Patents by Inventor Tamio Hara
Tamio Hara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8835636Abstract: A method for producing a hydroxypyrazine derivative represented by formula (I) (wherein R1 represents a halogen atom), the method including reacting a pyrazine derivative represented by formula (III) (wherein R2 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group or a carboxyl group, M represents a cation capable of forming a salt, and n represents a number corresponding with the valence of M) with a halogenating agent. According to the present invention, a hydroxypyrazine derivative that functions as a production intermediate for the dichloropyrazine derivative can be produced efficiently at low cost.Type: GrantFiled: September 25, 2013Date of Patent: September 16, 2014Assignee: Nippon Soda Co., Ltd.Inventors: Tamio Hara, Naoki Norimatsu, Hiroaki Kurushima, Takuya Kano
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Publication number: 20140024832Abstract: A method for producing a hydroxypyrazine derivative represented by formula (I) (wherein R1 represents a halogen atom), the method including reacting a pyrazine derivative represented by formula (III) (wherein R2 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group or a carboxyl group, M represents a cation capable of forming a salt, and n represents a number corresponding with the valence of M) with a halogenating agent. Also, a method for producing a dichloropyrazine derivative represented by formula (II) (wherein R21 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group, a carboxyl group, or a group formed as a result of a change in the functional group of R2 during chlorination), the method including reacting the hydroxypyrazine derivative (I) with a chlorinating agent.Type: ApplicationFiled: September 25, 2013Publication date: January 23, 2014Applicant: NIPPON SODA CO., LTD.Inventors: Tamio HARA, Naoki NORIMATSU, Hiroaki KURUSHIMA, Takuya KANO
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Patent number: 8586741Abstract: A method for producing a hydroxypyrazine derivative represented by formula (I) (wherein R1 represents a halogen atom), the method including reacting a pyrazine derivative represented by formula (III) (wherein R2 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group or a carboxyl group, M represents a cation capable of forming a salt, and n represents a number corresponding with the valence of M) with a halogenating agent. Also, a method for producing a dichloropyrazine derivative represented by formula (II) (wherein R21 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group, a carboxyl group, or a group formed as a result of a change in the functional group of R2 during chlorination), the method including reacting the hydroxypyrazine derivative (I) with a chlorinating agent.Type: GrantFiled: January 14, 2010Date of Patent: November 19, 2013Assignee: Nippon Soda Co., Ltd.Inventors: Tamio Hara, Naoki Norimatsu, Hiroaki Kurushima, Takuya Kano
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Publication number: 20110275817Abstract: A method for producing a hydroxypyrazine derivative represented by formula (I) (wherein R1 represents a halogen atom), the method including reacting a pyrazine derivative represented by formula (III) (wherein R2 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group or a carboxyl group, M represents a cation capable of forming a salt, and n represents a number corresponding with the valence of M) with a halogenating agent. Also, a method for producing a dichloropyrazine derivative represented by formula (II) (wherein R21 represents a nitrile group, an N-unsubstituted or N-substituted carbamoyl group, an ester group, a carboxyl group, or a group formed as a result of a change in the functional group of R2 during chlorination), the method including reacting the hydroxypyrazine derivative (I) with a chlorinating agent.Type: ApplicationFiled: January 14, 2010Publication date: November 10, 2011Applicant: Nippon Soda Co., Ltd.Inventors: Tamio Hara, Naoki Norimatsu, Hiroaki Kurushima, Takuya Kano
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Patent number: 6157701Abstract: An X-ray generating apparatus in which X-rays are emitted from laser plasma, the X-ray generating apparatus including a strong magnetic field generating device for generating a magnetic field component substantially parallel with the target surface in the vicinity of the laser plasma. The magnetic field component is arranged to generate a magnetic force which acts directly on charged particles in the laser plasma to bend the tracks of the charged particles, causing the charged particles to be confined in a magnetic field formed by the magnetic field component. The magnetic flux of the strong magnetic field is directed to a direction which is different from the direction in which the laser plasma is generated. An X-ray supply object is disposed in the laser plasma generating direction. Charged particles, liable to be directed to the X-ray supply object, are mainly confined in the strong magnetic field.Type: GrantFiled: June 16, 1997Date of Patent: December 5, 2000Assignees: Shimadzu Corporation, The Institute of Physical and Chemical ResearchInventors: Hideo Hirose, Tamio Hara, Kozo Ando, Yoshinobu Aoyagi
