Patents by Inventor Tamas Szuts
Tamas Szuts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10344032Abstract: The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.Type: GrantFiled: October 28, 2014Date of Patent: July 9, 2019Assignee: Pécsi TudományegyetemInventors: János Szolcsányi, Erika Pintér, Zsuzsanna Helyes, Éva Szöke, Frigyes Wáczek, László Örfi, György Kéri, Tamás Szüts
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Publication number: 20170260187Abstract: The present invention relates to 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives of the and solvates, hydrates and pharmaceutically acceptable salts thereof, processes for manufacturing of them, the use of them, as well as pharmaceutical N compositions containing at least one of them as pharmaceutically active agent(s) together with pharmaceutically acceptable carrier, excipient and/or diluents, especially for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia. Said 4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine compounds have been identified as new drug candidates for the prevention and/or treatment of acute neurogenic inflammation and/or neuropathic hyperalgesia.Type: ApplicationFiled: October 28, 2014Publication date: September 14, 2017Inventors: János SZOLCSÁNYI, Erika PINTÉR, Zsuzsanna HELYES, Éva SZÖKE, Frigyes WÁCZEK, László ÖRFI, György KÉRI, Tamás SZÜTS
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Publication number: 20080214583Abstract: The invention relates to new 7H-pyrrolo[2,3-d]pyrimidine derivatives, as well as their therapeutically acceptable salts, pharmaceutical preparations containing them and process for producing the active agent. The pharmaceutical preparation is adventageously antiphlogistic and analgetic one, a preparation reducing neuropathic hyperalgesia and rheumatic arthritis, a preparation for hindering destruction of bones chondrus, being applicable for treatment of other diseases, which may be connected with other inflammatory processes e.g. asthma, eczema or psoriasis.Type: ApplicationFiled: April 25, 2005Publication date: September 4, 2008Inventors: Janos Szolcsanyi, Laszlo Orfi, Gyorgy Keri, Frigyes Waczek, Erika Pinter, Zsusanna Helyes, Tamas Szuts, Jozsef Nemeth
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Patent number: 5380761Abstract: An anhydrous transdermal composition is disclosed comprising in a 20 to 100% lyotropic liquid crystalline arrangement:5 to 15 weight % of optically active or racemic N-methyl-N-(1-phenyl-2-propyl)-2-propynylamine or N-methyl-N-{1-(4-fluorophenyl)-2-propyl}-2-propynylamine or a pharmaceutically acceptable salt thereof;40 to 70% by weight of liquid polyethylene glycol;10 to 20% by weight of solid polyethylene glycol;2 to 30% by weight of a nonionic surface active agent;2 to 20% by weight of propylene glycol, and if desired,0.5 to 2% by weight of a polymer, the a value of which is greater than 0.6, andoptionally, in an amount needed up to 100% an emulsifying agent.Type: GrantFiled: October 20, 1993Date of Patent: January 10, 1995Assignee: Chinoin Gyogyszer- ES Vegyeszeti Termekek Gyara RT.Inventors: Szabo Anna Z., Gabriella Szabo nee Ujhelyi, Antal Toth, Tamas Szuts, Kalman Magyar, Jozsef Lengyel, Janos Pinter, Anna Szekely, Andras Szego, Katalin Marmarosi nee Kellner
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Patent number: 5294712Abstract: The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen: or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt.The compounds of the Formula I are known antibacterial agents.Type: GrantFiled: September 14, 1990Date of Patent: March 15, 1994Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Keresturi, Lelle V. Debreczy, Agnes Horvath, Maria Balogh, Gabor Kovacs, Tamas Szuts, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 5284950Abstract: A method of using a compound of the Formula (V) ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, wherein R.sup.1 and R.sup.2 are each C.sub.1 to C.sub.6 aliphatic acyloxy, unsubstituted or substituted by halogen, or are each C.sub.7 to C.sub.Type: GrantFiled: April 25, 1991Date of Patent: February 8, 1994Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Kereszturi, Lelle Vasvari nee Debreczy, Agnes Horvath, Maria Balogh, Gabor Kovacs, Tamas Szuts, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 5244880Abstract: The invention relates to novel stable aqueous primycin solutions containing 0.5 to 1.75% by mass/volume of primycin sulfate or 2.5 to 9% by mass/volume of a complex of primycin N-methylpyrrolidone and 2 to 15% by mass/volume of pyroglutamic acid, preferably L-pyroglutamic acid or a soluble salt, preferably the sodium salt thereof as calculated for the volume of the solution to be prepared and 40 to 60% by volume of isopropanol as calculated for the volume of the solution to be prepared as well as water in an amount adding up to 100%. The stable, aqueous primycin solutions are topical antibiotics.Type: GrantFiled: February 11, 1992Date of Patent: September 14, 1993Assignee: Chinoin Gyogyszer- es Vegyeszeti Termekek GyaraInventors: Peter Szentmiklosi, Tamas Szuts, Gyorgy Hidasi, Istvan Juhasz
