Patents by Inventor Tamir S. Levi

Tamir S. Levi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220370198
    Abstract: An assembly and associated method for a commissure of a prosthetic heart valve is disclosed. As one example, a method includes forming a plurality of commissures with a plurality of leaflets of a prosthetic heart valve, wherein each commissure is formed by: folding each commissure tab of each leaflet into a series of overlapping layers, each folded commissure tab arranged outward of, in a lateral direction, a portion of a body of the leaflet that is directly connected to the commissure tab; pairing each folded commissure tab of each leaflet with a folded commissure tab of another leaflet; and securing at least a portion of the series of overlapping layers of each folded commissure tab in its folded configuration.
    Type: Application
    Filed: August 4, 2022
    Publication date: November 24, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Noam Nir, Elena Sherman, Michael Bukin, Tamir S. Levi, Ziv Yohanan, David Maimon
  • Publication number: 20220346949
    Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.
    Type: Application
    Filed: July 12, 2022
    Publication date: November 3, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Dikla Kersh, Michael Bukin, Tamir S. Levi, Noam Nir
  • Patent number: 11484406
    Abstract: Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. The valve can include a valvular structure including two or more leaflets, each of the two or more leaflets having a leaflet inflow edge positioned at least partially outside of the frame and a leaflet outflow edge positioned within the frame, wherein at least a portion of each of the leaflet inflow edges is unsupported by the frame.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: November 1, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Tamir S. Levi
  • Publication number: 20220331096
    Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
    Type: Application
    Filed: April 22, 2022
    Publication date: October 20, 2022
    Inventors: Ziv Yohanan, Tamir S. Levi, Netanel Benichou, Michael Bukin, Nikolay Gurovich, Elena Sherman
  • Publication number: 20220323210
    Abstract: Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.
    Type: Application
    Filed: June 28, 2022
    Publication date: October 13, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Noam Nir, Elena Sherman, Tamir S. Levi, Michael Bukin
  • Patent number: 11446141
    Abstract: An implantable prosthetic device can include a frame that is radially expandable and compressible between a radially compressed configuration and a radially expanded configuration. The frame can have a first set of a plurality of struts extending in a first direction, and a second set of a plurality of struts extending in a second direction, and each strut of the first set of struts can be pivotably connected to at least one strut of the second set of struts. Each strut can be curved helically with respect to a first, longitudinal axis of the frame, and each strut can be curved with respect to a second axis that is perpendicular to the first, longitudinal axis of the frame.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: September 20, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Anatoly Dvorsky, Tamir S. Levi, Yair A. Neumann, Noa Axelrod Manela, Eitan Atias, Oren Cohen, Elazar Levi Schwarcz, Ofir Witzman, Noam Miller, Boaz Manash, Danny M. Garmahi
  • Publication number: 20220287834
    Abstract: A belt for an implantable prosthetic device can include an annular body including a plurality of alternating peaks and valleys and a plurality of frangible members extending between at least one of adjacent peaks and adjacent valleys. The annular body can be radially expandable from a radially compressed configuration to a first diameter upon application of a radially outwardly directed force via an expandable implantable prosthetic device. A first frangible member of the plurality of frangible members can be configured to break when the radially outwardly directed force exceeds a first predetermined threshold to allow radial expansion of the annular body to a second diameter.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 15, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tal Reich, Noam Nir, Ziv Yohanan, Tamir S. Levi, Michael Bukin
  • Patent number: 11432923
    Abstract: Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.
    Type: Grant
    Filed: August 24, 2018
    Date of Patent: September 6, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventor: Tamir S. Levi
  • Publication number: 20220273428
    Abstract: Disclosed herein are embodiments of a balloon shaped to have one or more enlarged regions to selectively increase expansion forces on an implant. For example, the balloon may have a central portion that is enlarged to exert more force on the center of a stent-mounted prosthetic heart valve. This overcomes the stent-mounted prosthetic heart valve's tendency to expand with flared ends. This forms a more cylindrical or barrel shaped stent frame during expansion of the balloon—reducing or eliminating the instance wherein the cylindrical stent frame has flared ends. Alternatively, the balloon may have conical flares placed to cause or enhance flared ends of the cylindrical implant to enhance its anchoring capabilities.