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Patent number: 5991082Abstract: Lens systems are disclosed having multiple focal lines and that are operable to form multiple narrow superimposable focal lines. The focal lines typically have linewidths of .ltoreq. approximately 10 .mu.m, formed from an incident light flux from a laser. The superimposed focal lines can have sufficient energy density to serve as a pumping-laser source for an X-ray laser. The lens systems comprise, axially from the incident light side, a wave-surface splitter and a focusing system. The wave-surface splitter splits the wave surface of the incident light into subfluxes. The focusing system focuses the subfluxes into respective linear focal lines that can be superimposed to form a combined focal line having very high energy density. The wave-surface splitter is preferably a prism having multiple facets with respective prism angles; the focusing system preferably comprises multiple cylindrical lenses each having a generation line perpendicular to the ridge lines separating the facets of the prism.Type: GrantFiled: February 21, 1997Date of Patent: November 23, 1999Assignees: Nikon Corporation, Toyota School Foundation, Institute of Physical and Chemical ResearchInventors: Teruyoshi Tsunashima, Tamio Hara, Kozo Ando
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Patent number: 5887048Abstract: A reflecting mirror of an X-ray reflecting device is produced by a spherical surface machining method, and when the device is used, a desired aspherical reflecting surface can be obtained by elastically deforming the mirror with application of an external force. The device has the mirror 11 and a support member 17. The mirror 11 is made of elastically deformable material. A surface 11a of the mirror 11 is finished by the spherical surface machining method. When the device is used, pressure is applied against a rear surface 11b of the mirror 11 and the mirror 11 is deformed into a desired aspherical shape.Type: GrantFiled: April 28, 1997Date of Patent: March 23, 1999Assignees: Toyota Jidosha Kabushiki Kaisha, Toyota School Foundation, Denso CorporationInventors: Toshio Sata, Tamio Hara, Naohiro Yamaguchi
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Patent number: 5832007Abstract: An X-ray laser generating apparatus comprises a laser oscillator for generating a pulse laser beam, a pulse train converter for converting the pulse laser beam into a pulse train laser beam, an optical device for focusing the pulse train laser beam to a thin line, a target material placed at the laser beam focused position and generating high temperature plasma containing highly charged ions with irradiation of the linearly focused pulse train laser beam, a vacuum chamber for keeping a vicinity of the irradiated region of the target material under a decompressed state, and a pair of X-ray reflecting mirrors positioned on both sides of the target material and on the extended thin line, and at least one of the paired mirrors partially transmits X-ray.Type: GrantFiled: February 20, 1997Date of Patent: November 3, 1998Assignees: Toyota Jidosha Kabushiki Kaisha, Toyota School Foundation, Denso CorporationInventors: Tamio Hara, Naohiro Yamaguchi, Toshio Sata
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Patent number: 5832052Abstract: An X-ray microscope utilizing X-rays radiating from a laser-irradiated target so as to form an X-ray image of a specimen placed in a sample cell, the X-ray microscope includes a target for radiating X-rays when the same is irradiated with a laser beam, a sample cell for housing a specimen, the sample cell provided near the surface of target placed opposite to where the target is irradiated with the laser beam, and a detector for forming an X-ray image of the specimen by X-ray penetration, wherein the target, the sample cell and the detector are unified in a unit. The unit is placed at a place where the laser beam is irradiated to the target. A spacer is provided between the target and the sample cell, wherein the size of the spacer is determined depending on a distance between the specimen and the target. With this construction, this facilitates the fabrication of the unit.Type: GrantFiled: June 24, 1996Date of Patent: November 3, 1998Assignees: Shimadzu Corporation, The Institute of Physical and Chemical ResearchInventors: Hideo Hirose, Kozo Ando, Yoshinobu Aoyagi, Tamio Hara
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Patent number: 5792861Abstract: The present invention provides a process for the production of a 4-substituted azetidinone. The process comprises reacting ##STR1## wherein R represents a hydrogen atom or a protecting group for N, R.sup.1 represents an alkyl which may be a substituent having an unprotected or protected hydroxyl group; and Z represents a leaving group; with ##STR2## wherein R.sup.2 represents hydrogen or alkyl, R.sup.3 and R.sup.4 each represent hydrogen, alkyl, alkenyl, alkynyl, phenyl, cycloalkyl, or naphthyl, or R.sup.3 and R.sup.4, together with the carbon atom to which they are bonded, form a ring system; X and Y each represent oxygen, sulfur or N-r.sup.1, wherein r.sup.1 represents a hydrogen atom or lower alkyl; A, B, D and E each represent nitrogen or C-r.sup.2, wherein r.sup.2 represents hydrogen, halogen, lower alkyl or lower alkoxy, provided that at least two of A, B, D and E are C-r.sup.Type: GrantFiled: November 4, 1996Date of Patent: August 11, 1998Assignees: Tanabe Seiyaku Co., Ltd., Nippon Soda Co., Ltd.Inventors: Tamio Hara, Yuuki Nakagawa, Nobuo Matsui, Shigemi Suga
