Patents by Inventor Tal Dvir
Tal Dvir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220118156Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.Type: ApplicationFiled: January 3, 2022Publication date: April 21, 2022Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Assaf SHAPIRA, Michal SHEVACH, Idan GAL
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Patent number: 11213609Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.Type: GrantFiled: December 15, 2016Date of Patent: January 4, 2022Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Tal Dvir, Assaf Shapira, Michal Shevach, Idan Gal
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Publication number: 20210207083Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.Type: ApplicationFiled: June 4, 2019Publication date: July 8, 2021Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Assaf SHAPIRA
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Patent number: 10987059Abstract: A device comprising a three-dimensional polymeric element and an electronic element integrated with the polymeric element is disclosed. The electronic element is made up of one or more electrode(s) each individually connectable to a measuring device and/or a controller, and each independently having a thin electrically-isolating layer deposited thereon such that the electrode is exposed to an environment surrounding the electrode at one or more pre-determined locations over the electrode. The device can include cells and/or tissue and/or a therapeutically active agent incorporated within the polymeric material. Processes of fabricating the device, systems for operating the device and methods utilizing same are also disclosed.Type: GrantFiled: November 17, 2014Date of Patent: April 27, 2021Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Tal Dvir, Yosi Shacham-Diamand, Ron Feiner, Leeya Engel
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Patent number: 10973957Abstract: A composition of matter for tissue engineering is disclosed. The composition comprises a plurality of electrospun albumin fibers, wherein an outer surface of the composition comprises a pattern of ridges or indentations, wherein the ridges or indentations are wider than the diameter of a single electrospun albumin fiber of the plurality of electrospun albumin fibers.Type: GrantFiled: January 10, 2018Date of Patent: April 13, 2021Assignee: Ramot at Tel-Aviv University Ltd.Inventors: Tal Dvir, Sharon Fleischer
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Publication number: 20200101198Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.Type: ApplicationFiled: November 17, 2019Publication date: April 2, 2020Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
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Publication number: 20190336651Abstract: A composition of matter for tissue engineering is disclosed. The composition comprises a plurality of electrospun albumin fibers, wherein an outer surface of the composition comprises a pattern of ridges or indentations, wherein the ridges or indentations are wider than the diameter of a single electrospun albumin fiber of the plurality of electrospun albumin fibers.Type: ApplicationFiled: January 10, 2018Publication date: November 7, 2019Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Sharon FLEISCHER
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Patent number: 10369255Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: GrantFiled: July 21, 2016Date of Patent: August 6, 2019Assignees: President and Fellows of Harvard College, Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Publication number: 20180361023Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 ?M in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.Type: ApplicationFiled: December 15, 2016Publication date: December 20, 2018Inventors: Tal DVIR, Assaf SHAPIRA, Michal SHEVACH, Idan GAL
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Publication number: 20180000990Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.Type: ApplicationFiled: September 13, 2017Publication date: January 4, 2018Applicant: Ramot at Tel-Aviv University Ltd.Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
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Publication number: 20170072109Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: ApplicationFiled: July 21, 2016Publication date: March 16, 2017Inventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Patent number: 9457128Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: GrantFiled: September 4, 2013Date of Patent: October 4, 2016Assignee: President and Fellows of Harvard CollegeInventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Publication number: 20160270729Abstract: A device comprising a three-dimensional polymeric element and an electronic element integrated with the polymeric element is disclosed. The electronic element is made up of one or more electrode(s) each individually connectable to a measuring device and/or a controller, and each independently having a thin electrically-isolating layer deposited thereon such that the electrode is exposed to an environment surrounding the electrode at one or more pre-determined locations over the electrode. The device can include cells and/or tissue and/or a therapeutically active agent incorporated within the polymeric material. Processes of fabricating the device, systems for operating the device and methods utilizing same are also disclosed.Type: ApplicationFiled: November 17, 2014Publication date: September 22, 2016Inventors: Tal DVIR, Yosi SHACHAM-DIAMAND, Ron FEINER, Leeya ENGEL
