Abstract: A reaction-crystallization apparatus for carrying out reaction and/or solvent extraction and/or crystallization of soluble salts has an upper section having a top and a decanter. The decanter has a vertical vessel having a horizontal weir at the top of the upper section. The top of the upper section has an outlet for removing a light phase at the top of the decanter. The apparatus has a lower section, including a crystallizer. The crystallizer includes: a coaxial draft tube; a feed pipe; an agitator inside the draft tube; and at least one outlet at the bottom for crystal slurry removal. The apparatus has an intermediate section sandwiched between the lower section and the upper section such that the sections are in fluid communication and includes at least one coaxial vertical baffle with a gap between the draft tube and the coaxial vertical baffle and is adjustable by moving the baffle.

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract: A reaction-crystallization apparatus for carrying out reaction and/or solvent extraction and/or crystallization of soluble salts has an upper section having a top and a decanter. The decanter has a vertical vessel having a horizontal weir at the top of the upper section. The top of the upper section has an outlet for removing a light phase at the top of the decanter. The apparatus has a lower section, including a crystallizer. The crystallizer includes: a coaxial draft tube; a feed pipe; an agitator inside the draft tube; and at least one outlet at the bottom for crystal slurry removal. The apparatus has an intermediate section sandwiched between the lower section and the upper section such that the sections are in fluid communication and includes at least one coaxial vertical baffle with a gap between the draft tube and the coaxial vertical baffle and is adjustable by moving the baffle.

Abstract: The present invention relates to methods for detecting, prognosing and staging cancers, in particular cancers of the gastrointestinal tract. The methods of the invention comprise detecting specific protein markers in a tissue of interest, wherein the detected levels thereof may be indicative of pre-cancerous or cancerous tissue, or the stage or prognosis of a cancer. Further provided are methods of treating cancer, and cancer detection kits.

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.

Abstract: A method of identifying peptides originating from a particular cell type and being capable of binding to MHC molecules of a particular haplotype is disclosed. The method comprises obtaining a cell type expressing a soluble and secreted form of the MHC molecules of the particular haplotype; collecting the soluble and secreted form of the MHC molecules of the particular haplotype; and analyzing peptides bound to the soluble and secreted form of the MHC molecules of the particular haplotype, thereby identifying the peptides originating from the particular cell type and being capable of binding to MHC molecules of the particular haplotype.