Patents by Inventor Tamás Gregor

Tamás Gregor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dasatinib salts
    Patent number: 10023566
    Abstract: The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.
    Type: Grant
    Filed: May 26, 2015
    Date of Patent: July 17, 2018
    Assignee: EGIS GYOGYSZERGYAR ZRT
    Inventors: Ede Laszlo Marvanyos, Attila Virag, Tamas Gregor, Balazs Volk, Maria Tothne Lauritz, Laszlo Pongo, Balazs Peregi, Gyula Lukacs, Zoltan Varga, Andras Dancso
  • DASATINIB SALTS
    Publication number: 20170183334
    Abstract: The invention relates to normal or acidic salts of dasatinib and the hydrate and solvate forms thereof. More specifically the invention concerns: dasatinib cyclamic acid salt, dasatinib cyclamic acid (1:1) salt Form I, dasatinib cyclamic acid (1:1) salt Form II, dasatinib hydrogen bromide (1:2) salt, dasatinib methane sulfonic acid (1:2) salt, dasatinib p-toluenesulfonic acid (1:1) dihydrate salt, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form I, anhydrous dasatinib p-toluenesulfonic acid (1:1) salt Form II, dasatinib p-toluenesulfonic acid (1:1) salt methanol solvate. Moreover the invention relates process for preparing dasatinib salts, pharmaceutical compositions comprising thereof and the use of dasatinib salts the treatment of cancer.
    Type: Application
    Filed: May 26, 2015
    Publication date: June 29, 2017
    Applicant: EGIS GYOGYSZERGYAR ZRT
    Inventors: Ede Laszlo MARVANYOS, Attila VIRAG, Tamas GREGOR, Balazs VOLK, Maria TOTHNE LAURITZ, Laszlo PONGO, Balazs PEREGI, Gyula LUKACS, Zoltan VARGA, Andras DANCSO
  • Process for preparing pharmaceutical compounds and intermediate compounds
    Patent number: 9169265
    Abstract: The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: October 27, 2015
    Assignee: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikö Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
  • PROCESS FOR PREPARING A PHARMACEUTICAL COMPOUND
    Publication number: 20130030183
    Abstract: The object of the present invention is a one-pot process for preparing the 2-acetoxy-5-(2-fluoro-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]-pyridine (prasugrel) of the formula (I) by reacting the 5,6,7,7a-tetrahydro-4H-tieno[3,2-c]-pyridine-2-on of the formula (II) with 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)-etanone of the formula (III) or with 2-chloro-1-cyclopropyl-2-(2-fluorphenyl)-etanone of the formula (IIIa) and acetylating of the formed compound of the formula (IV), wherein the reaction is carried out in the presence of an organic base with an acetylation agent without isolating the compound of the formula (IV). The coupling and acetylation are carried out in the presence of the same organic base such as triethylamine, N,N-diisopropyl-ethylamine or pyridine. At the end of the process the prasugrel of the formula (I) is purified by recrystallization from an organic solvent or a mixture of solvents.
    Type: Application
    Filed: December 21, 2010
    Publication date: January 31, 2013
    Applicant: EGIS GYOGYSZERGYAR NYILVANOSAN MUKODO RESZVENYTARSASAG
    Inventors: Márta Porcs-Makkay, Tamás Gregor, Balázs Volk, Gábor Németh, József Barkóczy, Bálint Nyulasi, Tibor Mezei, György Ruzsics, Angéla Pandur, Erika Szilágyi, Kálmán Nagy, Péter Slégel, Enikö Molnár, Jözsef Debreczeni
  • PROCESS FOR PREPARING PHARMACEUTICAL COMPOUNDS AND INTERMEDIATE COMPOUNDS
    Publication number: 20120330018
    Abstract: The object of the present invention is a process for preparing the 2-acetoxy-5-(2-fluor-?-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts form crystalline 5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 27, 2012
    Applicant: Egis Gyogyszergyar Nyilvanosan Mukodo Reszvenytarsasag
    Inventors: Márta Porcs-Makkay, Balázs Volk, Tamás Gregor, József Barkóczy, Tibor Mezei, Judit Broda, Bálint Nyulasi, György Ruzsics, Enikõ Molnár, József Debreczeni, Kálmán Nagy, Angéla Pandur, Zsuzsanna Szent-Királlyi
  • Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
    Patent number: 7396931
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I)
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: July 8, 2008
    Assignee: Egis Gyógyszergyár Rt.
    Inventors: Péter Kótay Nagy, Gyula Simig, József Barkóczy, Tamás Gregor, Béla Farkas, Györgyi Vereczkeyné Donáth, Kálmán Nagy, Gyuláné Körtvélyessy, Zsuzsanna Szent-Királlyi
  • Process for the preparation of crystalline polymorph of a platelet aggregation inhibitor drug
    Publication number: 20070142637
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I).
    Type: Application
    Filed: June 30, 2004
    Publication date: June 21, 2007
    Applicant: EGIS GYOGYSZERGYAR RT.
    Inventors: Gyorgyi Vereczkeyne Donath, Kalman Nagy, Gyulane Kortvelyessy, Zsuzsanna Szent-Kirallyi, Peter Kotay Nagy, Gyula Simig, Jozsef Barkoczy, Tamas Gregor, Bela Farkas
  • Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
    Publication number: 20070117837
    Abstract: The present invention relates to a new method of preparation of the polymorph form 1 of methyl (S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl-acetate hydrogensulfate of the formula (I).
    Type: Application
    Filed: June 30, 2004
    Publication date: May 24, 2007
    Applicant: EGIS GYOGYSZERGYAR RT.
    Inventors: Peter Kotay Nagy, Gyula Simig, Jozsef Barkoczy, Tamas Gregor, Bela Farkas, Gyorgyi Vereczekeyne Donath, Kalman Nagy, Gyulane Kortvelyessy, Zsuzsanna Szent-Kirallyi
  • Polymorphs of clopidogrel hydrochloride and their use as antithrombic compounds
    Publication number: 20050113406
    Abstract: The invention relates to crystalline forms I and II methyl-(S)-(+)-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2.c]pyridine-5-yl)-acetate hydrochloride of the Formula (I) and hydrates thereof, a process for the preparation thereof and pharmaceutical compositions containing the same. The new polymorphs according to the invention exhibit blood platelet aggregation inhibiting and antithrombotic effect.
    Type: Application
    Filed: December 20, 2002
    Publication date: May 26, 2005
    Inventors: Peter Nagy, Jozsef Barkoczy, Gyula Simig, Zsuzsa Szent Kirallyi, Tamas Gregor, Bela Farkas, Gyorgyi Donath, Kalman Nagy, Gyulane Kortvelyessy