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Patent number: 5731431Abstract: A process for preparing 4-substituted azetidinone derivatives of the formula: ##STR1## wherein R is hydrogen or an easily removable protecting group; R.sup.1 is alkyl which can be substituted by hydroxy which can be protected or halogen; R.sup.2 is hydrogen or alkyl; R.sup.3 is alkyl, trialkylsilyl, phenyl which can be substituted by alkyl, alkoxy, nitro or halogen, cycloalkyl, naphthyl, anthracenyl, fluorenyl, benzothiazolyl or naphthalimidyl; and R.sup.4 is an electron withdrawing group or can form a ring together with R.sup.3, which comprises reacting an azetidinone derivative of the formula: ##STR2## wherein R and R.sup.1 are as defined above, and Z is a leaving group, and an imide compound of the formula: ##STR3## wherein R.sup.2, R.sup.3 and R.sup.4 are as defined above, in the presence of a titanium compound of the formula:Ti(Cl).sub.n (OR.sup.5).sub.mwherein R.sup.5 is lower alkyl, n and m are respectively an integer from 0 to 4, provided that n plus m always makes 4, and a base.Type: GrantFiled: June 10, 1996Date of Patent: March 24, 1998Assignee: Nippon Soda Co., Ltd.Inventors: Yuuki Nakagawa, Kiyohito Imai, Tamio Hara
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Patent number: 5680429Abstract: An X-ray generating apparatus generates X-rays from plasma formed by irradiating a laser beam to a target. The apparatus includes an X-ray transmitting film disposed at at least one side of the target with a predetermined gap provided therebetween. The X-ray transmitting film has a thickness such that the film is not broken due to an action in the X-ray generating process. The X-rays are taken out through the X-ray transmitting film. An X-ray microscope can employ such an X-ray generating apparatus, with the X-rays from the apparatus being guided to the sample, with the sample to be observed being disposed in the vicinity of the X-ray transmitting film, and with a detecting device for detecting an X-ray image formed by X-rays transmitted through the sample.Type: GrantFiled: January 17, 1996Date of Patent: October 21, 1997Assignees: Shimadzu Corporation, The Institute of Physical & Chemical ResearchInventors: Hideo Hirose, Tamio Hara, Kozo Ando, Yoshinobu Aoyagi
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Patent number: 5326981Abstract: In an electron beam excited ion irradiation apparatus which irradiates ions to a material, an electrical discharge changes an inert gas into a plasma. Electrons are drawn from this plasma and are made into electron beams. The electron beams are passed through an active gas to create ion. When the ion is irradiated to a material, electron components of the electron beams, which are irradiated vertically to a surface of the material are changed their irradiation direction. Control of the range of electron beam irradiation is performed by a magnetic filed formed so as to surround the ion beams.Type: GrantFiled: September 25, 1992Date of Patent: July 5, 1994Assignees: Kawasaki Jukogyo Kabushiki Kaisha, Riken Institute of Physical and Chemical ResearchInventors: Tamio Hara, Manabu Hamagaki, Katsunobu Aoyagi, Takeshi Yamada, Makoto Ryoji, Masakuni Tokai, Yosuke Kajiyama
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Patent number: 4749912Abstract: An ion-producing apparatus comprises an electron-producing vessel having an electron-producing chamber, an ion-producing vessel having an ion-producing chamber communicating with the electron-producing chamber, a cathode provided at one end of the electron-producing vessel, an accelerating electrode provided within the ion-producing chamber, for allowing passage of electrons, an anode provided between the cathode and the accelerating electrode, and a power supply circuit for providing a potential difference between the cathode and the anode, thereby to produce electrons in the gap between the cathode and the anode. A vacuum pump is provided for evacuating gas from the ion-producing chamber. A partition is provided within the electron-producing vessel, between the cathode and the anode to divide the electron-producing vessel into a cathode-side chamber and an anode-side chamber, and hinders a gas flow from the cathode-side chamber to the anode-side chamber to apply a pressure difference between both chambers.Type: GrantFiled: May 27, 1987Date of Patent: June 7, 1988Assignees: Rikagaku Kenkyusho, Tokyo Electron LimitedInventors: Tamio Hara, Manabu Hamagaki, Yoshinobu Aoyagi, Susumu Namba, Nobuo Ishii, Naoki Takayama, Kohei Kawamura
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Patent number: 4749910Abstract: An electron beam-excited ion beam source having a plasma region, an accelerating cathode, an electron beam accelerating region, an accelerating anode, an ion producing region and a target cathode in this order, and further comprising means for applying a negative electric potential to the target cathode as against the accelerating cathode and an ion extracting electrode for extracting positive ions or negative ions produced in the ion producing region whereby a high current ion beam can be obtained in a low input power.Type: GrantFiled: May 28, 1986Date of Patent: June 7, 1988Assignee: Rikagaku KenkyushoInventors: Tamio Hara, Manabu Hamagaki, Yoshinobu Aoyagi, Susumu Namba