Abstract: An adjustment system for an Optical Coherence Tomography (OCT) imaging system includes an OCT light source; a beam splitter, splitting the OCT light beam into an imaging beam to an imaging arm, and a reference beam to a reference arm; a probe, guiding the imaging beam onto a target and receiving a returned imaging beam from the target; the beam splitter generating an interference beam from the returned imaging beam and a returned reference beam from the reference arm; an imaging detector, detecting the interference beam; an imaging processor, generating an OCT image from the detected interference beam; and an adjustment device, removably coupled to the probe, the adjustment device comprising the target attached to a distal region of a target holder at a working distance from a distal end of the imaging probe, wherein an optical length of the reference arm is adjustable to improve a calibration of the OCT image.

Abstract: An ophthalmic surgical microscope includes a beam coupler positioned along an optical path of the surgical microscope between a first eyepiece and magnifying/focusing optics, the beam coupler operable to direct the OCT imaging beam along a first portion of the optical path of the surgical microscope between the beam coupler and a patient's eye (an OCT image being generated based on a reflected portion of the OCT imaging beam). The surgical microscope additionally includes a real-time data projection unit operable to project the OCT image generated by the OCT system and a beam splitter positioned along the optical path of the surgical microscope between a second eyepiece and the magnifying/focusing optics. The beam splitter is operable to direct the projected OCT image along a second portion of the optical path of the surgical microscope between the beam splitter and the second eyepiece such that the projected OCT image is viewable through the second eyepiece.

Abstract: Ophthalmic surgical devices, systems, and methods for automatically controlling the injection or extraction of viscous fluids from a patient's eye are provided. A syringe pump connected with an actuation line and a powered syringe provides pressures for viscous fluid injection or extraction in a vitreous chamber of the eye. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the injection or extraction of the viscous fluid in response to the detected IOP, such as by controlling the syringe pump. The controller may determine whether the IOP is above an upper threshold or below a lower threshold and may control the syringe pump to regulate the injection or extraction of viscous fluid to maintain the IOP between the upper and the lower thresholds.

Abstract: Ophthalmic surgical devices, systems, and methods for regulating aspiration from a patient's eye are provided. A vacuum pump in fluid communication with an aspiration line provides fluid aspiration from a vitreous chamber of the eye through the aspiration line. A sensor disposed adjacent to or inside the eye determines sensor data relating to an intraocular pressure (IOP). The controller receives the sensor data and regulates the aspiration in response to changes in the TOP, such as by controlling the vacuum pump. The controller may determine whether a fluid infusion to the vitreous chamber through an infusion line is below a maximum infusion level, regulate the infusion in response to the TOP being below a threshold value and the infusion being below the maximum infusion level, and regulate the aspiration in response to the TOP being below the threshold value and the infusion being at or above the maximum infusion level.

Abstract: An ophthalmic surgical system includes an imaging unit configured to generate a fundus image of an eye and a depth imaging system configured to generate a depth-resolved image of the eye.

Abstract: A device for removing a tissue from an eye of a patient is disclosed, comprising a housing, a cutter, and an actuator. The cutter comprises an outer cutting tube coupled to the housing, an outer port formed in the outer cutting tube, an inner cutting tube slidable along the longitudinal axis within the outer cutting tube between a retracted position proximal to the outer port and an extended position distal to the outer port, and a tissue sensor positioned on the cutter and configured to measure a characteristic of the tissue received within the outer port to identify when nontarget tissue enters the outer port. The actuator within the housing is configured to reciprocate the inner cutting member between the retracted position and the extended position to open and close the outer port and cut the tissue.

Abstract: An OCT tracking system includes an imaging unit operable to generate a fundus image of a patient's eye and a tracking system operable to process the fundus image to determine a location of a surgical instrument inserted into the patient's eye. The OCT tracking system further includes an OCT system including an OCT light source operable to generate an OCT imaging beam and a beam scanner. Based at least in part on the determined location of the surgical instrument, the beam scanner directs the OCT imaging beam to a particular region within the patient's eye, the particular region within the patient's eye including the determined location of the surgical instrument inserted into the patient's eye.

Abstract: An ophthalmic surgical microscope includes a beam coupler positioned along an optical path of the surgical microscope between a first eyepiece and magnifying/focusing optics, the beam coupler operable to direct the OCT imaging beam along a first portion of the optical path of the surgical microscope between the beam coupler and a patient's eye (an OCT image being generated based on a reflected portion of the OCT imaging beam). The surgical microscope additionally includes a real-time data projection unit operable to project the OCT image generated by the OCT system and a beam splitter positioned along the optical path of the surgical microscope between a second eyepiece and the magnifying/focusing optics. The beam splitter is operable to direct the projected OCT image along a second portion of the optical path of the surgical microscope between the beam splitter and the second eyepiece such that the projected OCT image is viewable through the second eyepiece.

Abstract: A surgical imaging system can comprise a light source, configured to generate an imaging light beam; a beam guidance system, configured to guide the imaging light beam from the light source; a beam scanner, configured to receive the imaging light from the beam guidance system, and to generate a scanned imaging light beam; a beam coupler, configured to redirect the scanned imaging light beam; and a wide field of view (WFOV) lens, configured to guide the redirected scanned imaging light beam into a target region of a procedure eye.

Abstract: An OCT tracking system includes an imaging unit operable to generate a fundus image of a patient's eye and a tracking system operable to process the fundus image to determine a location of a surgical instrument inserted into the patient's eye. The OCT tracking system further includes an OCT system including an OCT light source operable to generate an OCT imaging beam and a beam scanner. Based at least in part on the determined location of the surgical instrument, the beam scanner directs the OCT imaging beam to a particular region within the patient's eye, the particular region within the patient's eye including the determined location of the surgical instrument inserted into the patient's eye.

Abstract: An indirect contact lens is mechanically coupled to a surgical microscope during ophthalmic surgery, such as vitreoretinal surgery. The indirect contact lens rests on a cornea of an eye of a patient during the surgery but is supported by a surgical microscope attachment having multiple degrees of freedom to accommodate small movements of the eye while remaining aligned to an optical axis of the surgical microscope.

Abstract: A surgical probe can include an outer cannula; an inner cannula, rotatably disposed inside the outer cannula; a rotational scanner, disposed at an end of the inner cannula and configured to receive a light beam from a delivery fiber and to scan the light beam along a loop; and an anamorphic optical element, disposed at an end of the outer cannula and configured to receive the light beam scanned along the loop and to output the light beam along an anisotropically compressed loop. A corresponding method can include providing a light beam by a light source; coupling the light beam to a rotational scanner at an end of an inner cannula; scanning the light beam by the rotational scanner along a loop; and receiving the light beam scanned along the loop by an anamorphic optical element and outputting the light beam along an anisotropically compressed loop to a target.

Abstract: Apparatuses, systems, and methods for treating tissue abnormalities are disclosed. The tissue may be visualized for determining a presence of one or more abnormalities contained therein. Imaging data obtained by visualization may be used to determine the presence of one or more abnormalities. Each of the detected abnormalities may be identified and a treatment plan developed for treating the abnormalities. Treatment may be delivered to the abnormalities according to the treatment plan.

Abstract: A method of making an optical surgical probe includes providing and heating a substrate; melting a piece of glass on the heated substrate; immersing a ball lens into the molten piece of glass; heating a molding pin having a concave prism end; wetting the concave prism end of the molding pin with a molten glass drop; inserting the molding pin into the molten glass aligned with the ball lens; sliding a cannula along an axis of the molding pin toward the substrate to create a cannula/glass-optical-element/ball lens probe-assembly; cooling the probe-assembly; and extracting the probe-assembly.

Abstract: Devices, systems, and methods for visualizing moving tissue with strobed light are provided. A surgical system includes a surgical device configured to operate on anatomy at a first frequency such that the anatomy moves at the first frequency when the surgical device is in contact therewith; and a light source configured to provide pulses of light at a second frequency to illuminate the moving anatomy; wherein the second frequency is different than the first frequency. A method of treating an ophthalmic condition includes operating a surgical device at a first frequency such that anatomy moves at the first frequency when the surgical device is contacted therewith; and controlling a light source to provide pulses of light at a second frequency to illuminate the moving anatomy; wherein the second frequency is different than the first frequency. An ophthalmic surgical system includes a cutting probe, a strobed light source, and a computing device.

Abstract: A surgical probe (e.g., for treating an eye of a patient) includes a body, a cutting element extending distally from the body including a sleeve member comprising a port at an end, and an inner member disposed within the sleeve member, the inner member being movable (e.g., axially) with respect to the sleeve member to open and close the port. The probe further includes an illumination element disposed within the sleeve member, the illumination element configured to project light out of the port.

Abstract: Devices, systems, and methods for glare reduction in surgical microscopy are provided. A method of operating a surgical microscope may include: receiving light reflected from the surgical field at an image sensor; processing the received light to generate image data; identifying portions of the image data representative of glare; and controlling an optical element to limit the transmission of light associated with the glare. A surgical microscope may include: an image sensor configured to receive light reflected from the surgical field, a computing device, and an optical element. The computing device may be configured to: identify portions of the light received at the image sensor associated with glare and generate a control signal to limit the transmission of the light associated with the glare. The optical element may be configured to selectively limit the transmission of the light associated with the glare in response to the control signal.

Abstract: An optical light scanning probe is presented, the probe comprising a handle, shaped for grasping by a user; a cannula, protruding from a distal portion of the handle with an outer diameter smaller than 20 gauge; an optical fiber with a distal fiber-portion off a probe-axis, configured to receive a light from a light-source at a proximal fiber-portion, and to emit the received light at the distal fiber-portion; a fixed beam forming unit, disposed at a distal portion of the cannula, configured to receive the light from the distal fiber-portion, and to deflect the received light toward a target region; and a fiber actuator, housed at least partially in the handle, configured to move the distal fiber-portion to scan the deflected light along a scanning curve in the target region.

Abstract: A surgical imaging system can comprise a light source, configured to generate an imaging light beam; a beam guidance system, configured to guide the imaging light beam from the light source; a beam scanner, configured to receive the imaging light from the beam guidance system, and to generate a scanned imaging light beam; a beam coupler, configured to redirect the scanned imaging light beam; and a wide field of view (WFOV) lens, configured to guide the redirected scanned imaging light beam into a target region of a procedure eye.

Abstract: A device for removing a tissue from an eye of a patient is disclosed, comprising a housing, a cutter, and an actuator. The cutter comprises an outer cutting tube coupled to the housing, an outer port formed in the outer cutting tube, an inner cutting tube slidable along the longitudinal axis within the outer cutting tube between a retracted position proximal to the outer port and an extended position distal to the outer port, and a tissue sensor positioned on the cutter and configured to measure a characteristic of the tissue received within the outer port to identify when nontarget tissue enters the outer port. The actuator within the housing is configured to reciprocate the inner cutting member between the retracted position and the extended position to open and close the outer port and cut the tissue.