Patents by Inventor Tania Cristiano

Tania Cristiano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of ospemifene and fispemifene
    Patent number: 9975832
    Abstract: Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CH2CH2—Y of formula 7, wherein X is a leaving group and Y is the —(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 22, 2018
    Assignee: OLON S.P.A.
    Inventors: Tania Cristiano, Marco Alpegiani
  • PROCESS FOR THE PREPARATION OF OSPEMIFENE AND FISPEMIFENE
    Publication number: 20170342007
    Abstract: Disclosed is a process for the synthesis of the active ingredients ospemifene and fispemifene which comprises reacting phenol 4 with an alkylating agent X—CH2CH2—Y of formula 7, wherein X is a leaving group and Y is the —(OCH2CH2)nOH group wherein n is zero or 1; or X and Y, taken together, represent an oxygen atom; to give ospemifene or fispemifene of formula 8.
    Type: Application
    Filed: December 28, 2015
    Publication date: November 30, 2017
    Inventors: Tania Cristiano, Marco Alpegiani
  • Procedure for the preparation of abiraterone acetate and intermediates thereof
    Patent number: 9630987
    Abstract: Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: April 25, 2017
    Assignee: OLON S.P.A.
    Inventors: Tania Cristiano, Marco Alpegiani
  • PROCEDURE FOR THE PREPARATION OF ABIRATERONE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20170044207
    Abstract: Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale.
    Type: Application
    Filed: October 27, 2016
    Publication date: February 16, 2017
    Inventors: Tania Cristiano, Marco Alpegiani
  • Procedure for the preparation of abiraterone acetate and intermediates thereof
    Patent number: 9556219
    Abstract: Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale. There is also provided a process for the production of abiraterone acetate by acetylation of abiraterone in the absence of bases or acetylation catalysts.
    Type: Grant
    Filed: January 27, 2015
    Date of Patent: January 31, 2017
    Assignee: OLON S.P.A.
    Inventors: Tania Cristiano, Marco Alpegiani
  • PROCEDURE FOR THE PREPARATION OF ABIRATERONE ACETATE AND INTERMEDIATES THEREOF
    Publication number: 20160347786
    Abstract: Disclosed is a process for the preparation of abiraterone and abiraterone acetate with high yields and purity. A key element of the method is the isolation of a crystalline intermediate that makes the process particularly suitable for implementation on an industrial scale. There is also provided a process for the production of abiraterone acetate by acetylation of abiraterone in the absence of bases or acetylation catalysts.
    Type: Application
    Filed: January 27, 2015
    Publication date: December 1, 2016
    Inventors: Tania CRISTIANO, Marco ALPEGIANI
  • Process for the purification of abiraterone acetate
    Patent number: 9340571
    Abstract: The invention relates to a process for the purification of crude abiraterone acetate by treatment with polymer resins in aqueous solvent. The purified product is recovered by simple concentration and filtration.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: May 17, 2016
    Assignee: OLON S.P.A.
    Inventors: Marco Alpegiani, Tania Cristiano, Eugenio Cucchetti
  • Process for the preparation of unsaturated trifluoromethanesulfonate steroid derivatives
    Patent number: 9315541
    Abstract: Disclosed is a method for the conversion of a compound of formula 3 to a compound of formula 4, wherein R is an acetyl group or an alcohol-protecting group. The process involves reacting 3 with a triflating agent in the presence of a nicotinate (3-pyridinecarboxylate) of a C1-C4 alcohol, preferably methyl nicotinate (methyl 3-pyridinecarboxylate) or ethyl nicotinate (ethyl 3-pyridinecarboxylate), to give 4. The method can be conveniently used in a process for the preparation of Abiraterone or Abiraterone acetate.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 19, 2016
    Assignee: OLON S.P.A.
    Inventors: Marco Alpegiani, Tania Cristiano
  • PROCESS FOR THE PURIFICATION OF ABIRATERONE ACETATE
    Publication number: 20160052958
    Abstract: The invention relates to a process for the purification of crude abiraterone acetate by treatment with polymer resins in aqueous solvent. The purified product is recovered by simple concentration and filtration.
    Type: Application
    Filed: October 21, 2013
    Publication date: February 25, 2016
    Inventors: Marco Alpegiani, Tania Cristiano, Eugenio Cucchetti
  • PROCESS FOR THE PREPARATION OF UNSATURATED TRIFLUOROMETHANESULFONATE STEROID DERIVATIVES
    Publication number: 20150337007
    Abstract: Disclosed is a method for the conversion of a compound of formula 3 to a compound of formula 4, wherein R is an acetyl group or an alcohol-protecting group. The process involves reacting 3 with a triflating agent in the presence of a nicotinate (3-pyridinecarboxylate) of a C1-C4 alcohol, preferably methyl nicotinate (methyl 3-pyridinecarboxylate) or ethyl nicotinate (ethyl 3-pyridinecarboxylate), to give 4. The method can be conveniently used in a process for the preparation of Abiraterone or Abiraterone acetate.
    Type: Application
    Filed: May 15, 2015
    Publication date: November 26, 2015
    Inventors: Marco Alpegiani, Tania Cristiano
  • Process for the synthesis of beta-lactam derivatives
    Patent number: 6642378
    Abstract: The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C1-C4 alkyl ester is used as a solvent for the carbamoylation reaction.
    Type: Grant
    Filed: March 13, 2002
    Date of Patent: November 4, 2003
    Assignee: Antibioticos S.p.A.
    Inventors: Walter Cabri, Enrico Siviero, Paola Luigia Daverio, Tania Cristiano, Claudio Felisi, Davide Longoni