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Patent number: 5064815Abstract: This invention relates to a primycin-containing colloidal basic gel comprising 5-30% of primycin and 95-70% of N-methyl-pyrrolidone-2. The invention also relates to antibacterial compositions particularly for the treatment of acne vulgaris comprising as active ingredient 0.1-100% of a primycin-containing colloidal basic gel, if desired together with further antimicrobial active ingredients, in admixture with 99.9-0% of usual inert pharmaceutical filling, diluting and other formulating additives. The invention also relates to combination composition comprising as active ingredient 1-60% of a primycin-containing colloidal basic gel and 0.1-40% of further pharmaceutical active ingredient(s), e.g. one or more antibiotic(s), chemotherapeutical agent(s), fungistatic or fungicidal agent(s), steroidal or non-steroidal antiinflammatory agent (s), epithelogenic agent(s), local anaesthetic(s), and/or vitamin(s).Type: GrantFiled: March 26, 1990Date of Patent: November 12, 1991Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Peter Szentmiklosi, Tamas Szuts, Jozsef Nemes, Jozsef Lengyel, Jeno Marton, Peter Sarkozi, Erzsebet Babos nee Vajas, Eniko Schreiner nee Kovats
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Patent number: 5043326Abstract: The invention relates to the inclusion complexes of 7-isopropoxy-isoflavon formed with cyclodextrin or cyclodextrin derivatives as well as to the pharmaceutical compositions containing these inclusion complexes as active ingredient. The invention further relates to the preparation of the new inclusion complexes.The new inclusion complex according to the invention shows higher dissolution and resorption properties as compared to the active ingredient administered per se.Type: GrantFiled: November 27, 1989Date of Patent: August 27, 1991Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Agnes Stadler nee Szoke, Josef Szejtli, Viktor Weiszfeiler, Zoltan Vargay, Katalin Kaloy, Vera Gergely, Tamas Szuts
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Patent number: 4981966Abstract: The invention relates to a new process for the preparation of compounds of the Formula I ##STR1## (wherein R stands for hydrogen or methyl) and pharmaceutically acceptable salts thereof which comprises reacting a compound of the Formula V ##STR2## (wherein R.sup.1 and R.sup.2 stand for an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or for an aromatic acyloxy group comprising 7-11 carbon atoms) with an amine of the Formula VI ##STR3## (wherein R has the same meaning as stated above) or a salt thereof and subjecting the compound of the Formula VII ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) to hydrolysis after or without isolation and if desired converting the compound of the Formula I thus obtained into a salt thereof or setting free the same from its salt.The compounds of the Formula I are known antibacterial agents.Type: GrantFiled: January 10, 1989Date of Patent: January 1, 1991Assignee: Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Kereszturi, Lelle Vasvari nee Debreczy, Agnes Horvath, Maria Balogh, Gabor Kovacs, Tamas Szuts, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 4871849Abstract: The present invention relates to a process for the preparation of compounds of the general Formula I ##STR1## and pharmaceutically acceptable salts thereof (wherein R stands for piperazinyl or 4-methyl-piperazinyl) which comprises reacting a compound of the general Formula II ##STR2## (wherein R.sup.1 and R.sup.2 stand for halogen; an aliphatic acyloxy group comprising 2-6 carbon atoms and optionally substituted by halogen; or an aromatic acyloxy group comprising 7-11 carbon atoms) with a piperazine of the general Formula III ##STR3## (wherein R.sup.3 represent hydrogen or methyl) or a salt thereof, hydrolysing the compound of the general Formula IV ##STR4## thus obtained (wherein R, R.sup.1 and R.sup.2 are as stated above) without or after hydrolysis and if desired converting the compound of the general Formula I thus obtained into a salt thereof or setting free the same from its salt.The compounds of the general Formula I are known antibacterial agents.Type: GrantFiled: June 24, 1987Date of Patent: October 3, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Geza Kereszturi, Lelle Vasvavi, Agnes Horvath, Maria Balogh, Gabor Kovacs, Tamas Szuts, Peter Ritli, Judit Sipos, Aniko Pajor
