Abstract: An object of the present invention is to provide methods of discovering drugs effective for tough targets, which have conventionally been discovered only with difficulty. The present invention relates to novel methods for cyclizing peptide compounds, and novel peptide compounds and libraries comprising the same, to achieve the above object.

Abstract: The present invention provides a motion capture with a high accuracy which can replace an optical motion capture technology, without attaching optical markers and sensors to a subject. A subject with an articulated structure has a plurality of feature points in the body of the subject including a plurality of joints wherein a distance between adjacent feature points is obtained as a constant. A spatial distribution of a likelihood of a position of each feature point is obtained based on a single input image or a plurality of input images taken at the same time. One or a plurality of position candidates corresponding to each feature point are obtained based on the spatial distribution of the likelihood of the position of each feature point. Each join angle is obtained by performing an optimization calculation based on inverse kinematics using the candidates and the articulated structure.

Abstract: A switch device includes a case serving as a base portion and a knob attached to a fitting portion provided in the vicinity of an upper end of a cylindrical portion, in which the knob rotates in a seesaw-like manner around a rotary shaft member provided in the fitting portion, the knob includes an operation portion capable of being pulled up, the operation portion being provided on the front end side defined using the rotary shaft member as a boundary, and an abutment portion provided on the rear end side defined using the rotary shaft member as the boundary, the case includes a stopper portion configured to contact the abutment portion when the operation portion is pulled up, and the knob includes an extending portion extending toward the rear end side, the abutment portion being provided in the extending portion.

Abstract: A switch device which is capable of ensuring mounting strength of an additional member while ensuring ease of operation. The switch device has an operating knob that transmits an input operation to a switch unit with an electric contact, and a housing that houses a switch unit. The housing that houses the switch unit has an opening via which the switch unit and the operating knob face each other. The housing has a water prevention wall installed in a standing manner to surround the opening. The operating knob has a box-shaped base member with one end thereof opened. An additional member with at least one insertion portion which is inserted into a through hole of the base member is mounted on the base member. The insertion portion extends to cross a standing direction of the water prevention wall, and as seen in the standing direction, the insertion portion and the opening are located away from each other.

Abstract: A switch device which is capable of ensuring mounting strength of an additional member while ensuring ease of operation. The switch device has an operating knob that transmits an input operation to a switch unit with an electric contact, and a housing that houses a switch unit. The housing that houses the switch unit has an opening via which the switch unit and the operating knob face each other. The housing has a water prevention wall installed in a standing manner to surround the opening. The operating knob has a box-shaped base member with one end thereof opened. An additional member with at least one insertion portion which is inserted into a through hole of the base member is mounted on the base member. The insertion portion extends to cross a standing direction of the water prevention wall, and as seen in the standing direction, the insertion portion and the opening are located away from each other.