Patents by Inventor Takuya Washio
Takuya Washio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101532Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.Type: ApplicationFiled: November 28, 2023Publication date: March 28, 2024Inventors: Hideyuki Watanabe, Takashi Kamikubo, Akio Kamikawa, Takuya Washio, Yohei Seki, Keiichiro Okuyama, Osamu Ikeda, Hiroshi Tomiyama, Yoshinori Iwai, Akihiko Nakamura, Kozo Miyasaka
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Publication number: 20240043403Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.Type: ApplicationFiled: November 29, 2021Publication date: February 8, 2024Inventors: Hideyuki Watanabe, Takashi Kamikubo, Akio Kamikawa, Takuya Washio, Yohei Seki, Keiichiro Okuyama, Osamu Ikeda, Hiroshi Tomiyama, Yoshinori Iwai, Akihiko Nakamura, Kozo Miyasaka
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Patent number: 11085429Abstract: A compression device (1) includes compression portions, a suction line, connection lines, a discharge line, and display portions (d) configured to display pressure values, pressure gauges (PG1 to PG6) provided for at least one of the suction line, the connection lines, and the discharge line and a housing (40). The housing (40) includes a peripheral wall (42) and a door (44). The pressure gauges (PG1 to PG6) are situated at positions to face the door (44).Type: GrantFiled: May 31, 2019Date of Patent: August 10, 2021Assignee: Kobe Steel, Ltd.Inventors: Koichiro Hashimoto, Naofumi Kanei, Takuya Washio, Daisuke Wada, Ryosuke Mori
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Patent number: 11028839Abstract: The present application includes a compressor having a cylinder forming a compression chamber in which gas is compressed, a housing having a peripheral wall forming an internal space in which the compressor is stored, and a supporting member situated above the compressor in the internal space. The peripheral wall includes an opening wall in which a carry-out port is formed through which the cylinder is carried out. The supporting member extends to guide movement of a first lifting device between a position above the compressor and a position above the carry-out port. The cylinder is hung from the first lifting device.Type: GrantFiled: May 6, 2019Date of Patent: June 8, 2021Assignee: Kobe Steel, Ltd.Inventors: Koichiro Hashimoto, Kenji Nagura, Takuya Washio, Ryosuke Mori, Daisuke Wada
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Patent number: 11015589Abstract: A gas supplying apparatus includes a compressor, a housing having an exhaust port, and an exhaust duct. The housing has a circumferential wall and a top wall. The circumferential wall has an access section. The exhaust port is provided on at least one of the circumferential wall and the top wall at a location higher than the access section. The exhaust duct includes a discharge port for discharging the air, exhausted from the exhaust port, to the outside. The discharge port is opened upward or opened downward in an area overlapping the top wall in an up-and-down direction.Type: GrantFiled: October 16, 2018Date of Patent: May 25, 2021Assignee: Kobe Steel, Ltd.Inventors: Takuya Washio, Koichiro Hashimoto, Daisuke Wada, Kenji Nagura, Akitoshi Fujisawa
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Patent number: 10928883Abstract: A system management device connected with a plurality of computation nodes includes a memory including a program instruction and a processor connected with the memory. The processor creates a list of computation nodes in which update of software is to be performed, in accordance with an input software update request, and detects a computation node in an idle state satisfying a condition for power saving, in accordance with an input power-saving operation request. When the computation node detected by the processor is on the list, the processor deactivates the detected computation node for power saving after the software thereof is updated.Type: GrantFiled: January 8, 2019Date of Patent: February 23, 2021Assignee: NEC CORPORATIONInventor: Takuya Washio
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Patent number: 10711946Abstract: A combustible gas supply unit includes a high pressure gas facility for handling combustible gas which is compressed and a housing provided with a high pressure gas handling area containing the high pressure gas facility. The housing has a portion that is disposed in a side close to a boundary between premises of a hydrogen station and an outer region of the premises and constitutes the high pressure gas handling area, the portion being substantially composed of a partitioning wall member that resists an impact of an explosion of combustible gas.Type: GrantFiled: July 26, 2018Date of Patent: July 14, 2020Assignee: Kobe Steel, Ltd.Inventors: Takayuki Fukuda, Kenji Nagura, Koichiro Hashimoto, Daisuke Wada, Takuya Washio
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Publication number: 20190376862Abstract: A compression device (1) includes compression portions, a suction line, connection lines, a discharge line, and display portions (d) configured to display pressure values, pressure gauges (PG1 to PG6) provided for at least one of the suction line, the connection lines, and the discharge line and a housing (40). The housing (40) includes a peripheral wall (42) and a door (44). The pressure gauges (PG1 to PG6) are situated at positions to face the door (44).Type: ApplicationFiled: May 31, 2019Publication date: December 12, 2019Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.)Inventors: Koichiro HASHIMOTO, Naofumi KANEI, Takuya WASHIO, Daisuke WADA, Ryosuke MORI
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Publication number: 20190353306Abstract: The present application includes a compressor having a cylinder forming a compression chamber in which gas is compressed, a housing having a peripheral wall forming an internal space in which the compressor is stored, and a supporting member situated above the compressor in the internal space. The peripheral wall includes an opening wall in which a carry-out port is formed through which the cylinder is carried out. The supporting member extends to guide movement of a first lifting device between a position above the compressor and a position above the carry-out port. The cylinder is hung from the first lifting device.Type: ApplicationFiled: May 6, 2019Publication date: November 21, 2019Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (KOBE STEEL, LTD.)Inventors: Koichiro HASHIMOTO, Kenji NAGURA, Takuya WASHIO, Ryosuke MORI, Daisuke WADA
