Abstract: ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. It has been found that in cells expressing functional ABCG2, ABCB1, or ABCC1 transporters, cellular PG fluorescence is strongly reduced. The invention relates to methods and uses of fluorescein derivative ester compounds of formula Ia which are analogs of PG for assessing ABC transporter activity of ABC multidrug transporters. The present accumulation assay is a novel tool for the parallel determination of the function of the multidrug transporters, in particular ABCG2, ABCB1, and ABCC1. The assay is applicable for diagnostic purposes and also allows the selection, separation and culturing of selected cell populations expressing such transporters.

Abstract: The present invention relates to a process for the preparation of iloprost of formula I through new intermediates, isolation of iloprost of formula I in solid form, as well as preparation of the 16(S)-iloprost and 16(R)-iloprost isomers of formulae (S)-I and (R)-I and isolation of iloprost of formula I and 16(S)-iloprost of formula (S)-I in solid, crystalline form.

Abstract: In the process of the present invention, cariprazine is prepared by converting (trans-4-amino-cyclohexyl)-acetic acid ethyl ester hydrochloride to trans-4-aminocyclohexyl) acetic acid or its hydrochloride by hydrolysis, from the obtained product with addition of dimethylcarbamoyl derivative as a suitable reagent (trans-4-{[(dimethylamino)carbonyl]amino}cyclohexyl) acetic acid is formed, then the obtained compound is linked to 1-{2,3-dichlorophenyl)˜piperazine in the presence of carboxylic acid activating coupling reagent, and so 1,1-dimethyl-3-[trans-4-(2-oxo-2-(4-(2,3-dichlorophenyl)piperazin-1-yl-ethyl)cyclohexyl] urea is formed, which is converted to cariprazine borane adduct of formula (2) in the presence of reducing agent, and finally the product itself is eliminated directly or is obtained from its salt by a known method. The invention also relates to a group of intermediate compounds that are formed and/or used in the process according to the present invention.

Abstract: In the process of the present invention, cariprazine is prepared by converting (trans-4-amino-cyclohexyl)-acetic acid ethyl ester hydrochloride to trans-4-aminocyclohexyl) acetic acid or its hydrochloride by hydrolysis, from the obtained product with addition of dimethylcarbamoyl derivative as a suitable reagent (trans-4-{[(dimethylamino)carbonyl]amino}cyclohexyl) acetic acid is formed, then the obtained compound is linked to 1-{2,3-dichlorophenyl)˜piperazine in the presence of carboxylic acid activating coupling reagent, and so 1,1-dimethyl-3-[trans-4-(2-oxo-2-(4-(2,3-dichlorophenyl)piperazin-1-yl-ethyl)cyclohexyl] urea is formed, which is converted to cariprazine borane adduct of formula (2) in the presence of reducing agent, and finally the product itself is eliminated directly or is obtained from its salt by a known method. The invention also relates to a group of intermediate compounds that are formed and/or used in the process according to the present invention.

Abstract: The invention relates to a fuel pump assembly, which comprises a fuel pump (2), a fuel tank (3), in which the fuel pump (2) is at least partially arranged, an intermediate component (4), which is arranged on the outside of the fuel tank (3) and has a fuel connection to the fuel tank (3), and a filter (5), which is arranged in a filter chamber (6) and is arranged on the outside of the intermediate component (4) or the fuel pump (2). According to the invention, a fuel flow flows from an interior (30) of the fuel tank (3) through a first opening (40) of the intermediate component (4) outward into the filter chamber (6) and from the filter chamber (6) through the filter (5) and through a second opening (41) of the intermediate component (4) to an inlet (20) of the fuel pump (2).

Abstract: The field of invention relates to a novel process, suitable for industrial scale manufacture, for the preparation of high-purity 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-yl acetate, prasugrel, of Formula (I). Especially in large-scale production, one of the main causes of piling up the impurities is the use of ether solvents consequently in each step in this procedure ethers are excluded. Avoiding the ethers resulted new conditions for production of intermediates in the different steps of our procedure. Conditions were determined so that each step from the beginning contributes to minimizing the impurity content of the end-product.

Abstract: The invention relates to a fuel pump assembly, which comprises a fuel pump (2), a fuel tank (3), in which the fuel pump (2) is at least partially arranged, an intermediate component (4), which is arranged on the outside of the fuel tank (3) and has a fuel connection to the fuel tank (3), and a filter (5), which is arranged in a filter chamber (6) and is arranged on the outside of the intermediate component (4) or the fuel pump (2). According to the invention, a fuel flow flows from an interior (30) of the fuel tank (3) through a first opening (40) of the intermediate component (4) outward into the filter chamber (6) and from the filter chamber (6) through the filter (5) and through a second opening (41) of the intermediate component (4) to an inlet (20) of the fuel pump (2).

Abstract: A method for the production of an additive for building materials, wherein a hidrophobization agent is mixed with a solvent and the resulting emulsion is applied to quicklime, and then the material obtained is hydrated by adding water, wherein the hidrophobization agent is an oil having a dry matter content of 3 to 50% by weight, the quicklime in a quantity of 60 to 96% by weight is soaked with a quantity of 4 to 40% by weight of the mixture of the oil and the solvent, and after dying of the hydrated material a foaming agent is admixed thereto in a quantity of 0.25 to 0.6 part by weight of the foaming agent, preferably sodium bicarbonate, to one part by weight of the hydrated material. By using this additive, a binder comprising an additive is produced so that a hydraulic binding component and/or an isocyanate based binding component are/is added to the additive in a quantity of 4.8 to 14.8 parts by weight of the binding component to one part by weight of the additive.

Abstract: A method and system for large data transfer between a sender and a receiver. The sender transmits to the receiver a plurality of data packets in sequence. The time elapsed for each of the plurality of data packets after transmission of said each of the plurality of data packets is determined. The receiver transmits a message from the receiver to the sender notifying the sender that an identified one of the plurality of the data packets is missing. The sender retransmits to the receiver the identified one of the plurality of data packets only when the elapsed time determined for the identified one of the plurality of the data packets is greater than a predetermined time interval.

Abstract: A method is described for generating an undisturbed signal out of an audio signal including a disturbing signal. The method comprises the steps of: estimating auto-correlation matrices and cross-correlation vectors of the equation of the Wiener filtering problem, calculating the coefficients of the solution vector of the equation of the Wiener filtering problem, evaluating the quality of the calculated coefficients, controlling the estimation step depending on the quality of the calculated coefficients, generating a correction signal out of the disturbing signal depending on the calculated coefficients, and correcting the audio signal depending on the correction signal.

Abstract: A method and system for large data transfer between a sender and a receiver. The sender transmits to the receiver a plurality of data packets in sequence. The time elapsed for each of the plurality of data packets after transmission of said each of the plurality of data packets is determined. The receiver transmits a message from the receiver to the sender notifying the sender that an identified one of the plurality of the data packets is missing. The sender retransmits to the receiver the identified one of the plurality of data packets only when the elapsed time determined for the identified one of the plurality of the data packets is greater than a predetermined time interval.

Abstract: Method of thin layer preparation for a radionuclide source comprising the following steps:

Abstract: Method of thin layer preparation for a radionuclide source comprising the following steps: deposition of a drop of a radionuclide dissolved in a solvent onto a on a support substrate, placing said support substrate with said drop in a confined space with a reduced pressure, directing at least one flow of a hot gas onto the drop, rotating the source relative to the hot gas jet creating turbulences inside the drop, evaporating the solvent and obtaining a thin layer of dry radionuclide.

Abstract: Method of thin layer preparation for a radionuclide source comprising the following steps:

Abstract: Improved secondary and tertiary oil recovery process in which water-soluble, salt-insensitive, block polymers of the A-B-A type wherein the A block is derived from a water-soluble monomer and the B block is derived from N-vinyl pyrrolidone are used as viscosity control agents.

Abstract: A method and system for large data transfer between a sender and a receiver. The sender transmits to the receiver a plurality of data packets in sequence. The time elapsed for each of the plurality of data packets after transmission of said each of the plurality of data packets is determined. The receiver transmits a message from the receiver to the sender notifying the sender that an identified one of the plurality of the data packets is missing. The sender retransmits to the receiver the identified one of the plurality of data packets only when the elapsed time determined for the identified one of the plurality of the data packets is greater than a predetermined time interval.

Abstract: A method and system for large data transfer between a sender and a receiver. The sender transmits to the receiver a plurality of data packets in sequence. The time elapsed for each of the plurality of data packets after transmission of said each of the plurality of data packets is determined. The receiver transmits a message from the receiver to the sender notifying the sender that an identified one of the plurality of the data packets is missing. The sender retransmits to the receiver the identified one of the plurality of data packets only when the elapsed time determined for the identified one of the plurality of the data packets is greater than a predetermined time interval.