Patents by Inventor Tania GUARDADO ALVAREZ

Tania GUARDADO ALVAREZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photo-Cleavable Surfactants
    Publication number: 20230139837
    Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-translational modifications.
    Type: Application
    Filed: December 20, 2022
    Publication date: May 4, 2023
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ying GE, Song JIN, Tania GUARDADO ALVAREZ, Kyle BROWN
  • Photo-cleavable surfactants
    Patent number: 11567085
    Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-translational modifications.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: January 31, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ying Ge, Song Jin, Tania Guardado Alvarez, Kyle Brown
  • Photo-Cleavable Surfactants
    Publication number: 20210253519
    Abstract: The present invention provides photo-cleavable anionic surfactants, particularly 4-hexylphenylazosulfonate (Azo) and sodium 4-hexylphenylazosulfonate derivatives, which can be rapidly degraded upon UV irradiation, for top-down and bottom-up proteomics. These surfactants can effectively solubilize proteins and peptide fragments with performance comparable to sodium dodecyl sulfate (SDS) and are compatible with mass spectrometry analysis of the solubilized proteins and peptide fragments. Top-down proteomic studies using the present photo-cleavable anionic surfactants has allowed the detection of 100-fold more unique proteoforms as compared to controls and has enabled the solubilization of membrane proteins for comprehensive characterization of protein post-trans-modifications.
    Type: Application
    Filed: June 4, 2019
    Publication date: August 19, 2021
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ying GE, Song JIN, Tania GUARDADO ALVAREZ, Kyle BROWN