Abstract: A freeze-dried monoclonal antibody preparation is prepared by adding to a solution of the monoclonal antibody gelatin or carboxylic acid or its salt, to prevent denaturation of the monoclonal antibodies during freeze-drying. Freeze-dried monoclonal antibody preparations having stablized antigen-binding activity result and may be used as an adminiculum for immunoauxotherapy for prophylaxis and treatment of bacterial infectious diseases and viral infectious diseases.

Abstract: The present invention relates to human monoclonal antibodies capable of plurally binding with O-antigens of Pseudomonas aeruginosa, relates to novel parent cell lines for producing human hybridomas derived from human immunoglobulin synthesizing cells, which cell lines themselves incapable of producing human immunoglobulin and capable of fusing with human antibody-producing cells, relates to human-human hybridomas which can secrete monoclonal antibodies capable of binding with at least one of serotypes of Pseudomonas aeruginosa, relates to pharmaceutical compositions for prophylaxis or therapy of Pseudomonas aeruginosa infectious diseases, and relates to prophylactic or therapeutic methods for Pseudomonas aeruginosa infectious diseases.

Abstract: PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudomonas aeruginosa infection.

Abstract: PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudonomas aeruginosa infection.

Abstract: A fuel injection type internal combustion engine provided with a pressure regulator for controlling a constant difference between a pressure of fuel supplied to the injector and a pressure of the intake system at the position where the injector is mounted. A tank is arranged for storing a positive pressure obtained while the engine is operated. A switching valve is arranged for connecting the tank with the pressure regulator when the engine is started when hot. Due to the operation of the regulator for maintaining the constant pressure difference, the pressure of the fuel supplied to the fuel injector is increased, making it difficult for the fuel to vaporize. Thus, preventing a so-called vapor lock.

Abstract: A water jacket in the turbo-charger is positioned at the same level or higher than a water jacket in an engine cylinder head. The turbo-charger cooling water circulation passageway includes a water volume or tank positioned at a level higher than the turbo-charger cooling portion, and the volume or tank is connected to a cooling water reservoir tank via a pressure relief valve which is opened when pressure in the volume or tank exceeds a predetermined value to supply cooling water to the volume or tank.

Abstract: Thermally-denatured DNA MD-011 having an antitumor activity was obtained by heating the substance separated from the disrupted cells of bacteria belonging to genus Mycobacterium.

Abstract: A hot isostatic pressing apparatus including a high pressure container having an opening at least at one end thereof for loading and unloading materials or products being formed. The high pressure container is internally provided with a heat insulator and a heater. A container holding frame has an open space substantially at the center thereof for releasably holding the upper and lower ends of the high pressure container during the hot isostatic pressing stage of the operation. The container holding frame is movably supported at one side thereof on a stationary structure for movements toward and away from the high pressure container.

Abstract: An intake system for an internal combustion engine comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposition to the injection valve and a hollow valve body mounted in the intake pipe movably in an axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The axial movement of the hollow valve body causes the change in the opening area of the valve opening to control an amount of air-fuel mixture charged therethrough into the engine.

Abstract: An intake system for internal combustion engines comprises a throttling system mounted in an intake pipe between a fuel injection valve and an intake manifold, the throttling system including a stationary valve body fixed in the intake pipe in opposed relation with the injection valve and a hollow valve body mounted in the intake pipe for movement in the axial direction of the intake pipe. The hollow valve body has a downwardly converged inner wall surface surrounding the stationary valve body to define therebetween valve opening of variable opening area. The stationary valve body includes a frusto-conical portion and a cylindrical portion, of which lower edge is in the form of sinusoidal wave to cooperate with the hollow valve body in producing the valve opening of gradually increasing opening area.

Abstract: An air flow amount adjusting system produces an air-fuel mixture of a desirable air-fuel ratio by controlling the direction of movement of a bypass valve mounted in an additional air supply pipe adapted to supply additional air into either the intake system or exhaust system of an internal combustion engine in accordance with an output signal produced from a gas sensor mounted in the exhaust system of the engine and indicative of the air-fuel ratio of the mixture supplied to the engine. A two-level mode signal whose threshold corresponds to the desired air-fuel ratio is produced in accordance with the output signal of the gas detector. After the two-level mode signal has changed from one level to the other level, the movement of the bypass valve is stopped for a certain period of time. If desired, the stopping period of the bypass valve may be changed in accordance with the temperature of the engine.

Abstract: An air flow amount adjusting system produces an air-fuel mixture of a desirable air-fuel ratio by controlling the direction of movement of a bypass valve mounted in an additional air supply pipe adapted to supply additional air into either the intake system or exhaust system of an internal combustion engine in accordance with an output signal produced from a gas sensor mounted in the exhaust system of the engine and indicative of the air-fuel ratio of the mixture supplied to the engine. A two-level mode signal whose threshold corresponds to the desired air-fuel ratio is produced in accordance with the output signal of the gas detector. After the two-level mode signal has changed from one level to the other level, the movement of the bypass valve is stopped for a certain period of time. If desired, the stopping period of the bypass valve may be changed in accordance with the temperature of the engine.

Abstract: Additional air is supplied through an additional air passage having a bypass valve into the main air passage of an internal combustion engine downstream of the throttle valve, and the amount of the additional air is controlled in accordance with the opening of the bypass valve. The direction of rotation of a bypass valve driving pulse motor is controlled in accordance with the output signal of an air-fuel mixture ratio sensor mounted in the exhaust system of the engine. Also the rotational speed of the pulse motor is varied in accordance with the operating conditions of the engine during warm-up operation.

Abstract: An additional air supply system for adjusting the air-fuel ratio of a mixture includes the improved control unit for actuating, at two different speeds, a drive motor of a bypass valve disposed in an additional air supply path. The control unit is provided with an air-fuel ratio discriminating circuit for generating high and low level signals by comparing a detected air-fuel ratio with the stoichiometric ratio, and an actuating circuit for producing pulse signals at each instant of inversion of the signal levels of the air-fuel ratio discriminating circuit in such that for a predetermined period from the instant of inversion a high frequency pulse signal is produced and then a low frequency pulse signal is produced for the remaining period until the next inversion.

Abstract: An apparatus for controlling the air-fuel ratio of an air-fuel mixture to be supplied into a combustion chamber of an internal combustion engine comprises a passage bypassing a carburetor and a throttle valve of the engine for supplying an additional air into the engine intake duct downstream of the throttle valve to dilute the air-fuel mixture to an air-fuel ratio most suited for the engine operation. An air valve is provided in the bypass passage to vary the air-flow cross-sectional area of the passage. The opening of the air valve is controlled mainly in accordance with the air-fuel ratio of the mixture as detected by an air-fuel ratio detector in the path of flow of engine exhaust gases. A variable orifice is provided in the bypass passage downstream of the air valve and defined by a valve seat and a needle valve operatively associated therewith to vary the opening area of the orifice.

Abstract: In an air flow control system including a gas sensor for detecting the concentration of a constituent of the exhaust gases from an internal combustion engine, an air passage for supplying additional air into the intake system or exhaust system of the engine, a by-pass valve for varying the passage area of the additional air passage, and means for controlling the opening and closing of the by-pass valve in accordance with the detection signal from the gas sensor whereby the amount of additional air supplied into the intake system or exhaust system of the engine is controlled in accordance with the concentration of the constituent of the exhaust gases, there is further provided an acceleration/deceleration sensor for detecting acceleration or deceleration of the engine, whereby when a transition from the acceleration or deceleration operating condition to the steady-state operating condition is detected, the opening and closing control of the by-pass valve is accomplished in such a manner that the amount of ope

Abstract: An air-fuel ratio controlling system for an internal combustion engine including a control circuit for controlling, in accordance with a detected air-fuel ratio, the operation of a drive motor of a control valve mounted in an additional air supply passage. The control circuit includes a timing pulse generator for generating timing pulses synchronized with a running speed of the engine and thus the control valve is intermittently rotated by a predetermined amount in response to the timing pulses. By increasing the frequency of the timing pulses during the periods of rapid acceleration and deceleration, a response to the change in the engine speed is further improved.

Abstract: An air-fuel ratio adjusting system controls the amount of additional air supply through the bypass passage of the carburetor to ensure optimum engine operation even in a warming up condition of the engine. The air-fuel ratio adjusting system includes an air-fuel ratio sensor disposed in the exhaust manifold, a warm-up sensor for detecting the temperature of engine cooling water or engine block, and a control unit for providing a control signal to a driving motor for the bypass valve. The bypass valve is controlled so that the air-fuel ratio of the mixture becomes the stoichiometric one and at the same time, during the warming up condition, the maximum opening of the bypass valve is limited to a predetermined degree depending on the temperature of the engine.