Patents by Inventor Tamás ALTSACH

Tamás ALTSACH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of treprostinil
    Patent number: 11724979
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Grant
    Filed: July 15, 2021
    Date of Patent: August 15, 2023
    Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
  • PROCESS FOR THE PREPARATION OF TREPROSTINIL
    Publication number: 20210340093
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Application
    Filed: July 15, 2021
    Publication date: November 4, 2021
    Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
  • Process for the preparation of treprostinil
    Patent number: 11098001
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: August 24, 2021
    Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
  • PROCESS FOR THE PREPARATION OF TREPROSTINIL
    Publication number: 20190248725
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anhydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Application
    Filed: April 29, 2019
    Publication date: August 15, 2019
    Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS
  • Process for the preparation of treprostinil
    Patent number: 10322990
    Abstract: Treprostinil is a synthetic prostacyclin derivative with thrombocyte aggregation inhibitory and vasodilatory activity. Treprostinil can be administered in subcutaneous, intravenous, inhalable, or oral forms. Disclosed is a method for the preparation of treprostinil of formula I and its amorphous form, anydrate form, monohydrate form, and polyhydrate form salts with bases. In the disclosed method, the chiral center in the 3-hydroxyoctyl substituent is formed at the end of the synthesis, so that the method is robust and well scalable. Also disclosed are treprostinil intermediates and the preparation of the intermediates.
    Type: Grant
    Filed: September 28, 2015
    Date of Patent: June 18, 2019
    Assignee: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre Juhász, Irén Hortobágyi, Tamás Altsach, István Lászlófi, Ágnes Nagyné Borkó, Imre Rozsumberszki, Gábor Havasi, Zsuzsanna Kardos, Péter Buzder-Lantos
  • PROCESS FOR THE PREPARATION OF TREPROSTINIL
    Publication number: 20170313643
    Abstract: The invention provides a new process for the preparation of treprostinil of formula (I) and its salts using several new intermediates during the building of the ring system.
    Type: Application
    Filed: September 28, 2015
    Publication date: November 2, 2017
    Applicant: CHINOIN GYÓGYSZER ÉS VEGYÉSZETI TERMÉKEK GYÁRA ZRT.
    Inventors: Imre JUHÁSZ, Irén HORTOBÁGYI, Tamás ALTSACH, István LÁSZLÓFI, Ágnes NAGYNÉ BORKÓ, Imre ROZSUMBERSZKI, Gábor HAVASI, Zsuzsanna KARDOS, Péter BUZDER-LANTOS