Abstract: Provided herein are meniscus implant compositions, as well as methods for making and using the same. The subject meniscus implants find us in repairing and/or replacing damaged or diseased meniscal tissue in a mammalian subject.

Abstract: A print head, system and method for producing hollow fiber structures, for example three-dimensional biological structures comprising living cells, includes a dispensing channel, a core channel converging with the proximal end of the dispensing channel, a first shell channel converging with the core channel and the dispensing channel at a focusing intersection or chamber, and a sheath flow channel converging with the dispensing channel at a sheath flow intersection or chamber located between the focusing intersection or chamber and the distal end of the dispensing channel. The diameter of the dispensing channel increases from a first diameter to a second diameter at the sheath flow intersection or chamber, and the core channel has a third diameter less than the first and second diameters. The sheath flow channel includes sheath flow sub-channels and the focusing chamber has a conical frustum shape.

Abstract: A method for culturing heart tissue by culturing a slice of the heart tissue in a culture medium, wherein the culture medium comprises fetal bovine serum (FBS), vascular endothelial cell growth factor (VEGF), and fibroblast growth factor (FGF); and applying electrical stimulation to the slice while the heart slice is in culture is provided. Methods of screening candidate therapeutic agents for therapeutic effect or cardiotoxicity using the culture system are also provided.

Abstract: A compact sensor apparatus having an illumination beam, a beam shaping system, a polarization modulation system, a beam projection system, and a signal detection system. The beam shaping system is configured to shape an illumination beam generated from the illumination system and generate a flat top beam spot of the illumination beam over a wavelength range from 400 nm to 2000 nm. The polarization modulation system is configured to provide tenability of linear polarization state of the illumination beam. The beam projection system is configured to project the flat top beam spot toward a target, such as an alignment mark on a substrate. The signal detection system is configured to collect a signal beam comprising diffraction order sub-beams generated from the target, and measure a characteristic (e.g., overlay) of the target based on the signal beam.

Abstract: A sensor apparatus includes a sensor chip, an illumination system, a first optical system, a second optical system, and a detector system. The illumination system is coupled to the sensor chip and transmits an illumination beam along an illumination path. The first optical system is coupled to the sensor chip and includes a first integrated optic to configure and transmit the illumination beam toward a diffraction target on a substrate, disposed adjacent to the sensor chip, and generate a signal beam including diffraction order sub-beams generated from the diffraction target. The second optical system is coupled to the sensor chip and includes a second integrated optic to collect and transmit the signal beam from a first side to a second side of the sensor chip. The detector system is configured to measure a characteristic of the diffraction target based on the signal beam transmitted by the second optical system.

Abstract: A sensor apparatus includes a sensor chip, an illumination system, a first optical system, a second optical system, and a detector system. The illumination system is coupled to the sensor chip and transmits an illumination beam along an illumination path. The first optical system is coupled to the sensor chip and includes a first integrated optic to configure and transmit the illumination beam toward a diffraction target on a substrate, disposed adjacent to the sensor chip, and generate a signal beam including diffraction order sub-beams generated from the diffraction target. The second optical system is coupled to the sensor chip and includes a second integrated optic to collect and transmit the signal beam from a first side to a second side of the sensor chip. The detector system is configured to measure a characteristic of the diffraction target based on the signal beam transmitted by the second optical system.

Abstract: Synthesis of a compound 2-oxo-2-({2-[(phenylcarbamoyl)oxy]ethyl}amino)ethyl phenylcarbamate and its use as an insecticidal agent.

Abstract: Provided herein are meniscus implant compositions, as well as method for making and using the same. The subject meniscus implants find use in repairing and/or replacing damaged or diseased meniscal tissue in a mammalian subject.

Abstract: A method of fractionation of cannabis extracts via centrifugal post extraction processing is disclosed. The method may include extracting un-activated cannabis biomass, precipitating a cannabinoid solids into a raw cannabinoid extrat, and centrifugally fractionating the bulk extract. Centrifugally fractionating the bulk extract may include placing the extract in a batch, perforated basket centrifuge, separating cannabinoid solids from liquid terpenoid/plant fat fraction; and reformulating the resulting fractions to specified cannabinoid/terpenoid contents.

Abstract: A system includes a radiation source, first and second phased arrays, and a detector. The first and second phased arrays include optical elements, a plurality of ports, waveguides, and phase modulators. The optical elements radiate radiation waves. The waveguides guide radiation from a port of the plurality of ports to the optical elements. Phase modulators adjust phases of the radiation waves. One or both of the first and second phased arrays form a first beam and/or a second beam of radiation directed toward a target structure based on the port coupled to the radiation source. The detector receives radiation scattered by the target structure and generates a measurement signal based on the received radiation.

Abstract: A digitally controlled delay device includes a plurality of first delay stages connected in series between a first input port and a first output port, and a plurality of second delay stages connected in series between a second input port and a second output port. Each first delay stage of the plurality of first delay stages includes a plurality of first delay elements and each second delay stage of the plurality of second delay stages includes a corresponding plurality of second delay elements. A controller performs complementary control based on a digital control signal by controlling one or more of the plurality of first delay elements to be in a first control state and controlling a corresponding one or more of the plurality of second delay elements to be in a second control state, opposite the first control state.

