Abstract: A system and method for early detection of adverse physiological phenomenon such as anastomotic leakage through a tissue-of-interest monitoring electrode implanted in proximity to a site of interest internal to the body. The tissue-of-interest monitoring electrode is operative provide an electrical signal responsive to changes in physiological conditions at the site of interest. The electrical signals may be provided to by a communication device to a monitor which comprises circuitry that is operative to process the received signals for determining, for example, if GI leakage occurs or not. If leakage is detected, the monitor issues a warning indicating that leakage occurs.