Patents by Inventor Tania Gendron

Tania Gendron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MATERIALS FOR TREATING TDP-43 PROTEINOPATHIES
    Publication number: 20240115736
    Abstract: Methods and materials for treating a mammal having a TDP-43 proteinopathy (a disorder characterized by the accumulation and/or aggregation of TDP-43 polypeptides in the central nervous system) are provided herein. For example, this document provides methods and materials for administering nucleic acids encoding polyadenylate-binding protein 4 (PABPC4) to a mammal having a TDP-43 proteinopathy, such that the level of PABPC4 in the central nervous system of the mammal is increased.
    Type: Application
    Filed: February 11, 2022
    Publication date: April 11, 2024
    Inventors: Tania Gendron, Marka Van Blitterswijk
  • METHODS AND MATERIALS FOR DETECTING C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION POSITIVE FRONTOTEMPORAL LOBAR DEGENERATION OR C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION POSITIVE AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20170059586
    Abstract: This document provides methods and materials for detecting C9ORF72 hexanucleotide (GGGGCC) (SEQ ID NO: 3) repeat expansion positive (C9+) frontotemporal lobar degeneration or C9+ amyotrophic lateral sclerosis. For example, methods and materials related to using anti-(GP)8 (SEQ ID NO: 2) antibodies to identify mammals (e.g., humans) having C9+ FTLD or C9+ ALS are provided.
    Type: Application
    Filed: August 24, 2016
    Publication date: March 2, 2017
    Inventors: Leonard Petrucelli, Peter E. Ash, Tania Gendron
  • Methods and materials for detecting C9ORF72 hexanucleotide repeat expansion positive frontotemporal lobar degeneration or C9ORF72 hexanucleotide repeat expansion positive amyotrophic lateral sclerosis
    Patent number: 9448232
    Abstract: This document provides methods and materials for detecting C9ORF72 hexanucleotide (GGGGCC) (SEQ ID NO: 3) repeat expansion positive (C9+) frontotemporal lobar degeneration or C9+ amyotrophic lateral sclerosis. For example, methods and materials related to using anti-(GP)8 (SEQ ID NO: 2) antibodies to identify mammals (e.g., humans) having C9+ FTLD or C9+ ALS are provided.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: September 20, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Leonard Petrucelli, Peter E. Ash, Tania Gendron
  • METHODS AND MATERIALS FOR DETECTING C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION POSITIVE FRONTOTEMPORAL LOBAR DEGENERATION OR C9ORF72 HEXANUCLEOTIDE REPEAT EXPANSION POSITIVE AMYOTROPHIC LATERAL SCLEROSIS
    Publication number: 20140206102
    Abstract: This document provides methods and materials for detecting C9ORF72 hexanucleotide (GGGGCC) (SEQ ID NO: 3) repeat expansion positive (C9+) frontotemporal lobar degeneration or C9+ amyotrophic lateral sclerosis. For example, methods and materials related to using anti-(GP)8 (SEQ ID NO: 2) antibodies to identify mammals (e.g., humans) having C9+ FTLD or C9+ ALS are provided.
    Type: Application
    Filed: January 23, 2014
    Publication date: July 24, 2014
    Inventors: Leonard Petrucelli, Peter E. Ash, Tania Gendron
  • DIAGNOSING NEURODEGENERATIVE DISEASES
    Publication number: 20100136573
    Abstract: This document provides methods and materials related to determining whether or not a mammal (e.g., a human) has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or amyotrophic lateral sclerosis (ALS)). For example, methods and materials for using the levels of TDP-43 polypeptides and/or TDP-43 polypeptide cleavage products (e.g., 25 kD and 35 kD TDP-43 polypeptide cleavage products) in a biological fluid (e.g., cerebrospinal fluid) to determine whether or not a mammal has a neurodegenerative disease (e.g., frontotemporal dementia, AD, or ALS) are provided.
    Type: Application
    Filed: November 30, 2009
    Publication date: June 3, 2010
    Inventors: Leonard Petrucelli, Yongjie Zhang, Yafei Xu, Tania Gendron