Patents by Inventor Tangyi ZHOU

Tangyi ZHOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BISPECIFIC CS1-BCMA CAR-T CELL AND APPLICATION THEREOF
    Publication number: 20240082401
    Abstract: The present invention provides a bispecific CS1-BCMA CAR-T cell and an application thereof. Specifically, the present invention provides a bispecific CAR, which comprises CS1 scFv and BCMA scFv, and a 4-1BB co-stimulatory domain and a CD3 activation domain. The bispecific CAR-T cell in the present invention has a significant killing effect on CS1 positive target cells and BCMA positive target cells, and can secrete IFN-? against target cells and significantly inhibit the growth of RPMI8226 xenograft tumor in an in vivo experiment. The present invention further provides a preparation method and an application of the bispecific CAR-T cell.
    Type: Application
    Filed: January 26, 2022
    Publication date: March 14, 2024
    Inventors: Lianjun ZHANG, Heng MEI, Tangyi ZHOU, Xiongbo CHEN, Wei XIONG