    Type: Application
    Filed: March 14, 2022
    Publication date: September 1, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: David Maimon, Michael R. Bialas, Mindy Lee Ann Black, Tamir S. Levi, Linda Thai, Yidong M. Zhu
  • Publication number: 20220265445
    Abstract: An implantable prosthetic valve comprises an annular frame that is radially expandable from a radially compressed state to a radially expanded state. The frame has an inflow end, an outflow end, and a longitudinal axis extending from the inflow end to the outflow end. The prosthetic valve also comprises a plurality of leaflets positioned to regulate a flow of blood from the inflow end to the outflow end of the frame, and a skirt assembly. The skirt assembly comprises a laminate having a textile layer sandwiched between a first encapsulation layer and a second encapsulation layer. The first and second encapsulation layers are made of an elastomer and the textile layer comprises a first set of yarns and a second set of yarns interwoven with the first set of yarns, wherein the first and second sets of yarns are non-perpendicular and non-parallel to the longitudinal axis.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Inventors: Michael Bukin, Tamir S. Levi
  • Publication number: 20220257367
    Abstract: An implantable prosthetic valve can include a frame movable between a radially compressed and a radially expanded configuration. The frame can include a first strut having a first locking feature disposed on a radially facing inner surface of the strut and a second strut having a second locking feature disposed on a radially facing outer surface of the strut. The first and second locking features can engage each other so as to allow pivoting of the first and second struts relative to one another in a first direction upon radial expansion of the frame and resist pivoting of the first and second struts relative to one another in a second direction to resist radial compression of the frame.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Yair A. Neumann, Oren Cohen, Khen Perlmutter, Eitan Atias, Noam Miller, Eran Goldberg, Anatoly Dvorsky, Tamir S. Levi, Haim Yushtein, Danny M. Garmahi, Ziv Yohanan, Michael Bukin, Noam Nir, Elena Sherman, Gideon Sagi
  • Publication number: 20220257379
    Abstract: The present disclosure relates to devices and methods for measuring expansion diameter, radial force exerted against surrounding tissue, and pressure recovery across prosthetic heart valves, during valve implantation procedures.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Anatoly Dvorsky, Tamir S. Levi
  • Publication number: 20220257128
    Abstract: The present invention relates to devices and methods for measuring physiological parameters, such as flow, pressure, temperature, electric conductivity and/or visual indication of thrombus formation or deposits accumulations, prior to, during and/or after prosthetic heart valve implantation procedures.
    Type: Application
    Filed: April 29, 2022
    Publication date: August 18, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Eran Goldberg, Tamir S. Levi, David Maimon, Oren Cohen, Martyn Rhys Thomas, Tomer Saar, Elazar Levi Schwarcz
  • Publication number: 20220241070
    Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising a plurality of circumferentially extending rows of angled struts, including first, second, and third rows of angled struts forming rows of diamond-shaped cells, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is disposed between the frame and the cusp edge portions, the skirt being sutured to selected struts of the frame along diagonal paths extending from an inflow end portion toward an outflow end portion. Each diagonal path along which the skirt is sutured to the frame extends along the first, second, and third rows of angled struts.
    Type: Application
    Filed: April 13, 2022
    Publication date: August 4, 2022
    Inventors: Nikolay Gurovich, Michael Bukin, Elena Sherman, Tamir S. Levi, Ziv Yohanan, Gil Senesh, Dikla Kersh, Alexey Tsypenyuk, Waina Michelle Chu, Alexander Barash
  • Publication number: 20220241071
    Abstract: A system can include a delivery catheter comprising a balloon and an implantable prosthetic heart valve. The prosthetic valve can have a plastically expandable and compressible unitary frame comprising first, second, and third rows of angled struts that define two circumferentially extending rows of diamond-shaped cells that extend continuously around the frame, and a valvular structure comprising a plurality of leaflets. A cusp edge portion of each leaflet is connected to the frame by a skirt that is connected to and disposed between the frame and the cusp edge portions of the leaflets, the skirt being connected to consecutive struts in the first, second, and third rows of struts with sutures. The compressed prosthetic heart valve can be mounted around the balloon and radially expanded to the expanded configuration with the balloon inside a patient's body.
