Patents by Inventor Tanner Monroe

Tanner Monroe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dominant active yap, a hippo effector, induces chromatin accessibility and cardiomyocyte renewal
    Patent number: 12138284
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Grant
    Filed: September 12, 2022
    Date of Patent: November 12, 2024
    Assignee: BAYLOR COLLEGE OF MEDICINE
    Inventors: Tanner Monroe, John Leach, James F. Martin
  • DOMINANT ACTIVE YAP, A HIPPO EFFECTOR, INDUCES CHROMATIN ACCESSIBILITY AND CARDIOMYOCYTE RENEWAL
    Publication number: 20230063735
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Application
    Filed: September 12, 2022
    Publication date: March 2, 2023
    Inventors: Tanner Monroe, John Leach, James F. Martin
  • Dominant active yap, a hippo effector, induces chromatin accessibility and cardiomyocyte renewal
    Patent number: 11484553
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: November 1, 2022
    Assignee: Baylor College of Medicine
    Inventors: Tanner Monroe, John Leach, James F. Martin
  • DOMINANT ACTIVE YAP, A HIPPO EFFECTOR, INDUCES CHROMATIN ACCESSIBILITY AND CARDIOMYOCYTE RENEWAL
    Publication number: 20200016212
    Abstract: The present disclosure encompasses methods for generating cells or tissue from existing cells with one or more mutated variants of Yap. In specific embodiments, the disclosure regards treatment of existing cardiomyocytes with one or more mutated variants of Yap that causes them to divide and generate new cardiomyocytes. In specific cases, the mutated variant of Yap has serine-to-alanine substitutions at 1, 2, 3, 4, 5, 6, or more serines of Yap.
    Type: Application
    Filed: March 14, 2018
    Publication date: January 16, 2020
    Inventors: Tanner Monroe, John Leach, James F. Martin