Abstract: An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7) alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2.

Abstract: An anti-HIV composition comprising 2-carbamoyloxymethyl-5-(3,5-dichlorophenylthio)-4-isopropyl-1-(pyridin-4-y l)methyl-1H-imidazole or the pharmaceutical acceptable salt thereof and other one or more anti-HIV compounds is provided.

Abstract: An imidazole derivative represented by general formula (I) or a salt thereof, having the effect of specifically inhibiting the growth of HIV as a pathogenic virus and being reduced in toxicity. In said formula R.sup.1 represents hydrogen, C.sub.1 -C.sub.20 alkyl, C.sub.2 -C.sub.7 alkenyl, C.sub.4 -C.sub.12 cycloalkylalkyl, etc.; R.sup.2 represents C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 acyl, hydroxyiminomethyl, hydrazonomethyl or --(CH.sub.2)n--R.sup.4 (R.sup.4 being halogeno, alkoxy, hydroxy, etc.; and n being an integer of 1 to 3); R.sup.3 represents substituted or unsubstituted C.sub.1 -C.sub.6 alkyl; X and Y represent each independently hydrogen, C.sub.1 -C.sub.3 alkyl, halogeno, or nitro; and Z represents S, SO, SO.sub.2 or CH.sub.2.

Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt, or a hydrate thereof, a process for preparing said compound, and a pharmaceutical composition having antiviral activity which comprise said compound.

Abstract: A benzolactam derivative represented by the following formula (I): ##STR1## wherein n represents an integer of from 1 to 3; R.sup.1 represents a straight- or branched-chain alkyl group or an aralkyl group; R.sup.2 represents a straight- or branched-chain alkyl group; R.sup.3 and R.sup.4 independently represent a hydrogen atom or a straight- or branched-chain alkyl group, and when R.sup.3 and R.sup.4 are adjacent each other on the phenyl group, they may be combined to form a cycloalkyl ring together with two carbon atoms of the phenyl group to which R.sup.3 and R.sup.4 bind, and said cycloalkyl ring may optionally have one or more substituents; and a anti-retroviral agent comprising the same as an active ingredient.

Abstract: A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.

Abstract: A novel imidazole derivatives of formula I: ##STR1## wherein R.sup.1 is hydrogen, alkyl, halogen, or optionally substituted aryl; R.sup.2 is alkyl, optionally substituted aryl optionally substituted aralkyl, or optionally substituted hetero ring group; R.sup.3 is hydrogen, alkyl, optionally substituted aryl, optionally substituted aralkyl, or optionally substituted hydroxyalkyl; R.sup.4 is hydrogen, alkyl, halogen, acyl, optionally substituted hydroxyalkyl, optionally esterified or amidated carboxyl group, hydroxy group, aryl or arylthio; X is S, SO, SO.sub.2, CH.sub.2, or Se; n is an integer of 1 to 3, or a pharmaceutically acceptable salt thereof, said derivative having anti-HIV activity and being useful for the treatment of HIV infections.

Abstract: A container body is sealed by means of a lid made of a flexible sheet having an insulative property and an antenna made of an electrically conductive material which is laminated upon the lid. According to this construction, when the container body is exposed to microwaves within a microwave oven, microwave energy is concentrated at a position near the front end of the antenna and the microwave energy is converted into heat energy, whereby the lid is opened by means of the thus converted heat. The lid can thus be precisely partially melted so as to form an opening of a predeterminedly suitable size.

Abstract: A container composed of a plurality of container materials the opposing parts of which are sealed by heat sealing, wherein at least an opening start part of the sealed portion is of a laminated structure consisting of the plurality of container materials and an intermediate material inserted therebetween. The intermediate material and one of the container materials are tightly sealed, and the intermediate material and another of the container materials are sealed easily peelably. The inside end edge of the easily peelable seal portion is positioned more toward the center of the container than the inside end edge of the tight seal portion. At an opening start position, the outside end edge of the easily peelable seal portion is positioned more toward the center of the container than the outside end edge of the tight seal portion, and the intermediate material is provided so as to jut outwwardly of a heat sealing flat portion of a container flange.

Abstract: The whole DNA sequence coding for flagellin of E. coli (hag gene) cloned in phage .lambda. was determined. The hag gene is introduced into pBR322 and the region of the hag gene concerning the antigencity of flagella is lacked, into which linkers are inserted. Where the vector in which foreign DNA is inserted in the linker is introduced in E. coli forming no flagella, the E. coli can form flagella and possesses motility. The flagella comprises flagellin fused with foreign peptide encoded by the foreign DNA. Namely, the foreign peptide is excreted outside of bacteria. This system can be utilized in determination of epitope and preparation of antigen as well as excretion of peptide.

Abstract: A deep-draw-formed vessel which is prepared by deep-draw-forming a laminate comprising a steel or iron foil and a plastic film formed on each surface of the steel or iron foil through a layer of an adhesive having an adhesive force of at least 600 g/15 mm of width and an elastic modulus of 50 to 10,000.A Kg/cm.sup.2 inorganic filler such as titanium dioxide is preferably incorporated in the plastic film so as to improve the deep-drawability.

Abstract: Disclosed is a packaging material which comprises a laminate having an iron foil having a tensile strength (.sigma..sub.B) in the range represented by the following formula:100 kg/mm.sup.2 .gtoreq..sigma..sub.B .gtoreq.30 kg/mm.sup.2and a thickness (T) in the range represented by the following formula:120 .mu.m.gtoreq.T.gtoreq.15 .mu.mand being provided with a surface treatment layer containing metallic tin, metallic chromium or metallic nickel, and an organic resin covering having a total thickness (t) in the range represented by the following formula:T.sup.1/n C/.sigma..sub.B .gtoreq.t.gtoreq.3 .mu.mwherein n is 5.6 and C is 4630.A metal or pigment having an action of improving the processability, an anti-corrosive action and a hiding action is incorporated or contained in the organic resin coating layer. This packaging material is excellent in processability, corrosion resistance, storability, appearance characteristics and safety.

Abstract: There is disclosed a hermetic sealed container filled with a positive pressure generating contents. The container is sealed with a lid comprising a spherical-shaped outwardly protruded panel portion formed with an opening, and a seal tab bonded to the outer surface thereof to cover the opening.

Abstract: Penicillins and cephalosporins can be synthesized by the action of an acylase on a penicillin or cephalosporin nucleus amine as substrate and an ester (I) of the following formula as the acyl source: ##STR1## (wherein RCO is an acyl group in penicillin or cephalosporin side chains;X is a hydrogen atom, lower alkyl group or hydroxy-lower alkyl group;Y is a hydrogen atom or a lower alkyl group; and n is a positive integer).The novel acyl source (I) is also disclosed.