Patents by Inventor Tal Dvir

Tal Dvir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12514957
    Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
    Type: Grant
    Filed: November 17, 2019
    Date of Patent: January 6, 2026
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Dan Peer, Michal Shevach, Neta Soffer Tsur
  • Publication number: 20250367348
    Abstract: A method for reinforcing a cellularized retinal construct fabricated from (i) endothelial cells; (ii) retinal pigment epithelial cells and/or photoreceptors; and (iii) an extracellular matrix (ECM) hydrogel is disclosed. The method comprises contacting the construct with a biocompatible small-molecule reinforcing agent that is capable of chemically interacting with the ECM hydrogel under conditions that maintain viability of the cells, to thereby increase a compressive modulus of the ECM hydrogel by at least 10%.
    Type: Application
    Filed: August 19, 2025
    Publication date: December 4, 2025
    Applicants: Ramot at Tel-Aviv University Ltd., Ichilov Tech Ltd.
    Inventors: Tal DVIR, Yahel SHECHTER, Eric SILBERMAN, Aya BARZELAY WOLLMAN, Adiel BARAK
  • Publication number: 20250361480
    Abstract: A method for generating reinforced engineered cellularized construct, which utilizes a biocompatible small-molecule reinforcing agent that do not affect the viability of the cells, a reinforced engineered cellularized construct obtained thereby and used the engineered cellularized construct are provided.
    Type: Application
    Filed: August 8, 2025
    Publication date: November 27, 2025
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Eric SILBERMAN
  • Publication number: 20250290036
    Abstract: A composition is disclosed which comprises solubilized decellularized omentum. Uses thereof and methods of generating same are also disclosed.
    Type: Application
    Filed: May 29, 2025
    Publication date: September 18, 2025
    Applicants: MATRICELF LTD., RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Tamar HAREL ADAR, Tal DVIR, Alex SAAR, Shirly TZELIK, Ron GOLDNER, Tammy BEN MORDECHAI, Ilana GROSS CARMEL, Tal BEN NERIAH
  • Patent number: 12311075
    Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.
    Type: Grant
    Filed: January 3, 2022
    Date of Patent: May 27, 2025
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Assaf Shapira, Michal Shevach, Idan Gal
  • Publication number: 20250145942
    Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.
    Type: Application
    Filed: January 3, 2025
    Publication date: May 8, 2025
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Assaf SHAPIRA
  • Patent number: 12221621
    Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: February 11, 2025
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Assaf Shapira
  • Publication number: 20240316112
    Abstract: A composition is disclosed which comprises a plurality of fibrous particles fabricated from decellularized omentum, the fibrous particles being between 750 microns-3 mm in diameter, wherein the fibrous particles comprise a network of mature neurons. Uses thereof and methods of generating same are also disclosed.
    Type: Application
    Filed: May 27, 2024
    Publication date: September 26, 2024
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Reuven EDRI, Lior WERTHEIM
  • Publication number: 20220118156
    Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.
    Type: Application
    Filed: January 3, 2022
    Publication date: April 21, 2022
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Assaf SHAPIRA, Michal SHEVACH, Idan GAL
  • Patent number: 11213609
    Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: January 4, 2022
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Assaf Shapira, Michal Shevach, Idan Gal
  • Publication number: 20210207083
    Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.
    Type: Application
    Filed: June 4, 2019
    Publication date: July 8, 2021
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Assaf SHAPIRA
  • Patent number: 10987059
    Abstract: A device comprising a three-dimensional polymeric element and an electronic element integrated with the polymeric element is disclosed. The electronic element is made up of one or more electrode(s) each individually connectable to a measuring device and/or a controller, and each independently having a thin electrically-isolating layer deposited thereon such that the electrode is exposed to an environment surrounding the electrode at one or more pre-determined locations over the electrode. The device can include cells and/or tissue and/or a therapeutically active agent incorporated within the polymeric material. Processes of fabricating the device, systems for operating the device and methods utilizing same are also disclosed.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: April 27, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Yosi Shacham-Diamand, Ron Feiner, Leeya Engel
  • Patent number: 10973957
    Abstract: A composition of matter for tissue engineering is disclosed. The composition comprises a plurality of electrospun albumin fibers, wherein an outer surface of the composition comprises a pattern of ridges or indentations, wherein the ridges or indentations are wider than the diameter of a single electrospun albumin fiber of the plurality of electrospun albumin fibers.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: April 13, 2021
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal Dvir, Sharon Fleischer
  • Publication number: 20200101198
    Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
    Type: Application
    Filed: November 17, 2019
    Publication date: April 2, 2020
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
  • Publication number: 20190336651
    Abstract: A composition of matter for tissue engineering is disclosed. The composition comprises a plurality of electrospun albumin fibers, wherein an outer surface of the composition comprises a pattern of ridges or indentations, wherein the ridges or indentations are wider than the diameter of a single electrospun albumin fiber of the plurality of electrospun albumin fibers.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 7, 2019
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Sharon FLEISCHER
  • Patent number: 10369255
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: August 6, 2019
    Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, Children's Medical Center Corporation
    Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
  • Publication number: 20180361023
    Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.
    Type: Application
    Filed: December 15, 2016
    Publication date: December 20, 2018
    Inventors: Tal DVIR, Assaf SHAPIRA, Michal SHEVACH, Idan GAL
  • Publication number: 20180000990
    Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
    Type: Application
    Filed: September 13, 2017
    Publication date: January 4, 2018
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
  • Publication number: 20170072109
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
    Type: Application
    Filed: July 21, 2016
    Publication date: March 16, 2017
    Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
  • Patent number: 9457128
    Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: October 4, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane