Patents by Inventor Tanya Bhatia

Tanya Bhatia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Type II restriction endonuclease, CstMI, obtainable from M82B and a process for producing the same
    Patent number: 7186538
    Abstract: In accordance with the present invention, there is provided a novel type II restriction endonuclease, obtainable from Corynebacterium striatum M82B, hereinafter referred to as “CstMI”, which endonuclease: (1) recognizes the nucleotide sequence 5?-AAGGAG-3? in a double-stranded DNA molecule as shown below, 5?-AAGGAGN20?-3? 3?-TTCCTCN18?-5? (wherein G represents guanine, C represents cytosine, A represents adenine, T represents thymine and N represents either G, C, A, or T); (2) cleaves said sequence at the phosphodiester bonds between the 20th and the 21th nucleotides 3? to the recognition sequence in the 5?-AAGGAG-3 strand of the DNA, and between the 18th and 19th nucleotides 5? to the recognition sequence in the complement stand, 5?-CTCCTT-3?, to produce a 2 base 3?extension; and (3) possesses a second enzymatic activity that recognizes the same DNA sequence, 5?-AAGGAG-3?, but modifies this sequence by the addition of a methyl group to prevent cleavage by the CstMI endon
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: March 6, 2007
    Assignee: New England Biolabs, Inc.
    Inventors: Richard D. Morgan, Tanya Bhatia
  • Recombinant type II restriction endonucleases, MmeI and related endonucleases and methods for producing the same
    Patent number: 7115407
    Abstract: In accordance with the present invention, there is provided a DNA (deoxyribonucleic acid) fragment which encodes the MmeI type II restriction endonuclease enzyme. This one polypeptide possesses two related enzymatic functions; namely an endonuclease activity which recognizes the DNA sequence 5?-TCC(Pu)AC-3? and cleaves as indicated by the arrows: 5?-TCCRAC(N20)?-3? 3?-AGGYTG(N18)?-5? and a second enzymatic activity that recognizes the same DNA sequence, 5?-TCC(Pu)AC-3?, but modifies this sequence by the addition of a methyl group to prevent cleavage by the MmeI endonuclease activity.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: October 3, 2006
    Assignee: New England BioLabs, Inc.
    Inventors: Richard D. Morgan, Tanya Bhatia, Theodore Davis, Lindsay Lovasco
  • Novel type II restriction endonuclease, CstMI, obtainable from corynebacterium striatum M82B and a process for producing the same
    Publication number: 20050009034
    Abstract: In accordance with the present invention, there is provided a novel type II restriction endonuclease, obtainable from Corynebacterium striatum M82B, hereinafter referred to as “CstMI”, which endonuclease: (1) recognizes the nucleotide sequence 5?-AAGGAG-3? in a double-stranded DNA molecule as shown below, 5?-AAGGAGN20?-3? 3?-TTCCTCN18?-5? (wherein G represents guanine, C represents cytosine, A represents adenine, T represents thymine and N represents either G, C, A, or T); (2) cleaves said sequence at the phosphodiester bonds between the 20th and the 21th nucleotides 3? to the recognition sequence in the 5?-AAGGAG-3 strand of the DNA, and between the 18th and 19th nucleotides 5? to the recognition sequence in the complement stand, 5?-CTCCTT-3?, to produce a 2 base 3?extension; and (3) possesses a second enzymatic activity that recognizes the same DNA sequence, 5?-AAGGAG-3?, but modifies this sequence by the addition of a methyl group to prevent cleavage by the CstMI endonuclease ac
    Type: Application
    Filed: July 10, 2003
    Publication date: January 13, 2005
    Inventors: Richard Morgan, Tanya Bhatia
  • Recombinant type II restriction endonucleases, MmeI and related endonucleases and methods for producing the same
    Publication number: 20040091911
    Abstract: In accordance with the present invention, there is provided a DNA (deoxyribonucleic acid) fragment which encodes the MmeI type II restriction endonuclease enzyme.
    Type: Application
    Filed: July 10, 2003
    Publication date: May 13, 2004
    Inventors: Richard D. Morgan, Tanya Bhatia, Theodore Davis, Lindsay Lovasco