Abstract: A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.

Abstract: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with high affinity (KD), capable of blocking hIL-4 and hIL-13 activity.

Abstract: An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4R?) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.

Abstract: A system, method and program product for designing integrated circuits. A design of an integrated circuit (IC) is analyzed to identify the longest path between each pair of registers. A crosstalk overhead is calculated for each identified longest path using a stochastic model. The crosstalk overhead of each longest path is added to selected path delays as an incremental port of register set up time. Any path wherein the sum of the path delay and crosstalk overhead exceeds a maximum accepted delay, i.e., where slack is less than or equal to zero is redesigned and the IC is then, placed and wired. The stochastic model may be a tree-like structure derived from several completed integrated circuit (IC) designs, in particular from cell placement and wiring for the completed IC. The tree-like stochastic model corresponds crosstalk delays to technology wire factors.

Abstract: A system, method and program for hierarchically designing integrated circuits(ICs). Potential sources of crosstalk are identified in the hierachical design and prior to and during placement and wiring while maintaining the hierachical structure. Blocks are placed and analyzed to determine if all blocks are well behaved and where necessary selectively re-organized to be well behaved. Blockages are inserted blocks to restrict top level wiring to avoid crosstalk. Orthogonal restrictions are placed on top level wiring as well as on top level wire lengths.