axial direction of the valve housing. In the valve housing, a communicating hole (38) and sealing portion (34) are formed. The communicating hole that is formed through the valve housing in a thickness direction thereof introduces the fluid, which flows through between the valve element and the valve seat at the open position of the check valve, into the casing flow path.

Abstract: Provided is a check valve element enabling efficient supply of fluid while suppressing the occurrence of chattering. The check valve element is provided to be displaceable upstream and downstream in a downstream flow path extending downstream from a valve seat having an opening for introducing a fluid and is pressed against the valve seat by a pre-closing urging force applied thereto toward an upstream side.

Abstract: Provision of orally-available and low-toxic somatostatin receptor subtype 2 agonist. Since the compound represented by the general formula (I): [wherein all symbols represent the same meanings as those described in the description] a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof is non-peptidic low-molecular compound which has strong somatostatin receptor subtype 2 agonist activity, the compound is orally-available. Additionally, since the compound is low-toxic, the compound is useful for the prevention and/or treatment of the somatostatin related diseases such as acromegaly or gastrointestinal obstruction.

Abstract: A steel sheet suitable as a starting material for a vehicle impact absorbing member with high absorption of impact energy and resistance to cracking contains, by mass %, C: 0.08-0.30%, Mn: 1.5-3.5%; Si+Al: 0.50-3.0%, P: 0.10% or less, S: at most 0.010%, and N: at most 0.010%, and optionally, one or more types selected from Cr: at most 0.5%, Mo: at most 0.5%, B: at most 0.010%, Ti: less than 0.04%, Nb: less than 0.030%, V: less than 0.5%, Ca: at most 0.010%, Mg: at most 0.010%, REM: at most 0.050%, and Bi: at most 0.050%. The microstructure contains, by area %, bainite: more than 50%, martensite: 3-30%, and retained austenite: 3-15%, the remainder comprising ferrite having an average grain diameter of less than 5 mm. The product of uniform elongation and hole expansion ratio is at least 300%2 and 5% effective flow stress is at least 900 MPa.

Abstract: A high-strength cold-rolled steel sheet includes a composition having controlled amounts of carbon, silicon, manganese, phosphorous, sulfur, titanium, niobium, sol. Aluminum, chromium, molybdenum, vanadium, boron, calcium, REM, and iron. A microstructure thereof has a main phase of ferrite of at least 40 area %, and a second phase of a low-temperature transformation phase consisting either or both of martensite and bainite, which comprises at least 10 area % in total and retained austenite (?) at least comprising 3 area %. An average grain diameter of ferrite has a tilt angle of at least 15° is at most 5.0 mm, an average grain diameter of the low-temperature transformation-produced phase is at most 2.0 mm, an average grain diameter of lump-like retained ? having an aspect ratio of less than 5 is at most 1.5 mm, and an area fraction of the lump-like retained ? relative to the retained ? is at least 50%.

Abstract: A high-strength cold-rolled steel sheet having excellent ductility and stretch flangeability includes: a chemical composition consisting, in mass %, C: 0.06 to 0.3, Si: 0.6 to 2.5%, Mn: 0.6 to 3.5%, P: at most 0.1%, S: at most 0.05%, Ti: 0 to 0.08%, Nb: 0 to 0.04%, total of Ti and Nb: 0 to 0.10%, sol.Al: 0 to 2.0%, Cr: 0 to 1%, Mo: 0 to 0.3%, V: 0 to 0.3%, B: 0 to 0.005%, Ca: 0 to 0.003%, REM: 0 to 0.003% and the remainder of Fe and impurities; a microstructure having a main phase including at least 40 area % in total of martensite and/or bainite; and a texture in which proportion of an average X-ray intensity in an {100}<011> to {211}<011> orientations relative to an average X-ray intensity of a random structure not having a texture is less than 6.