    Type: Application
    Filed: April 18, 2022
    Publication date: August 4, 2022
    Inventors: Nikolay Gurovich, Michael Bukin, Elena Sherman, Tamir S. Levi, Ziv Yohanan, Gil Senesh, Dikla Kersh, Alexey Tsypenyuk, Waina Michelle Chu, Alexander Barash
  • Patent number: 11399932
    Abstract: A prosthetic valve assembly includes a radially expandable and compressible annular frame. The frame includes a plurality of interconnected struts, which include a plurality of inner struts and a plurality of outer struts. The inner struts overlap adjacent outer struts at a plurality of pivot joints. Radial expansion or compression of the annular frame causes the inner struts to pivot relative to the outer struts at the pivot joints. The assembly also includes a valvular structure having a plurality of leaflets, each leaflet having a cusp edge portion. The assembly further includes one or more leaflet-supporting cords, each having a plurality of anchoring portions and a plurality of suspended portions, each suspended portion extending between two adjacent anchoring portions. The anchoring portions are affixed to respective anchoring features of the frame adjacent the pivot joints. The cusp edge portions of the leaflets are connected to the suspended portions.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: August 2, 2022
    Assignee: Edwards Lifesciences Corporation
    Inventors: Dikla Kersh, Michael Bukin, Tamir S. Levi, Noam Nir
  • Publication number: 20220233305
    Abstract: A method of implanting a prosthetic heart valve within a patient can comprise inserting a distal end portion of a delivery apparatus and a prosthetic heart valve into the patient and advancing the prosthetic heart valve to a deployment location within the heart of the patient and inflating one or more of a plurality of differently-sized balloons in a balloon-assembly on the distal end portion of the delivery apparatus. The prosthetic heart valve can be mounted on the balloon assembly in a crimped state and the inflating of the one or more of the plurality of differently-sized balloons can expand the prosthetic heart valve from the crimped state to a radially expanded state having a non-cylindrical shape.
    Type: Application
    Filed: April 8, 2022
    Publication date: July 28, 2022
    Inventors: Ziv Yohanan, Tamir S. Levi, Netanel Benichou, Michael Bukin, Nikolay Gurovich, Elena Sherman
  • Publication number: 20220226111
    Abstract: Embodiments of a radially collapsible and expandable prosthetic heart valve are disclosed. A valve frame can have a tapered profile when mounted on a delivery shaft, with an inflow end portion having a smaller diameter than an outflow end portion. The valve can comprise generally V-shaped leaflets, reducing material within the inflow end of the frame. An outer skirt can be secured to the outside of the inflow end portion of the frame, the outer skirt having longitudinal slack when the valve is expanded and lying flat against the frame when the valve is collapsed. A diagonally woven inner skirt can elongate axially with the frame. Side tabs of adjacent leaflets can extend through and be secured to window frame portions of the frame to form commissures. The window frame portions can be depressed radially inward relative to surrounding frame portions when the valve is crimped onto a delivery shaft.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 21, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventors: Tamir S. Levi, Son V. Nguyen, Netanel Benichou, David Maimon, Ziv Yohanan, Nikolay Gurovich, Bella Felsen, Larisa Dadonkina, Ron Sharoni, Elena Sherman
  • Publication number: 20220218470
    Abstract: Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.
    Type: Application
    Filed: March 28, 2022
    Publication date: July 14, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventor: Tamir S. Levi
  • Publication number: 20220218477
    Abstract: Prosthetic devices and frames for implantation at a cardiac valve annulus are provided that include an annular frame (having an inflow end and an outflow end) and a plurality of axial frame members that bridge two circumferentially extending rows of angled struts. The axial frame members can include a plurality of axially extending leaflet attachment members and a plurality of axial struts in a 1:1 ratio. Along each of the two rows, the frame can have at least three angled struts between adjacent axial frame members.
    Type: Application
    Filed: March 31, 2022
    Publication date: July 14, 2022
    Applicant: Edwards Lifesciences Corporation
    Inventor: Tamir S. Levi