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Patent number: 4826963Abstract: The invention relates to the inclusion complexes of 7-isopropoxy-isoflavone formed with cyclodextrin or cyclodextrin derivatives as well as to the pharmaceutical compositions containing these inclusion complexes as active ingredient. The invention further relates to the preparation of the new inclusion complexes. The new inclusion complex according to the invention shows higher dissolution and resorption properties as compared to the active ingredient administered per se.Type: GrantFiled: September 10, 1986Date of Patent: May 2, 1989Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara, R.T.Inventors: Agnes Stadler nee Szoke, Jozsef Szejtli, Viktor Weiszfeiler, Zoltan Vargay, Katalin Kaloy, Vera Gergely, Tamas Szuts
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Patent number: 4670440Abstract: N,N,N-trimethyl-2-hydroxyethyl-ammonium-[1-ethyl-6-fluoro-4-oxo-7-(1-pipera zinyl)-1,4-dihydro-quinolizine-3-carboxylate] of the formula I ##STR1## as a norfloxacin antimicrobial salt capable of enteral administration.Type: GrantFiled: April 21, 1986Date of Patent: June 2, 1987Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara RT.Inventors: Tamas Szuts, Peter Szentmiklosi, Jozsef Lengyel, Istvan Hermecz, Lelle Vasvari nee Debreczy, Agnes Horvath, Geza Kerszturi, Gabor Kovacs, Gabor Horvath, Katalin Marmarosi nee Kellner
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Patent number: 4581348Abstract: The present invention relates to synergistic pharmaceutical compositions for the treatment of liver disorders comprising 5-aminoimidazole-4-carboxamide orthophosphate (AICA-phosphate) as active ingredient in association with vitamins, preferably with vitamin B and/or E and optionally with other pharmaceutical excipients.Type: GrantFiled: July 11, 1984Date of Patent: April 8, 1986Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.Inventors: Jozsef Schawartz, Maria Hornyak, Tamas Szuts, Jozsef Lengyel, Karoly Lapis, Janos Feher, Sandor Virag, Gyula Sebestyen, Katalin Kalloy, Katalin Marmarosi
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Patent number: 4565817Abstract: Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,R.sub.2 stands for hydrogen or straight or branched chain alkyl,R.sub.3 stands for hydrogen or straight or branched chain alkyl or,R.sub.2 and R.sub.3 together with the nitrogen atom may form a 5-6 membered ring, which ring can optionally contain an oxygen or a second nitrogen atom, the latter, optionally substituted by methyl or,R.sub.1 can stand for a phenyl group of the formulaR.sub.4 R.sub.5 C.sub.6 H.sub.3whereinR.sub.4 and R.sub.5 represent independently hydrogen, chlorine, hydroxy, methoxy, ethoxy, methyl or amino or,R.sub.Type: GrantFiled: March 11, 1983Date of Patent: January 21, 1986Assignee: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.Inventors: Dezso Korbonits, Maria Szomor nee Wundele, Gergely Heja, Ida Szvoboda nee Kanzel, Pal Kiss, Csaba Gonczi, Endre Palosi, Gabor Kovacs, Judit Kun, Emil Minker, Sandor Virag, Gyula Sebestyen, Tamas Szuts
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Patent number: 4472399Abstract: New Rutecarpine analogs are disclosed having Rutecarpine-like activity, especially diuretic activity. Also a novel process for the preparation of the Rutecarpine analogs is disclosed.Type: GrantFiled: October 2, 1981Date of Patent: September 18, 1984Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Rt.Inventors: Jozsef Kokosi, Istvan Hermecz, Zoltan Meszaros, Sandor Virag, Lelle Vasvari, nee Debreczy, Gyorgy Szasz, Agnes Horvath, Tibor Breining, Tamas Szuts, Gyula Sebestyen
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Patent number: 4260612Abstract: Antiallergic and antiasthmatic compounds of the formula ##STR1## of which 9-phenylamino-6-methyl-4-oxo-6,7-dihydro-4H-pyrido(1,2-a)pyrimidine-3-carb oxylic acid and optically active antipodes and salts thereof are examples.Type: GrantFiled: December 11, 1978Date of Patent: April 7, 1981Assignee: Chinoin Gyogyszer es Vecyeszeti Termekek Gyara Rt.Inventors: Istvan Hermecz, Zoltan Meszaros, Tibor Breining, Sandor Virag, Lelle Vasvari nee Debreczi, Agnes Horvath, Gabor Nagy, Attila Mandi, Tamas Szuts, Istvan Bitteer, Gyula Sebestyen