Patents by Inventor Tamas Cseefalvi

Tamas Cseefalvi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microfluidic pH-stat for point of care (POC) enzyme diagnostics
    Patent number: 11709146
    Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: July 25, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Miklos Gratzl, Tamas Cseefalvi, Christian Zorman, John W. Stanton, Zhehao Zhang
  • MICROFLUIDIC pH-STAT FOR POINT OF CARE (POC) ENZYME DIAGNOSTICS
    Publication number: 20200173951
    Abstract: A microfluidic pH-stat with a specially-is designed slide and portable device can be used for point-of-care enzyme diagnostics. The slide includes a microchamber and a substrate for the enzyme being tested. The substrate is homogenized with the sample in the microchamber to form a test volume. The microchamber includes a working microelectrode that injects current to split water in the test volume to generate hydrogen ions and/or hydroxide ions and a micro-pH-electrode to measure a pH of the test volume; the slide also includes a reference microelectrode. The device includes a processor to adjust the injected current based on the pH of the test volume and determine an activity of the enzyme based on an amount the injected current is adjusted.
    Type: Application
    Filed: December 3, 2019
    Publication date: June 4, 2020
    Inventors: Miklos Gratzl, Tamas Cseefalvi, Christian Zorman, John Stanton, Zhahao Zhang