Patents by Inventor Tania Vu
Tania Vu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230260116Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: ApplicationFiled: April 26, 2023Publication date: August 17, 2023Inventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
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Patent number: 11663717Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: GrantFiled: May 25, 2021Date of Patent: May 30, 2023Assignees: Ventana Medical Systems, Inc., OREGON HEALTH & SCIENCE UNIVERSITYInventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
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Publication number: 20210279870Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: ApplicationFiled: May 25, 2021Publication date: September 9, 2021Inventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
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Patent number: 11049247Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: GrantFiled: March 6, 2020Date of Patent: June 29, 2021Assignees: Ventana Medical Systems, Inc., OREGON HEALTH & SCIENCE UNIVERSITYInventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
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Publication number: 20200219256Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: ApplicationFiled: March 6, 2020Publication date: July 9, 2020Inventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tothu Tania Vu, Brian J. Druker, Thomas Jacob
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Patent number: 10664967Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: GrantFiled: May 26, 2017Date of Patent: May 26, 2020Assignees: VENTANA MEDICAL SYSTEMS, INC., OREGON HELATH & SCIENCE UNIVERSITYInventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tania Vu, Brian J. Druker, Thomas Jacob
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Publication number: 20200081012Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.Type: ApplicationFiled: September 16, 2019Publication date: March 12, 2020Inventors: Tania Vu, Thomas Jacob, Brian J. Druker
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Patent number: 10473667Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.Type: GrantFiled: June 7, 2016Date of Patent: November 12, 2019Assignee: Oregon Health & Science UniversityInventors: Tania Vu, Thomas Jacob, Brian J Druker
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Patent number: 10083341Abstract: Methods and systems for quantifying cellular activity using labeled probes, e.g., quantum dots, are disclosed. In one example approach, a method for quantifying cellular activity in a sample containing intact cells having labeled complexes comprises receiving images of the sample at a plurality of depths and detecting individual intact cells in the images of the sample at the plurality of depths. For each detected cell, discrete labels may be detected and localized in the cell at each depth, a total number of detected and localized labels may be calculated in the cell, and an activity level of the target molecule for the labeled probe in the cell determined.Type: GrantFiled: November 19, 2015Date of Patent: September 25, 2018Assignee: Oregon Health & Science UniversityInventors: Tania Vu, Thomas Jacob
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Publication number: 20170262984Abstract: Methods, systems, and apparatuses for detecting and describing heterogeneity in a cell sample are disclosed herein. A plurality of fields of view (FOV) are generated for one or more areas of interest (AOI) within an image of the cell sample are generated. Hyperspectral or multispectral data from each FOV is organized into an image stack containing one or more z-layers, with each z-layer containing intensity data for a single marker at each pixel in the FOV. A cluster analysis is applied to the image stacks, wherein the clustering algorithm groups pixels having a similar ratio of detectable marker intensity across layers of the z-axis, thereby generating a plurality of clusters having similar expression patterns.Type: ApplicationFiled: May 26, 2017Publication date: September 14, 2017Inventors: Michael Barnes, David Chafin, Karl Garsha, Thomas M. Grogan, Esteban Roberts, Benjamin Stevens, Franklin Ventura, Christophe Chefd'hotel, Kandavel Shanmugam, Joe Gray, Damien Ramunno-Johnson, Tania Vu
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Publication number: 20160377627Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.Type: ApplicationFiled: June 7, 2016Publication date: December 29, 2016Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Tania Vu, Thomas Jacob
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Publication number: 20160140382Abstract: Methods and systems for quantifying cellular activity using labeled probes, e.g., quantum dots, are disclosed. In one example approach, a method for quantifying cellular activity in a sample containing intact cells having labeled complexes comprises receiving images of the sample at a plurality of depths and detecting individual intact cells in the images of the sample at the plurality of depths. For each detected cell, discrete labels may be detected and localized in the cell at each depth, a total number of detected and localized labels may be calculated in the cell, and an activity level of the target molecule for the labeled probe in the cell determined.Type: ApplicationFiled: November 19, 2015Publication date: May 19, 2016Applicant: OREGON HEALTH & SCIENCE UNIVERSITYInventors: Tania Vu, Thomas Jacob
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Publication number: 20140212890Abstract: Embodiments herein provide methods, apparatuses, and systems for detecting, monitoring, measuring, and/or characterizing the activity of phosphoproteins, such as tyrosine kinases (TKs) and downstream proteins in TK signal transduction pathways (e.g., TK pathway proteins). In various embodiments, the methods, apparatuses, and systems may use nanoparticles, such as quantum dots (QD), to detect and/or characterize the abnormally overactive TK signaling pathways that underlie tumorgenesis and tumor progression. In various embodiments, the QD-based methods, apparatuses, and systems may have a sufficiently high degree of sensitivity to enable the identification of new TK signaling pathway markers, for example for use in diagnosing, staging, monitoring, and/or prognosing cancers, or in evaluating the efficacy of cancer therapeutics.Type: ApplicationFiled: September 6, 2013Publication date: July 31, 2014Applicant: Oregon Health & Science UniversityInventors: Thomas Jacob, Tania Vu