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Publication number: 20190227621Abstract: A system management device connected with a plurality of computation nodes includes a memory including a program instruction and a processor connected with the memory. The processor creates a list of computation nodes in which update of software is to be performed, in accordance with an input software update request, and detects a computation node in an idle state satisfying a condition for power saving, in accordance with an input power-saving operation request. When the computation node detected by the processor is on the list, the processor deactivates the detected computation node for power saving after the software thereof is updated.Type: ApplicationFiled: January 8, 2019Publication date: July 25, 2019Applicant: NEC CorporationInventor: Takuya WASHIO
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Publication number: 20190128265Abstract: A gas supplying apparatus includes a compressor, a housing having an exhaust port, and an exhaust duct. The housing has a circumferential wall and a top wall. The circumferential wall has an access section. The exhaust port is provided on at least one of the circumferential wall and the top wall at a location higher than the access section. The exhaust duct includes a discharge port for discharging the air, exhausted from the exhaust port, to the outside. The discharge port is opened upward or opened downward in an area overlapping the top wall in an up-and-down direction.Type: ApplicationFiled: October 16, 2018Publication date: May 2, 2019Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (Kobe Steel, Ltd.)Inventors: Takuya WASHIO, Koichiro HASHIMOTO, Daisuke WADA, Kenji NAGURA, Akitoshi FUJISAWA
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Publication number: 20190032850Abstract: A combustible gas supply unit includes a high pressure gas facility for handling combustible gas which is compressed and a housing provided with a high pressure gas handling area containing the high pressure gas facility. The housing has a portion that is disposed in a side close to a boundary between premises of a hydrogen station and an outer region of the premises and constitutes the high pressure gas handling area, the portion being substantially composed of a partitioning wall member that resists an impact of an explosion of combustible gas.Type: ApplicationFiled: July 26, 2018Publication date: January 31, 2019Applicant: KABUSHIKI KAISHA KOBE SEIKO SHO (Kobe Steel, Ltd.)Inventors: Takayuki FUKUDA, Kenji NAGURA, Koichiro HASHIMOTO, Daisuke WADA, Takuya WASHIO
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Patent number: 8962612Abstract: To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT5A receptor regulating action, it was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.Type: GrantFiled: August 1, 2013Date of Patent: February 24, 2015Assignee: Astellas Pharma Inc.Inventors: Wataru Hamaguchi, Isao Kinoyama, Yohei Koganemaru, Takehiro Miyazaki, Osamu Kaneko, Ryuichi Sekioka, Takuya Washio
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Patent number: 8853242Abstract: [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z1, Z2, Z3, Z4 and Z5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT5A receptor modulating actions and excellent pharmacological actions based on the 5-HT5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.Type: GrantFiled: August 5, 2010Date of Patent: October 7, 2014Assignee: Astellas Pharma Inc.Inventors: Isao Kinoyama, Takehiro Miyazaki, Yohei Koganemaru, Takuya Washio, Wataru Hamaguchi
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Publication number: 20130317010Abstract: To provide an excellent agent for preventing or treating dementia and schizophrenia based on serotonin 5-HT5A receptor regulating action, it was found that a tetrahydroisoquinoline derivative characterized by a structure in which an acylguanidino group binds to a N atom of a tetrahydroisoquinoline ring or the like, and a cyclic group binds to an unsaturated ring has a potent 5-HT5A receptor regulating action and an excellent pharmacological action based on the regulating action and also discovered that the tetrahydroisoquinoline derivative is useful as an agent for treating or preventing dementia, schizophrenia, and the like, whereby the present invention has been completed.Type: ApplicationFiled: August 1, 2013Publication date: November 28, 2013Applicant: Astellas Pharma IncInventors: Wataru HAMAGUCHI, Isao KINOYAMA, Yohei KOGANEMARU, Takehiro MIYAZAKI, Osamu KANEKO, Ryuichi SEKIOKA, Takuya WASHIO
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Publication number: 20120142727Abstract: [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z1, Z2, Z3, Z4 and Z5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT5A receptor modulating actions and excellent pharmacological actions based on the 5-HT5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.Type: ApplicationFiled: August 5, 2010Publication date: June 7, 2012Inventors: Isao Kinoyama, Takehiro Miyazaki, Yohei Koganemaru, Takuya Washio, Wataru Hamaguchi
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Publication number: 20120041036Abstract: An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on serotonin 5-HT5A receptor modulating action. It was discovered that acylguanidine derivatives, in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent the 5-HT5A receptor modulating action and excellent pharmacological actions based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.Type: ApplicationFiled: February 8, 2010Publication date: February 16, 2012Inventors: Isao Kinoyama, Yohei Koganemaru, Takehiro Miyazaki, Takuya Washio
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Publication number: 20110306621Abstract: An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT5A receptor modulating action. It was confirmed that acylguanidine derivatives, which has the characteristic structure in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent 5-HT5A receptor modulating action and excellent pharmacological action based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.Type: ApplicationFiled: February 8, 2010Publication date: December 15, 2011Inventors: Isao Kinoyama, Takehiro Miyazaki, Yohei Koganemaru, Nobuyuki Shiraishi, Yuichiro Kawamoto, Takuya Washio