Patents by Inventor Tamer I. KHAYAL

Tamer I. KHAYAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE AND FOR USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS
    Publication number: 20190261626
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 29, 2019
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth (Hansen) BULGER
  • SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE
    Publication number: 20190246630
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Application
    Filed: April 26, 2019
    Publication date: August 15, 2019
    Inventors: Waleed H. HASSANEIN, Richard BRINGHAM, Giovanni CECERE, Tamer I. KHAYAL, Ronald TAYLOR, Jr., Hossam ALGAMIL
  • System and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
    Patent number: 10321676
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: June 18, 2019
    Assignee: TRANSMEDICS, INC.
    Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen Bulger
  • Systems and methods for ex-vivo organ care
    Patent number: 10314303
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: June 11, 2019
    Assignee: TRANSMEDICS, INC.
    Inventors: Waleed H. Hassanein, Richard Bringham, Giovanni Cecere, Tamer I. Khayal, Ronald Taylor, Jr., Hossam Algamil
  • EX VIVO ORGAN CARE SYSTEM
    Publication number: 20190021308
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 24, 2019
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Jeff BARNES, Greg RITCHIE, Richard BRINGHAM, Mark ANDERSON, John SULLIVAN
  • SYSTEMS, METHODS, COMPOSITIONS AND SOLUTIONS FOR PERFUSING AN ORGAN
    Publication number: 20190014774
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 17, 2019
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
  • Ex vivo organ care system
    Patent number: 10076112
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Grant
    Filed: June 2, 2015
    Date of Patent: September 18, 2018
    Assignee: TRANSMEDIC, INC.
    Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Jeff Barnes, Greg Ritchie, Richard Bringham, Mark Anderson, John Sullivan
  • Systems, methods, compositions and solutions for perfusing an organ
    Patent number: 10039276
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Grant
    Filed: June 9, 2015
    Date of Patent: August 7, 2018
    Assignee: TRANSMEDICS, INC.
    Inventors: Waleed H. Hassanein, Tamer I. Khayal, Paul Lezberg
  • SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE AND FOR USING LACTATE AS AN INDICATION OF DONOR ORGAN STATUS
    Publication number: 20180153158
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
    Type: Application
    Filed: December 29, 2017
    Publication date: June 7, 2018
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Paul LEZBERG, Giovanni CECERE, Dennis SOUSA, Elizabeth HANSEN
  • Systems and methods for ex vivo lung care
    Patent number: 9516875
    Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: December 13, 2016
    Assignee: TRANSMEDICS, INC.
    Inventors: Robert Fishman, Robert Havener, Ihab A. Fattah, Anas Abdelazim, Scott Newell, Thomas H. Bishop, Tamer I. Khayal, Stanley Kyi, Ron Taylor, Jr., Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed H. Hassanein
  • SYSTEMS AND METHODS FOR EX-VIVO ORGAN CARE
    Publication number: 20160095308
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Application
    Filed: November 12, 2015
    Publication date: April 7, 2016
    Inventors: Waleed H. HASSANEIN, Richard BRINGHAM, Giovanni CECERE, Tamer I. KHAYAL, Ronald TAYLOR, Hossam ALGAMIL
  • SYSTEMS, METHODS, COMPOSITIONS AND SOLUTIONS FOR PERFUSING AN ORGAN
    Publication number: 20150342176
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Application
    Filed: June 9, 2015
    Publication date: December 3, 2015
    Applicant: TRANSMEDICS, INC
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
  • EX VIVO ORGAN CARE SYSTEM
    Publication number: 20150342177
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Application
    Filed: June 2, 2015
    Publication date: December 3, 2015
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Jeff BARNES, Greg RITCHIE, Richard BRINGHAM, Mark ANDERSON, John SULLIVAN
  • Systems and Methods for Ex Vivo Organ Care
    Publication number: 20150079580
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.
    Type: Application
    Filed: August 20, 2014
    Publication date: March 19, 2015
    Applicant: TRANSMEDICS, INC
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Robert HAVENER, Stanley KYI, Ihab Abdel FATTAH, Hesham SALEH, Jon C. TRACHTENBERG
  • ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS
    Publication number: 20130011823
    Abstract: An ex-vivo lung solution for machine perfusion of donor lungs on OCS. The solution may be mixed with whole blood or packed red blood cells to form the OCS lung perfusion solution.
    Type: Application
    Filed: April 13, 2012
    Publication date: January 10, 2013
    Inventors: Waleed H. Hassanein, Ihab A. FATTAH, Paul LEZBERG, Tamer I. KHAYAL, Robert HAVENER, Anas ABDELAZIM