Patents by Inventor Tal NOY-PORAT

Tal NOY-PORAT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies directed to ricin toxin
    Patent number: 10233256
    Abstract: An isolated monoclonal antibody or any antigen-binding fragment thereof which binds to ricin toxin, an expression vector including the isolated nucleic acid molecule and a host cell transfected with said isolated nucleic acid molecule or with the expression vector, a pharmaceutical composition including as an active ingredient the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule or the immunoconjugate and a pharmaceutically acceptable carrier, excipient or diluent, and a method of prophylaxis, treatment or amelioration of ricin toxin poisoning including administering to a subject in need thereof a therapeutically effective amount of the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule, the immunoconjugate or the pharmaceutical composition.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: March 19, 2019
    Assignee: THE ISRAEL INSTITUTE OF BIOLOGICAL RESEARCH (IIBR)
    Inventors: Ohad Mazor, Ronit Rosenfeld, Arie Ordentlich, Tal Noy-Porat
  • Antibodies directed to ricin toxin
    Patent number: 10208108
    Abstract: The invention provides a pharmaceutical composition comprising as an active ingredient a combination of three isolated monoclonal antibodies or any antigen-binding fragment thereof which bind ricin toxin and neutralize its toxic effects, and a pharmaceutically acceptable carrier, excipient or diluent. The invention also provides a method of prophylaxis, treatment or amelioration of ricin toxin poisoning including administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: February 19, 2019
    Assignee: THE ISRAEL INSTITUTE OF BIOLOGICAL RESEARCH (IIBR)
    Inventors: Ohad Mazor, Ronit Rosenfeld, Arie Ordentlich, Tal Noy-Porat
  • Acetylcholinesterase-Fc domain fusion protein
    Patent number: 10106785
    Abstract: Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these polypeptide constructs and uses thereof as scavenging agents of organophosphate compounds are described.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: October 23, 2018
    Assignee: THE ISRAEL INSTITUTE OF BIOLOGICAL RESEARCH (IIBR)
    Inventors: Ohad Mazor, Ofer Cohen, Tal Noy-Porat
  • ANTIBODIES DIRECTED TO RICIN TOXIN
    Publication number: 20170174752
    Abstract: The invention provides a pharmaceutical composition comprising as an active ingredient a combination of three isolated monoclonal antibodies or any antigen-binding fragment thereof which bind ricin toxin and neutralize its toxic effects, and a pharmaceutically acceptable carrier, excipient or diluent. The invention also provides a method of prophylaxis, treatment or amelioration of ricin toxin poisoning including administering to a subject in need thereof a therapeutically effective amount of the pharmaceutical composition.
    Type: Application
    Filed: January 4, 2017
    Publication date: June 22, 2017
    Inventors: Ohad MAZOR, Ronit ROSENFELD, Arie ORDENTLICH, Tal NOY-PORAT
  • ACETYLCHOLINESTERASE-Fc DOMAIN FUSION PROTEIN
    Publication number: 20160289657
    Abstract: Fusion polypeptides are provided including modified human Acetylcholinesterase conjugated to the Fc region of an immunoglobulin. Methods of preparing these polypeptide constructs and uses thereof as scavenging agents of organophosphate compounds are described.
    Type: Application
    Filed: April 4, 2016
    Publication date: October 6, 2016
    Inventors: Ohad MAZOR, Ofer COHEN, Tal NOY-PORAT
  • ANTIBODIES DIRECTED TO RICIN TOXIN
    Publication number: 20160152732
    Abstract: An isolated monoclonal antibody or any antigen-binding fragment thereof which binds to ricin toxin, an expression vector including the isolated nucleic acid molecule and a host cell transfected with said isolated nucleic acid molecule or with the expression vector, a pharmaceutical composition including as an active ingredient the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule or the immunoconjugate and a pharmaceutically acceptable carrier, excipient or diluent, and a method of prophylaxis, treatment or amelioration of ricin toxin poisoning including administering to a subject in need thereof a therapeutically effective amount of the isolated monoclonal antibody or any antigen-binding fragment thereof, the bispecific molecule, the immunoconjugate or the pharmaceutical composition.
    Type: Application
    Filed: November 25, 2015
    Publication date: June 2, 2016
    Inventors: Ohad MAZOR, Ronit ROSENFELD, Arie ORDENTLICH, Tal NOY-PORAT