Patents by Inventor Tanja Kveder

Tanja Kveder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorometric immunoassay for detection of anti-dsDNA antibodies
    Patent number: 10191048
    Abstract: The present invention relates to the field of immunological methods, more precisely to the field of detection methods for antibodies against double-stranded DNA (dsDNA) for diagnostics of chronic autoimmune diseases, such as systemic lupus erythematosus (SLE). The fluorometric immunoassay method for detection of anti-dsDNA solves the technical problem of designing a method for detection of the aforesaid antibodies, which would be faster, cheaper and less toxic as the standard Farr-RIA method, but would have the same diagnostic specificity (which is 100%) and improved diagnostic sensitivity (for 3%). Detection of anti-dsDNA is based on detection of fluorescence in two fractions of samples, in the supernatant and in the sample with a precipitate, which contains immune complexes composed of added dsDNA and anti-dsDNA present in the patient's serum, wherein the detected fluorescence is a consequence of binding fluorescent dyes with dsDNA bound in the complexes or with free dsDNA.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: January 29, 2019
    Inventors: Tanja Kveder, Katja Lakota, Tinka Svec, Sasa Cucnik, Polona Zigon, Ales Ambrozic, Snezna Sodin-Semrl, Borut Bozic, Matija Tomsic
  • FLUOROMETRIC IMMUNOASSAY FOR DETECTION OF ANTI-DSDNA ANTIBODIES
    Publication number: 20160349255
    Abstract: The present invention relates to the field of immunological methods, more precisely to the field of detection methods for antibodies against double-stranded DNA (dsDNA) for diagnostics of chronic autoimmune diseases, such as systemic lupus erythematosus (SLE). The fluorometric immunoassay method for detection of anti-dsDNA solves the technical problem of designing a method for detection of the aforesaid antibodies, which would be faster, cheaper and less toxic as the standard Farr-RIA method, but would have the same diagnostic specificity (which is 100%) and improved diagnostic sensitivity (for 3%). Detection of anti-dsDNA is based on detection of fluorescence in two fractions of samples, in the supernatant and in the sample with a precipitate, which contains immune complexes composed of added dsDNA and anti-dsDNA present in the patient's serum, wherein the detected fluorescence is a consequence of binding fluorescent dyes with dsDNA bound in the complexes or with free dsDNA.
    Type: Application
    Filed: February 3, 2015
    Publication date: December 1, 2016
    Applicant: UNIVERZITETNI KLINICNI CENTER LJUBLJANA
    Inventors: Tanja Kveder, Katja Lakota, Tinka Svec, Sasa Cucnik, Polona Zigon, Ales Ambrozic, Snezna Sodin-Semrl, Borut Bozic, Matija Tomsic