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Publication number: 20160106886Abstract: Metal nanoparticle-coated scaffolds are provided for use in tissue engineering.Type: ApplicationFiled: May 20, 2014Publication date: April 21, 2016Inventors: Tal DVIR, Michal SHEVACH, Ben M. MAOZ
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Patent number: 9114009Abstract: Electrically conductive nanowires incorporated within scaffolds enhance tissue growth, bridge the electrically resistant pore walls and markedly improve electrical communication between adjacent cardiac cell bundles. Integration of conducting nanowires within 3D scaffolds should improve the therapeutic value of cardiac patches. Examples demonstrate efficacy of gold nanowires in alginate matrices seeded with cardiomyocytes.Type: GrantFiled: December 28, 2011Date of Patent: August 25, 2015Assignees: Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Tal Dvir, Daniel S. Kohane, Robert S. Langer, Brian Timko
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Publication number: 20150202348Abstract: Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.Type: ApplicationFiled: December 23, 2014Publication date: July 23, 2015Inventors: Tal DVIR, Dan PEER, Michal SHEVACH, Neta SOFFER TSUR
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Publication number: 20140074253Abstract: The present invention generally relates to nanoscale wires and tissue engineering. In various embodiments, cell scaffolds for growing cells or tissues can be formed that include nanoscale wires that can be connected to electronic circuits extending externally of the cell scaffold. The nanoscale wires may form an integral part of cells or tissues grown from the cell scaffold, and can even be determined or controlled, e.g., using various electronic circuits. This approach allows for the creation of fundamentally new types of functionalized cells and tissues, due to the high degree of electronic control offered by the nanoscale wires and electronic circuits. Accordingly, such cell scaffolds can be used to grow cells or tissues which can be determined and/or controlled at very high resolutions, due to the presence of the nanoscale wires, and such cell scaffolds will find use in a wide variety of novel applications, including applications in tissue engineering, prosthetics, pacemakers, implants, or the like.Type: ApplicationFiled: September 4, 2013Publication date: March 13, 2014Applicants: President and Fellows of Harvard College, Children's Medical Center Corporation, Massachusetts Institute of TechnologyInventors: Charles M. Lieber, Jia Liu, Bozhi Tian, Tal Dvir, Robert S. Langer, Daniel S. Kohane
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Publication number: 20130289687Abstract: Electrically conductive nanowires incorporated within scaffolds enhance tissue growth, bridge the electrically resistant pore walls and markedly improve electrical communication between adjacent cardiac cell bundles. Integration of conducting nanowires within 3D scaffolds should improve the therapeutic value of cardiac patches. Examples demonstrate efficacy of gold nanowires in alginate matrices seeded with cardiomyocytes.Type: ApplicationFiled: December 28, 2011Publication date: October 31, 2013Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, Children's Medical Center CorporationInventors: Tal Dvir, Daniel S. Kohane, Robert S. Langer, Brian Timko
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Publication number: 20130004522Abstract: The present invention relates, in part, to a novel and simple particulate system that targets and binds any tissue selectively upon light illumination. The particulate system can be used for targeted delivery of substances to predefined cells or tissues in an individual.Type: ApplicationFiled: September 30, 2010Publication date: January 3, 2013Inventors: Tal Dvir, Daniel S. Kohane, Matthew Ryan Banghart, Robert S. Langer
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Patent number: 7608447Abstract: Disclosed is a novel net member for supporting one or more cell constructs in the culture chamber of a bioreactor, which comprises an array of impermeable pyramidal elements protruding from the face thereof, wherein each of the corners of the base of each of said impermeable pyramidal elements comprises a circular opening. This net member provides for uniform and unobstructed flow of culture medium through 3D cell constructs in culture. Also disclosed are a bioreactor and bioreactor system incorporating said net member. The bioreactor and bioreactor system may be used in the bioproduction of therapeutic proteins and stem cell expansion.Type: GrantFiled: December 9, 2004Date of Patent: October 27, 2009Assignee: Ben Gurion University of the Negev Research and Development AuthorityInventors: Smadar Cohen, Tal Dvir, Michal Shachar