Patents by Inventor Tamir Tuller

Tamir Tuller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11795440
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 5, 2021
    Date of Patent: October 24, 2023
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • METHOD AND SYSTEM FOR DESIGNING POLYNUCLEOTIDE SEQUENCES AND POLYNUCLEOTIDE SEQUENCES OBTAINED THEREBY
    Publication number: 20230230658
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Application
    Filed: March 20, 2023
    Publication date: July 20, 2023
    Applicant: Ramot at Tel-Aviv University Ltd.
    Inventors: Tamir TULLER, Hadas ZUR
  • MOLECULES AND METHODS FOR INCREASED TRANSLATION
    Publication number: 20230183716
    Abstract: Nucleic acid molecule comprising a coding sequence and a region of increased folding energy upstream of a stop codon are provided. Expression vectors and cells comprising the nucleic acid molecule are also provided. Methods for optimizing a coding sequence comprising increasing folding energy in a region upstream of the stop codon are also provided.
    Type: Application
    Filed: July 21, 2022
    Publication date: June 15, 2023
    Inventors: Tamir TULLER, Michael PEERI
  • CHIMERIC POLYPEPTIDES AND METHODS OF PREPARING SAME
    Publication number: 20230167476
    Abstract: The present invention is directed to a chimeric polypeptide including a polypeptide of interest N-terminal to an essential protein of a target cell. Further provided is a polynucleotide encoding the chimeric polypeptide, a method of producing thereof, and a method for producing a protein of interest. The chimeric polypeptide of the invention improves the genetic stability of the polypeptide of interest ensuring its expression over time.
    Type: Application
    Filed: April 22, 2021
    Publication date: June 1, 2023
    Inventors: Tamir TULLER, Matan ARBEL, Itamar MENUHIN, Itai KATZIR, Shaked BERGMAN, Doron NAKI
  • MODIFIED GENOMES AND USE THEREOF
    Publication number: 20230107824
    Abstract: Modified genomes of an organism comprising at least one coding sequence comprising at least one mutation, wherein the mutation generates an underrepresented sequence that is underrepresented in the unmodified genome of the organism are provided. Organism and cells comprising the modified genomes of the invention, pharmaceutical compositions comprising the organisms and cells of the invention, as well as methods of making the modified genomes are also provided.
    Type: Application
    Filed: October 6, 2022
    Publication date: April 6, 2023
    Inventors: Tamir TULLER, Yoram ZARAI, Modi ROOPIN, Zohar ZAFRIR
  • Method and system for designing polynucleotide sequences and polynucleotide sequences obtained thereby
    Patent number: 11610650
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: March 21, 2023
    Assignee: Ramot at Tel-Aviv University Ltd.
    Inventors: Tamir Tuller, Hadas Zur
  • RIBOSOME TERMINATION STRUCTURES AND USE THEREOF
    Publication number: 20220396801
    Abstract: Nucleic acid molecule and vectors comprising regions of high or low folding energy are provided. Methods of producing coding sequences optimized for protein expression comprising introducing a mutation that increases or decreased folding energy are also provided.
    Type: Application
    Filed: July 21, 2022
    Publication date: December 15, 2022
    Inventors: Tamir TULLER, Michael PEERI, Yonatan CHEMLA, Lital ALFONTA
  • METHODS FOR MODIFYING TRANSLATION
    Publication number: 20220162595
    Abstract: Nucleic acid molecules comprising a mutation that mutation modulates the interaction strength of the nucleic acid molecule to a 16S ribosomal RNA are provided. Methods of improving the translation process of a nucleic acid molecule and producing a nucleic acid molecule optimized for translation, as well as cells comprising the nucleic acid molecules are also provided.