Abstract: A circuit or reducing fractional spurs comprises a digital to time converter (DTC) comprising multiple delay stages electrically coupled to one another in series, configured such that each delay stage is binary switched till the code exceeds cell range and then it is fully turned ON, and thereafter it is moved to the next stage, each delay stage comprising a digitally controlled delay line (DCDL) having code-dependent integrated nonlinearity (INL), with the maximal value of the INL occuring at a mid-code position; and an offset stage comprising the DCDL electrically coupled to the DTC in series, configured to generate random codes for each required time delay of the DTC to ensure the probability of landing at the mid-code position is reduced and landing point is kept as far away as possible from the mid-code position for every required time delay, thereby improving the INL and the fractional spurs.

Abstract: The techniques described herein relate to duty cycle error calibration. An example apparatus includes a multi-modulus divider (MMD) circuit configured to receive a first digital code corresponding to a first time delay and included in a first plurality of digital codes associated with a first range of time delays, divide a clock signal by a divisor to generate a divided clock signal, and delay the divided clock signal by the first time delay to generate a delayed clock signal. The apparatus may further include a digitally controlled delay line (DCDL) circuit configured to receive a second digital code corresponding to a second time delay and included in a second plurality of digital codes associated with a second range of time delays, and delay the delayed clock signal by the second time delay to generate a feedback clock signal to reduce a difference between the feedback and a reference clock signal.

Abstract: A system to operate as a phase locked loop (PLL) includes a frequency synthesizer in a feedback path of the PLL and a delay line arranged to receive an output of the frequency synthesizer. A retimer subsystem is arranged to receive the output of the frequency synthesizer. A digitally controlled delay line (DCDL) is arranged to receive an output of the retimer. A phase detector is arranged to receive an output of the delay line and an output of the DCDL and to provide an error signal indicating a difference in phase of the output of the delay line relative to the output of the DCDL. A controller causes closed loop operation of the PLL during a normal operational mode and open loop operation during a calibration mode during which gain of the DCDL, defining a relationship between a control code and a resulting delay, is calibrated.

Abstract: The techniques described herein relate to digitally controlled delay line gain calibration using error injection. An example apparatus includes a digitally controlled delay line (DCDL) with a DCDL output and configured to: receive a clock signal to be output from a voltage-controlled oscillator, and delay the clock signal to generate a first delayed clock signal. The apparatus further includes an error injection circuit with a first error injection input and a second error injection input, the first error injection input coupled to the DCDL output. The apparatus additionally includes a phase controller with a phase controller output coupled to the second error injection input, the phase controller configured to, in response to a pseudorandom binary sequence signal, instruct the error injection circuit to generate a second delayed clock signal based on a delay of the first delayed clock signal.

Abstract: The techniques described herein relate to systems, apparatus, articles of manufacture, and methods for optimum loop gain calibration for clock data recovery and phase locked loop. An example apparatus includes a phase detector with a phase detector output and configured to generate an error signal representative of a difference between an input signal and a feedback signal. The apparatus further includes a calibrator circuit with a calibrator input coupled to the phase detector output and configured to determine correlation value associated with the error signal, and determine a gain value based on an adjustment of an absolute value of the correlation value by a pseudorandom binary sequence signal.

Abstract: A differential all-pass coupling circuit with common mode feedback is disclosed. An example apparatus includes an anti-aliasing circuit configured to reduce a bandwidth of a first differential signal, and a switched-capacitor circuit coupled to the anti-aliasing circuit configured to control a first switch to charge a capacitor to a first voltage based on a first difference between (i) a common mode input voltage associated with a first common mode voltage of the first differential signal and (ii) a common mode reference voltage associated with a second common mode voltage of an input stage of the receiver, control a second switch to provide a second voltage to the capacitor based on a second difference between the first differential signal and the common mode input voltage, and output a second differential signal to the input stage based on the first differential signal adjusted by the second voltage.

Abstract: The techniques described herein relate to analog-assisted feed-forward equalizers. An example apparatus includes a first charge element digital-to-analog converter (DAC) including a first plurality of charge storage elements configured to store first samples of charge based on respective first portions of a digital input signal, and generate, based on the first samples, a first analog output signal proportional to the first portions. The apparatus further includes a second charge element DAC coupled to the first charge element DAC and including a second plurality of charge storage elements configured to store second samples of charge based on respective second portions of the digital input signal, and generate, based on the second samples, a second analog output signal proportional to the second portions, and wherein the coupling of the first and second outputs generates a third analog output signal based on a combination of the first and second analog output signals.

Abstract: An ethyl 3-[4,4-bis(4-chlorophenyl)-2,5-dioxoimidazolidin-1-yl]propanoate compound, its synthesis, and its use as an antimicrobial agent.

Abstract: A system includes a radiation source, first and second phased arrays, and a detector. The first and second phased arrays include optical elements, a plurality of ports, waveguides, and phase modulators. The optical elements radiate radiation waves. The waveguides guide radiation from a port of the plurality of ports to the optical elements. Phase modulators adjust phases of the radiation waves. One or both of the first and second phased arrays form a first beam and/or a second beam of radiation directed toward a target structure based on the port coupled to the radiation source. The detector receives radiation scattered by the target structure and generates a measurement signal based on the received radiation.