Abstract: The present invention provides a method for producing an antigen-specific B cell population comprising IgG-positive B cells specific to a specific antigen, the method comprising: culturing IgG-positive B cells together with the specific antigen in the presence of IL-21, while conferring stimulation to the IgG-positive B cells via CD40, a BAFF receptor and Fas; and screening for antigen-specific B cells specific to the specific antigen to obtain an antigen-specific B cell population comprising the IgG-positive B cells specific to the specific antigen.

Abstract: The present invention provides a method for producing an antigen-specific B cell population comprising IgG-positive B cells specific to a specific antigen, the method comprising: culturing IgG-positive B cells together with the specific antigen in the presence of IL-21, while conferring stimulation to the IgG-positive B cells via CD40, a BAFF receptor and Fas; and screening for antigen-specific B cells specific to the specific antigen to obtain an antigen-specific B cell population comprising the IgG-positive B cells specific to the specific antigen.

Abstract: A housing holder is provided with detectors to be inserted into communication grooves of a connector. The detectors are electrically connected through a lead wire to a test device. The test device is also connected to an adapter electrically connected to a rear end of a probe on each terminal. During a continuity test, incomplete insertion or dropout of a terminal, and a short circuit between terminals are detected by comparing a circuitry formed by a contact of each terminal with the detector and probe with a circuitry stored in the memory of the test device beforehand.

Abstract: The present invention provides a smart tool for real-time measurement of a changing environment and real-time display of such information to the user, thereby supporting the user for example in surgery. Visual information in the vicinity of the tool tip is displayed to the user of the tool as haptic information. The smart tool comprises a tool (surgical knife), a light-receiving element for receiving the light reflected by an object in the vicinity of the tool tip, a decision portion for deciding the brightness and/or color of the object in the vicinity of the tool tip based on the output from said light-receiving element, a repulsive force calculation portion for calculating the repulsive force to be applied to said tool based on the output from said decision portion, a motor driving circuit for applying repulsive force to said tool based on the output from the repulsive force calculation portion, a motor, and a wire.