    Type: Application
    Filed: September 28, 2021
    Publication date: May 26, 2022
    Inventors: Tamir TULLER, Shir BAHIRI, Boaz APT
  • METHODS FOR MODIFYING THE GROWTH RATE OF A CELL
    Publication number: 20220098598
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Application
    Filed: December 16, 2021
    Publication date: March 31, 2022
    Inventors: Tamir TULLER, Hadas ZUR, Rachel COHEN-KUPIEC
  • METHODS FOR DETERMINING INCREASED RISK OF CANCER DEVELOPMENT AND TREATING THE SAME
    Publication number: 20220042010
    Abstract: The present invention is directed to a method for treating cancer in a subject determined as having the presence of a G600>A substitution, a C601>T substitution, or both, in the B cell lymphoma 2 (BCL2) gene of a cell.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 10, 2022
    Inventors: Tamir TULLER, Ofek SCHNITZER, Hadas ZUR, Zohar ZAFRIR
  • Methods for modifying the growth rate of a cell
    Patent number: 11236344
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 1, 2022
    Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
    Inventors: Tamir Tuller, Hadas Zur, Rachel Cohen-Kupiec
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20220010287
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 5, 2021
    Publication date: January 13, 2022
    Applicants: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
  • Attenuated virus mutated at sites of evolutionarily conserved RNA structure
    Patent number: 11111481
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Grant
    Filed: September 29, 2016
    Date of Patent: September 7, 2021
    Assignees: RAMOT AT TEL-AVIV UNIVERSITY LTD., YEDA RESEARCH AND DEVELOPMENT CO. LTD., SYNVACCINE LTD.
    Inventors: Tamir Tuller, Eli Goz, Shimshi Atar, Hadas Zur
  • VIRAL SYNTHETIC NUCLEIC ACID SEQUENCES AND USE THEREOF
    Publication number: 20190359990
    Abstract: Nucleic acid molecules comprising a coding sequence with at least one codon substituted to a synonymous codon, a modified form of a virus comprising the nucleic acid molecules of the invention, and methods for producing these nucleic acid molecules, and viruses, are provided.
    Type: Application
    Filed: January 25, 2018
    Publication date: November 28, 2019
    Inventors: Tamir TULLER, Eli GOZ, Oriah MIODUSER, Alon DIAMENT
  • METHODS FOR MODIFYING THE GROWTH RATE OF A CELL
    Publication number: 20180334679
    Abstract: Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
    Type: Application
    Filed: May 21, 2018
    Publication date: November 22, 2018
    Inventors: Tamir Tuller, Hadas Zur, Rachel Cohen-Kupiec
  • ATTENUATED VIRUS MUTATED AT SITES OF EVOLUTIONARILY CONSERVED RNA STRUCTURE
    Publication number: 20180273911
    Abstract: Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
    Type: Application
    Filed: September 29, 2016
    Publication date: September 27, 2018
    Inventors: Tamir TULLER, Eli GOZ, Shimshi ATAR, Hadas ZUR
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20160152991
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: February 10, 2016
    Publication date: June 2, 2016
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak PILPEL, Tamir TULLER, Sivan NAVON, Menachem RUBINSTEIN
  • Recombinant protein production in heterologous systems
    Patent number: 9267142
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Grant
    Filed: January 25, 2011
    Date of Patent: February 23, 2016
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein
  • METHOD AND SYSTEM FOR DESIGNING POLYNUCLEOTIDE SEQUENCES AND POLYNUCLEOTIDE SEQUENCES OBTAINED THEREBY
    Publication number: 20150347677
    Abstract: Methods of designing a polynucleotide sequence for expressing a polypeptide-of-interest in a cell are provided. Also provided are artificial transcript sequences generated according to the present teachings. Further provided are methods of estimating the adaptiveness of a transcript sequence encoding a polypeptide-of-interest to a gene expression machinery in a cell.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 3, 2015
    Inventors: Tamir Tuller, Hadas Zur
  • RECOMBINANT PROTEIN PRODUCTION IN HETEROLOGOUS SYSTEMS
    Publication number: 20120329091
    Abstract: Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
    Type: Application
    Filed: January 25, 2011
    Publication date: December 27, 2012
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Yitzhak Pilpel, Tamir Tuller, Sivan Navon, Menachem Rubinstein